scholarly journals Study the subchronic toxicity of the drug Dantinorm Baby

2021 ◽  
pp. 52-60
Author(s):  
A. V. Sorokina ◽  
S. V. Alekseeva ◽  
I. A. Miroshkina ◽  
K. S. Kachalov ◽  
A. D. Zaharov ◽  
...  
Keyword(s):  
Clinical Study ◽  
Therapeutic Dose ◽  
Dosage Form ◽  
Clinical Laboratory ◽  
Toxic Effects ◽  
Subchronic Toxicity ◽  
Homeopathic Drug ◽  
Homeopathic Preparation ◽  
Histopathological Studies

Presents results of a study of subchronic toxicity of homeopathic drug Dantinorm Baby in finished dosage form. The drug in the form of a ready solution was administered daily orally for one month to outbred rats Infanta and chinchilla rabbits at a dose of 0.3 ml/kg, corresponding to the therapeutic, and 3 ml/kg, exceeding the therapeutic dose 10 times. Clinical, laboratory and histopathological studies performed in accordance with the General Protocol, showed no toxic effects of homeopathic preparation of Dantinorm Baby. The totality of the obtained data of the subchronic experiment indicates that there are no obstacles to the clinical study of the drug Dantinorm Baby in the range of therapeutic dosages.

scholarly journals Study of chronic toxicity of the GB-115 drug formulation

2020 ◽  
pp. 37-44
Author(s):  
A. V. Sorokina ◽  
S. V. Alekseeva ◽  
I. A. Miroshkina ◽  
V. V. Zabrodina ◽  
L. G. Kolik ◽  
...  
Keyword(s):  
Therapeutic Dose ◽  
Chronic Toxicity ◽  
Clinical Laboratory ◽  
Drug Formulation ◽  
Toxic Effects ◽  
The Novel ◽  
Coagulation Activity ◽  
Solid Dosage

The results of the study of chronic toxicity of the drug formulation of anxiolytic GB-115 are presented. The novel dipeptide in the form of a tablet mass was administered daily orally for 6 months to outbred rats and rabbits of the chinchilla breed at a dose of 1 mg/kg corresponding to the therapeutic and 50 mg/kg exceeding the therapeutic dose by 50 times. Clinical, laboratory and pathohistological studies performed in accordance with the General Protocol demonstrated the absence of toxic effects of the GB-115 drug formulation. The exception was the reversible changes in the coagulation activity in rats and rabbits, which were not associated with the dose of the GB-115 solid dosage from.

scholarly journals THE TOTAL NON-PROTEIN NITROGEN OF THE BLOOD IN NEPHRITIS AND ALLIED CONDITIONS

1913 ◽  
Vol 18 (3) ◽  
pp. 228-241 ◽  
Author(s):  
Clifford B. Farr ◽  
J. Harold Austin
Keyword(s):  
Cardiovascular Disease ◽  
Clinical Study ◽  
Clinical Improvement ◽  
Clinical Laboratory ◽  
Nitrogen Retention ◽  
Renal Lesion ◽  
Normal Range ◽  
Protein Nitrogen ◽  
Chronic Nephritis

1. In a series of non-nephritic individuals the total non-protein nitrogen of the blood, determined by Folin's method, was found to lie between 15 and 43 milligrams per 100 cubic centimeters. From 50 to 60 per cent. of this was in the ammonia-urea fraction. 2. In cardiovascular disease with renal congestion, but without other renal lesion, there was no evidence of increase of non-protein nitrogen in the blood, nor of alteration of the ammonia-urea percentage. 3. In chronic nephritis with marked albuminuria and edema there was very little, if any, increase or alteration. 4. In chronic nephritis with hypertension the non-protein nitrogen was definitely increased, ranging from 40 to 180 milligrams per 100 cubic centimeters of blood. The percentage of the ammonia-urea fraction was usually higher than in non-nephritic cases. 5. Cases showing high non-protein nitrogen values were subject to rapid fluctuations in these values in the course of a few days. As a rule, clinical improvement was associated with a fall of the non-protein nitrogen figures to nearer the normal range. 6. Uremia was almost always accompanied by an increase of non-protein nitrogen in the blood, but no constant relation could be established between the degree of increase and the tendency to uremia. 7. Our cases have not yet been followed for a long enough period to admit of conclusions as to the possible relation between the degree of non-protein nitrogen retention and ultimate prognosis. 8. We believe this method to be a valuable aid in the clinical study of nephritis and that it can be readily carried out in any well equipped clinical laboratory.

scholarly journals Ultrasound with laparoscopy for the diagnosis of abdominal disorders in cattle

2021 ◽  
Vol 41 ◽  
Author(s):  
José Ricardo B. Silva ◽  
José Augusto B. Afonso ◽  
Carla L. Mendonça ◽  
Jobson Filipe P. Cajueiro ◽  
Juliana M. Alonso ◽  
...  
Keyword(s):  
Clinical Study ◽  
Clinical Laboratory ◽  
Abdominal Ultrasound ◽  
Accurate Diagnosis ◽  
Prospective Clinical Study ◽  
Focal Lesions ◽  
Diagnosis And Prognosis ◽  
Complete Blood Counts ◽  
The Right ◽  
Exploratory Laparoscopy

ABSTRACT: This study aimed to evaluate laparoscopy with abdominal ultrasound exams to establish accurate diagnosis and prognosis. The experimental design was a prospective clinical study. Nine adult crossbred bovines suffering from abdominal disorders were admitted to the cattle clinic for clinical examinations. Abdominal ultrasound was carried out, and complete blood counts were performed. Subsequently, exploratory laparoscopy was performed. After surgery (exploratory laparoscopy on the right or left side), animals with a severe prognosis or untreatable clinical condition were euthanised and necropsied. During laparoscopy, circumscribed reticuloperitonitis could not be detected, nor could other abnormalities in the cranioventral region of the abdomen previously observed on ultrasound and confirmed during necropsy. However, alterations due to peritoneal damage, such as adhesions, were observed dorsally in addition to alterations in macroscopic aspects of the peritoneal fluid. Exploratory standing laparoscopy through the paralumbar fossae may constitute a supplementary procedure for diagnosing abdominal disorders in cattle, but it is not suitable in cases of diseases characterised by focal lesions concentrated in the cranioventral region of the abdomen. When associated with clinical, laboratory, and ultrasound examinations, this technique may improve the accurate diagnosis and prognosis of abdominal disorders in cattle.

scholarly journals A new mucoadhesive dosage form for the management of oral lichen planus: Formulation study and clinical study

2010 ◽  
Vol 76 (3) ◽  
pp. 437-442 ◽  
Author(s):  
Francesco Cilurzo ◽  
Chiara G.M. Gennari ◽  
Francesca Selmin ◽  
Joel B. Epstein ◽  
Giovanni M. Gaeta ◽  
...  
Keyword(s):  
Clinical Study ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Dosage Form ◽  
Oral Lichen

scholarly journals Acute and subchronic toxicity studies of the original drug FS-1

2016 ◽  
Vol 85 (1) ◽  
pp. 9-16 ◽  
Author(s):  
Assem Kalykova ◽  
Tatyana Kustova ◽  
Zuriyadda Sakipova ◽  
Naiyla Ibragimova ◽  
Rinat Islamov ◽  
...  
Keyword(s):  
Alkaline Earth ◽  
Wide Spectrum ◽  
Recovery Period ◽  
Multidrug Resistant ◽  
Toxic Effects ◽  
Intragastric Administration ◽  
Subchronic Toxicity ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Iodine Complexes

Interest in iodine complexes has increased significantly in recent years because of their wide spectrum of biological activity. The FS-1 is an ion nanostructured complex formed by proteins and/or polypeptides, carbohydrates, salts of alkali and alkaline earth metals with intercalated iodine. Patented in 2014, it is intended for the treatment of infectious diseases of bacterial origin including nosocomial infections and multidrug resistant tuberculosis. The aim of the study was to determine its acute and subchronic toxicity. The study of acute and subchronic toxicity was performed on adult Wistar rats according to OECD guidelines. The data on acute toxicity showed LD50 > 2,000 mg/kg after a single intragastric administration. Twenty-eight days of FS-1 administration at a dose of 500 mg/kg resulted in toxic effects. At a dose of 250 mg/kg, the toxic effects were temporary and a return to normal followed after the recovery period. Doses of 100 mg/kg had no adverse effects on the rats.

scholarly journals A Clinical, Laboratory and Microbiological Evaluation on Efficacy of Dental Air Force Home Dental Cleaning System on Type 2 Diabetic and Nondiabetic Adult Chronic Periodontitis Patients: A 6-Month Clinical Study

2013 ◽  
Vol 2 (1) ◽  
pp. 1-8
Author(s):  
Ameet Madan Mani
Keyword(s):  
Clinical Study ◽  
Air Force ◽  
Chronic Periodontitis ◽  
Clinical Laboratory ◽  
Periodontal Diseases ◽  
Phase 1 ◽  
Cleaning System ◽  
Microbiological Parameters ◽  
Type 2 Diabetic

ABSTRACT Aim The study outlined to evaluate the clinical, laboratory and microbiological efficacy of Dental Air Force home dental cleaning system on type 2 diabetes and nondiabetic adult chronic periodontitis patients. Materials and methods A total of 100 adult chronic periodontitis subjects were recruited voluntary for this study. Clinical [plaque index (PI), gingival index (GI) and clinical attachment loss (CAL)], laboratory (C-reactive protein levels and glycated hemoglobin) and microbiological parameters were measured prior to phase 1 therapy; at 3rd and 6th month post phase 1 therapy. Comparative assessment was done among all the patients that were divided into four groups with Student paired t-test and analysis of variance (ANOVA). Results The results of this study showed that there was significant decrease in clinical, laboratory and microbiological parameters from baseline to 6 months in all the groups (i.e. p < 0.01). The subjects under groups using Dental Air Force home dental cleaning system showed highly significant reduction to all the parameters as compared to subjects under groups using toothbrush. Conclusion There was strong correlation between periodontal diseases and systemic parameters. Dental Air Force home dental cleaning system with the access to interdentally area helps in preventing the accumulation of dental plaque biofilm, thus able to maintain the clinical, laboratory and microbiological parameters at much lower levels as compared to traditional tooth brushing after phase I therapy. How to cite this article Mani S, Mani AM, Saini R. A Clinical, Laboratory and Microbiological Evaluation on Efficacy of Dental Air Force Home Dental Cleaning System on Type 2 Diabetic and Nondiabetic Adult Chronic Periodontitis Patients: A 6-Month Clinical Study. Int J Experiment Dent Sci 2013;2(1):1-8.

scholarly journals Acute and Subchronic Toxic Effects of the Fruits ofPhysalis peruvianaL.

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Basak Ozlem Perk ◽  
Sinem Ilgin ◽  
Ozlem Atli ◽  
Hale Gamze Duymus ◽  
Basar Sirmagul
Keyword(s):  
Fruit Juice ◽  
Troponin I ◽  
Troponin T ◽  
Qualitative Content Analysis ◽  
Toxic Effects ◽  
Control Group ◽  
Subchronic Toxicity ◽  
Male Group ◽  
Toxicity Studies

The fruit ofPhysalis peruvianaL. (PPL) has been traditionally used as antispasmodic, diuretic, antiseptic, sedative, and analgesic all over the world. We aimed to perform qualitative content analysis of the fruits of PPL and to clarify thein vitrogenotoxicity andin vivoacute and subchronic toxicity of the fruit. Lyophilized fruit juice does not induce genetic damage. In the acute toxicity studies, LD50 value of the fruit was found to be more than 5000 mg kg−1for both sexes. According to the subchronic toxicity studies, hepatic, renal, and hematological toxic effects were not induced in both sexes. Plasma troponin I (only in the group treated with 5000 mg kg−1of lyophilized fruit juice) and troponin T levels were significantly increased in male groups treated with lyophilized fruit juice compared to the control group. Furthermore, potassium level was significantly increased in the male group treated with 5000 mg kg−1of lyophilized fruit juice. These findings were considered to indicate the myocardial damage particularly in the male group treated with 5000 mg kg−1of lyophilized fruit juice. In conclusion, lyophilized fruit juice of PPL is shown to induce cardiac toxicity only at high doses and in male gender.

scholarly journals Experimental evaluation of toxic properties of LCTA-2034 by the oral routeof administration

2018 ◽  
Vol 17 (3) ◽  
pp. 81-88 ◽  
Author(s):  
M. I. Treschalin ◽  
I. D. Treschalin ◽  
V. A. Golibrodo ◽  
A. E. Shchekotikhin ◽  
E. R. Pereverzeva
Keyword(s):  
Body Weight ◽  
Therapeutic Dose ◽  
Clinical Laboratory ◽  
Hematological Parameters ◽  
Relative Weight ◽  
Oral Route ◽  
Post Treatment ◽  
Histological Evaluation ◽  
High Dose ◽  
Blood Biochemical

Introduction.New antitumor multitarget drug LCTA-2034, obtained in Gause Institute of New Antibiotics, has demonstrated high activity against prognostically significant transplantable mice tumors by the oral application.Objective.To investigate the toxicological properties of LCTA-2034 by the oral route of administration on rats.Materials and methods.Toxicological study of LCTA-2034 was performed on 30 male Wistar rats. Drug substance dissolved in potable water. 2 % solution was administrated per os at the 1 and 5 therapeutic dose (15 × 20 mg/kg or 15 × 100 mg/kg with 24-h interval). During the study dynamics of body weight, hematological parameters, blood biochemical parameters, electrocardiography and urinalysis were performed for all animals. Five animals in each group were sacrificed 1 and 30 days post treatment. The internal organs were subjected to histological evaluation.Results.The results of the study demonstrate that the treatment with low dose of LCTA-2034 does not produce any changes in majority of examined clinical-laboratory parameters with the exception of urinalysis revealed hematuria on day 1 post treatment. Microscopic pathology observation showed structure abnormalities of varying severity in liver, kidneys, heart, stomach, jejunum, ileum, spleen and thymus. Administration of high dose of LCTA-2034 caused mortality of 2 rats in group. The rest of the rats were observed a body weight lag, decrease of total leukocyte and erythrocyte count, hemoglobin and hematocrit level, relative weight of the thymus. Erythrocytes and nitrates were found in urine both on day 1 and on day 30 post treatment. In groups treated with high dose of the drug in addition to the listed above organs damage of the structure of lymph nodes, pancreas, ileum and brain was detected. Conclusion. Revealed toxic properties of LCTA-2034 depended on dose. Multiple administration of 1 therapeutic dose of the drug produces transient toxic effects completely reversible within 30 days. 

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