scholarly journals Spontaneous Neoplasm Incidences in Fischer 344 Rats and B6C3F1 Mice in Two-Year Carcinogenicity Studies: A National Toxicology Program Update

1998 ◽  
Vol 26 (3) ◽  
pp. 428-441 ◽  
Author(s):  
Joseph K. Haseman ◽  
James R. Hailey ◽  
Richard W. Morris
Keyword(s):  
Fischer 344 Rats ◽  
Fischer 344 ◽  
National Toxicology Program ◽  
B6c3f1 Mice ◽  
Spontaneous Neoplasm

Two-Year Toxicity and Carcinogenicity Studies of Panax ginseng in Fischer 344 Rats and B6C3F1 Mice

2011 ◽  
Vol 39 (04) ◽  
pp. 779-788 ◽  
Author(s):  
Po-Chuen Chan ◽  
John C. Peckham ◽  
David E. Malarkey ◽  
Grace E. Kissling ◽  
Gregory S. Travlos ◽  
...  
Keyword(s):  
Panax Ginseng ◽  
National Institutes Of Health ◽  
Fischer 344 Rats ◽  
Herbal Supplements ◽  
Experimental Conditions ◽  
Fischer 344 ◽  
National Toxicology Program ◽  
Carcinogenic Potential ◽  
The Us ◽  
B6c3f1 Mice

Ginseng is one of the most popular herbal supplements on the US market. Numerous reports of adverse effects from products containing ginseng have been filed with the US Food and Drug Administration (FDA) and the literature documents a "ginseng abuse syndrome" among regular users. However, the chronic toxic effects of ginseng are not well characterized. Because of its significant human exposure and the fact that little information on its toxicity is available, Panax ginseng was nominated by the US National Institutes of Health (NIH) to the US National Toxicology Program (NTP) to assess its carcinogenic potential. In this paper, we reported the results of NTP chronic toxicity and tumorigenicity bioassay. It shows that, under these experimental conditions, Panax ginseng is not toxic or tumorigenic.

DNA adduct formation in B6C3F1 mice and Fischer-344 rats exposed to 1, 2, 3-trichloropropane

1995 ◽  
Vol 16 (6) ◽  
pp. 1419-1474 ◽  
Author(s):  
David K. La ◽  
Patrick D. Lilly ◽  
Robert J. Anderegg ◽  
James A. Swenberg
Keyword(s):  
Adduct Formation ◽  
Dna Adduct ◽  
Fischer 344 Rats ◽  
Fischer 344 ◽  
B6c3f1 Mice

scholarly journals Oncogenicity Testing of 2-Ethylhexanol in Fischer 344 Rats and B6C3F1 Mice

1996 ◽  
Vol 31 (1) ◽  
pp. 29-41
Author(s):  
B. D. ASTILL ◽  
R. GINGELL ◽  
D. GUEST ◽  
J. HELLWIG ◽  
J. R. HODGSON ◽  
...  
Keyword(s):  
Fischer 344 Rats ◽  
Fischer 344 ◽  
B6c3f1 Mice

Monochlorodiisobutylene Vapor: Acute and 9-Day Inhalation Studies in Fischer-344 Rats and B6C3F1 Mice

1985 ◽  
Vol 5 (3) ◽  
pp. 506-514
Author(s):  
WILLIAM M. SNELLINGS ◽  
DAROL E. DODD ◽  
HAROLD C. GRICE ◽  
RICHARD D. PHILLIPS
Keyword(s):  
Fischer 344 Rats ◽  
Fischer 344 ◽  
B6c3f1 Mice
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