Respiratory tract toxicity of inhaled hydrogen sulfide in Fischer-344 rats, Sprague–Dawley rats, and B6C3F1 mice following subchronic (90-day) exposure

2004 ◽  
Vol 198 (1) ◽  
pp. 29-39 ◽  
Author(s):  
David C Dorman ◽  
Melanie F Struve ◽  
Elizabeth A Gross ◽  
Karrie A Brenneman
Keyword(s):  
Hydrogen Sulfide ◽  
Respiratory Tract ◽  
Fischer 344 Rats ◽  
Sprague Dawley ◽  
Fischer 344 ◽  
Sprague Dawley Rats ◽  
B6c3f1 Mice

Glucose-induced insulin secretion by perfused pancreas of 2- and 12-mo-old Fischer 344 rats

1984 ◽  
Vol 247 (3) ◽  
pp. E385-E388
Author(s):  
D. L. Curry ◽  
G. Reaven ◽  
E. Reaven
Keyword(s):  
Insulin Secretion ◽  
Islet Cell ◽  
Cell Mass ◽  
Fischer 344 Rats ◽  
Sprague Dawley ◽  
Fischer 344 ◽  
Sprague Dawley Rats ◽  
Glucose Challenge ◽  
Species Specific ◽  
Beta Cell Response

Previous studies have shown that cells from older Sprague-Dawley rats secrete insulin less efficiently in response to a maximal glucose challenge than do beta-cells from young animals. In the current study we have asked whether this change in beta-cell response occurs in another strain of rat, and, if so, whether the secretory defect occurs at submaximal as well as maximal glucose stimulatory levels. Pancreas perfusions were carried out on 2- and 12-mo-old Fischer 344 rats at perfusate glucose concentrations of 150 and 300 mg/dl. The secretory data for each pancreas was subsequently corrected for differences in islet cell mass and expressed as insulin secretion per unit islet cell. The results show that 12-mo-old Fischer rats release more insulin per total pancreas than do 2-mo-old animals at both glucose concentrations. However when corrected for islet cell mass, the amount of insulin secretion per islet cell is actually reduced in the older Fischer rat. These data are comparable to those seen previously in the 12-mo-old Sprague-Dawley rat and indicate that the insulin secretory defect seen as rats grow older is not species specific.

scholarly journals Assessment of immunotoxicity in female Fischer 344/N and Sprague Dawley rats and female B6C3F1 mice exposed to hexavalent chromium via the drinking water

2017 ◽  
Vol 14 (1) ◽  
pp. 215-227 ◽  
Author(s):  
Kelly A. Shipkowski ◽  
Christopher M. Sheth ◽  
Matthew J. Smith ◽  
Michelle J. Hooth ◽  
Kimber L. White ◽  
...  
Keyword(s):  
Drinking Water ◽  
Hexavalent Chromium ◽  
Sprague Dawley ◽  
Fischer 344 ◽  
Sprague Dawley Rats ◽  
B6c3f1 Mice

Comparison of the disposition of butadiene epoxides in Sprague–Dawley rats and B6C3F1 mice following a single and repeated exposures to 1,3-butadiene via inhalation

Toxicology ◽  
1997 ◽  
Vol 123 (1-2) ◽  
pp. 125-134 ◽  
Author(s):  
Janice R Thornton-Manning ◽  
Alan R Dahl ◽  
William E Bechtold ◽  
William C Griffith Jr. ◽  
Rogene F Henderson
Keyword(s):  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
B6c3f1 Mice
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