Microdosing Clinical Study: Pharmacokinetic, Pharmacogenomic (SLCO2B1), and Interaction (Grapefruit Juice) Profiles of Celiprolol Following the Oral Microdose and Therapeutic Dose

2012 ◽  
Vol 52 (7) ◽  
pp. 1078-1089 ◽  
Author(s):  
Ichiro Ieiri ◽  
Yohei Doi ◽  
Kazuya Maeda ◽  
Tomohiro Sasaki ◽  
Miyuki Kimura ◽  
...  
Author(s):  
A. V. Sorokina ◽  
S. V. Alekseeva ◽  
I. A. Miroshkina ◽  
K. S. Kachalov ◽  
A. D. Zaharov ◽  
...  

Presents results of a study of subchronic toxicity of homeopathic drug Dantinorm Baby in finished dosage form. The drug in the form of a ready solution was administered daily orally for one month to outbred rats Infanta and chinchilla rabbits at a dose of 0.3 ml/kg, corresponding to the therapeutic, and 3 ml/kg, exceeding the therapeutic dose 10 times. Clinical, laboratory and histopathological studies performed in accordance with the General Protocol, showed no toxic effects of homeopathic preparation of Dantinorm Baby. The totality of the obtained data of the subchronic experiment indicates that there are no obstacles to the clinical study of the drug Dantinorm Baby in the range of therapeutic dosages.


2017 ◽  
Vol 106 (9) ◽  
pp. 2688-2694 ◽  
Author(s):  
Yushi Kashihara ◽  
Ichiro Ieiri ◽  
Takashi Yoshikado ◽  
Kazuya Maeda ◽  
Masato Fukae ◽  
...  

1981 ◽  
Vol 12 (1) ◽  
pp. 26-35 ◽  
Author(s):  
Donald L. McCanna ◽  
Giacinto DeLapa

This report reviews 27 cases of children exhibiting functional hearing loss. The study reveals that most students were in the upper elementary grades and were predominantly females. These subjects were functioning below their ability level in school and were usually in conflict with school, home, or peers. Tests used were selected on the basis of their helping to provide early identification. The subjects' oral and behavioral responses are presented, as well as ways of resolving the hearing problem. Some helpful counseling techniques are also presented.


1951 ◽  
Vol 17 (1) ◽  
pp. 35-38 ◽  
Author(s):  
Frank C. Bone ◽  
Chester Cassel ◽  
Julian M. Ruffin ◽  
Robert J. Reeves

1961 ◽  
Vol 40 (2) ◽  
pp. 188-196 ◽  
Author(s):  
Charles H. Brown ◽  
Mauro Merlo ◽  
John B. Hazard

2007 ◽  
Vol 177 (4S) ◽  
pp. 197-197 ◽  
Author(s):  
Hazem O. Orabi ◽  
Tamer A. Aboushwareb ◽  
Yuan Yuan Zhang ◽  
James J. Yoo ◽  
Anthony Atala

2005 ◽  
Vol 29 (3) ◽  
pp. 291-302 ◽  
Author(s):  
P. Sewell ◽  
J. Vinney ◽  
S. Noroozi ◽  
R. Amali ◽  
S. Andrews

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