Extranodal Head and Neck Sinus Histiocytosis with Massive Lymphadenopathy

SummarySinus histiocytosis with massive lymphadenopathy is a rare, benign lympho-proliferative disorder of unknown aetiology that chiefly affects the cervical lymphnodes of children. Various extranodal manifestations are recognized, especially in the head and neck. A case is described in a Nigerian child that illustrates problems of differential diagnosis.

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Extra nodal Rosai Dorfman disease of nasal septal mucosa without lymphadenopathy

Journal of Pathology of Nepal ◽

10.3126/jpn.v6i11.15685 ◽

2016 ◽

Vol 6 (11) ◽

pp. 968-970

Author(s):

P Raje ◽

P Vyas

Keyword(s):

Lymph Nodes ◽

Head And Neck ◽

Nasal Septum ◽

Sinus Histiocytosis ◽

Extranodal Involvement ◽

Massive Lymphadenopathy ◽

Rosai Dorfman Disease ◽

Systemic Symptoms

Rosai–Dorman disease, also known as sinus histiocytosis with massive lymphadenopathy, typically presents as massive enlargement of lymph nodes accompanied by systemic symptoms. Extranodal involvement is also known usually in head and neck regions. Rarely the disease presents at extranodal sites only without involvement of lymph nodes.We present a case of 58 years-old female who presented with mass in nasal septum without involvement of lymph nodes. The mass was removed surgically and diagnosis was made on histological grounds with classical indings of histiocytic proliferation and emperipolesis.

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Sinus Histiocytosis with Massive Lymphadenopathy (Rosai-Dorfman Disease): Imaging Manifestations in the Head and Neck

American Journal of Roentgenology ◽

10.2214/ajr.08.1114 ◽

2008 ◽

Vol 191 (6) ◽

pp. W299-W306 ◽

Cited By ~ 65

Author(s):

Donald V. La Barge ◽

Karen L. Salzman ◽

H. Ric Harnsberger ◽

Lawrence E. Ginsberg ◽

Bronwyn E. Hamilton ◽

...

Keyword(s):

Head And Neck ◽

Sinus Histiocytosis ◽

Massive Lymphadenopathy ◽

Rosai Dorfman Disease

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Head and Neck Sinus Histiocytosis with Massive Lymphadenopathy Radiology–Pathology Correlation

Head and Neck Pathology ◽

10.1007/s12105-018-0941-3 ◽

2018 ◽

Vol 13 (4) ◽

pp. 656-660 ◽

Cited By ~ 2

Author(s):

Vincent Cracolici ◽

Sandeep Gurbuxani ◽

Daniel T. Ginat

Keyword(s):

Head And Neck ◽

Sinus Histiocytosis ◽

Massive Lymphadenopathy

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Sinus Histiocytosis with Massive Lymphadenopathy

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348948909800316 ◽

1989 ◽

Vol 98 (3) ◽

pp. 241-242 ◽

Cited By ~ 4

Author(s):

Nour Sneige ◽

John G. Batsakis

Keyword(s):

Nasal Cavity ◽

Head And Neck ◽

Salivary Glands ◽

Clinical Course ◽

Clinical Manifestations ◽

Cervical Lymphadenopathy ◽

Sinus Histiocytosis ◽

Massive Lymphadenopathy

Sinus histiocytosis with massive lymphadenopathy is a lymphoreticular disorder of obscure pathogenesis with extranodal lesions and a variable clinical course. Clinical manifestations are most often in the head and neck, with 97% of patients showing cervical lymphadenopathy and a significant but lesser number having lesional infiltrates in the upper aerodigestive tracts, particularly the nasal cavity and salivary glands.

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