Whole-body MRI added to gadoxetic acid-enhanced liver MRI for detection of extrahepatic disease in patients considered eligible for hepatic resection and/or local ablation of colorectal cancer liver metastases

2019 ◽  
Vol 61 (2) ◽  
pp. 156-167
Author(s):  
Kim Sivesgaard ◽  
Lars P Larsen ◽  
Michael Sørensen ◽  
Stine Kramer ◽  
Sven Schlander ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Fdg Pet ◽  
Colorectal Liver Metastases ◽  
Local Treatment ◽  
Whole Body ◽  
Extrahepatic Disease ◽  
Liver Mri ◽  
Whole Body Mri ◽  
Pet Ct ◽  
Fdg Pet Ct

Background Fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) can detect extrahepatic disease before local treatment of colorectal liver metastases. Purpose To investigate if whole-body magnetic resonance imaging (MRI) added to gadoxetic acid liver MRI could replace FDG-PET/CT for detection of extrahepatic disease in patients with colorectal liver metastases eligible for hepatic local treatment. Material and Methods This health-research-ethics-committee-approved prospective consecutive diagnostic accuracy study with written informed consent analyzed 79 cases included between 29 June 2015 and 7 February 2017. Whole-body MRI covering the thorax, abdomen, and pelvis and FDG-PET/CT including contrast-enhanced CT was performed 0–3 days before local treatment of liver metastases. Whole-body MR images were read independently by two readers. FDG-PET/CT images were read independently by two pairs of readers. Histopathology and follow-up imaging were used as reference standard. Sensitivities and specificities were calculated and compared including noninferiority analysis. Results Seventy-five malignant lesions and 419 benign lesions were confirmed. Sensitivities of both PET/CT reader pairs 1 and 2 (56.7 and 67.9%) and MRI reader 2 (63.0%) were significantly higher than that of MRI reader 1 (42.7) (P<0.04). Specificities of both PET/CT reader pairs 1 and 2 (92.5 and 92.4%) and MRI reader 1 (91.1%) were significantly higher than that of MRI reader 2 (86.3%) ( P < 0.02). Sensitivity of MRI reader 2 was non-inferior compared to PET/CT reader pair 1. Specificities of both MRI readers were non-inferior to both PET/CT reader pairs. Conclusion For detection of extrahepatic disease in patients with colorectal liver metastases, whole-body MRI was non-inferior to FDG-PET/CT for some reader combinations. However, reader-independent non-inferiority could not be demonstrated.

The use of 18F-FDG PET/CT in colorectal liver metastases—comparison with CT and liver MRI

2008 ◽  
Vol 35 (7) ◽  
pp. 1323-1329 ◽  
Author(s):  
G. Kong ◽  
C. Jackson ◽  
D. M. Koh ◽  
V. Lewington ◽  
B. Sharma ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Fdg Pet ◽  
Colorectal Liver Metastases ◽  
Liver Mri ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals The influence of FDG PET-CT on the detection of extrahepatic disease in patients being considered for resection of colorectal liver metastasis

2014 ◽  
Vol 96 (3) ◽  
pp. 211-215 ◽  
Author(s):  
ES Lake ◽  
S Wadhwani ◽  
D Subar ◽  
A Kauser ◽  
C Harris ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Liver Metastases ◽  
Colorectal Liver Metastasis ◽  
Fdg Pet ◽  
Colorectal Liver Metastases ◽  
Extrahepatic Disease ◽  
Nodal Disease ◽  
Ct Findings ◽  
Pet Ct ◽  
Fdg Pet Ct

Introduction The aim of this study was to evaluate the influence of flurodeoxyglucose positron emission tomography computed tomography (FDG PET-CT), as an adjunct to conventional CT staging, in the detection of extrahepatic disease in patients with potentially resectable colorectal liver metastasis. Methods Overall, 133 consecutive patients with colorectal liver metastases staged with CT and PET-CT referred to the East Lancashire regional hepatobiliary multidisciplinary team over a two-year period were included in this study. Abnormal findings on PET-CT were correlated with follow-up imaging and/or histology. All imaging was reviewed by specialist hepatobiliary radiologists for the presence/absence of extrahepatic disease. The influence of the PET-CT findings was categorised for each patient in relation to operability and other significant findings. Results PET-CT had a major impact on staging of extra hepatic disease in 20% of patients, in comparison with the initial CT. Six per cent of patients were upstaged from operable CT findings to inoperable findings on PET-CT because of the discovery of inoperable occult extrahepatic disease. Five per cent had operable local regional nodal disease detected on PET-CT. A further 3% had premalignant colorectal lesions detected on PET-CT. Six per cent of patients were downstaged from indeterminate or suspected inoperable CT findings to operable findings on PET-CT. Conclusions The use of PET-CT in this setting may prevent futile operations, guide the resection of local regional nodal disease and downstage a number of patients thought to have extrahepatic disease on conventional imaging. This study has shown similar results to other recent studies and supports the use of PET-CT as a necessary staging modality in patients with potentially resectable colorectal liver metastases.

15 ORAL Does 18F-FDG PET/CT alter the management of patients with colorectal liver metastases?

2006 ◽  
Vol 32 ◽  
pp. S6
Author(s):  
F. Pakzad ◽  
A. Engledow ◽  
S. Rogers ◽  
J.B. Bomanji ◽  
P.J. Ell ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Fdg Pet ◽  
Colorectal Liver Metastases ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Diagnostic performance of the FDG PET/CT in patients with mucinous colorectal liver metastases

HPB ◽  
2018 ◽  
Vol 20 ◽  
pp. S345-S346
Author(s):  
N. Russolillo ◽  
A. Borello ◽  
S. Langella ◽  
R. Lo Tesoriere ◽  
F. Forchino ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Fdg Pet ◽  
Colorectal Liver Metastases ◽  
Diagnostic Performance ◽  
Pet Ct ◽  
Fdg Pet Ct

Whole-body MRI for initial staging of paediatric lymphoma: prospective comparison to an FDG-PET/CT-based reference standard

2014 ◽  
Vol 24 (5) ◽  
pp. 1153-1165 ◽  
Author(s):  
Annemieke S. Littooij ◽  
Thomas C. Kwee ◽  
Ignasi Barber ◽  
Claudio Granata ◽  
Malou A. Vermoolen ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Whole Body ◽  
Reference Standard ◽  
Whole Body Mri ◽  
Prospective Comparison ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Initial Staging

The metabolic clinical risk score (mCRS) as a new prognostic model for surgical decision in patients with colorectal liver metastases.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e15094-e15094
Author(s):  
Ivan Duran Derijckere ◽  
Hugo Levillain ◽  
Ali Bohlok ◽  
Celine Mathey ◽  
Jonathan Nezri ◽  
...  
Keyword(s):  
High Risk ◽  
Liver Metastases ◽  
Risk Score ◽  
Fdg Pet ◽  
Colorectal Liver Metastases ◽  
Clinical Risk Score ◽  
Clinical Risk ◽  
Pet Ct ◽  
Selection For ◽  
Fdg Pet Ct

e15094 Background: Selection for surgery in patients with colorectal liver metastases (CRLM) remains poorly accurate. We evaluated if baseline metabolic characteristics of CRLM, as assessed by [18]-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18FDG-PET/CT), may predict the postoperative outcome in patients operated for CRLM. Methods: In a series of 450 patients operated for CRLM, we retrospectively identified 2 groups: The long-term survival (LTS), as defined by postoperative recurrence-free survival (RFS)≥5 years, and the early relapse groups (ER), as defined by RFS < 1 year. Clinicopathologic characteristics, Clinical Risk Score (CRS) and baseline 18FDG-PET/CT metabolic parameters were analyzed. Baseline 18FDG-PET/CT was performed at the time of diagnosis of CRLM, before any preoperative treatment. Low and high-risk CRS were defined by scores of 0 to 2 and 3 to 5, respectively. Metabolic CRS (mCRS) was implemented, using 1 additional point to the standard CRS when the highest tumor standardized uptake value (SUVmax) and normal liver mean SUV (SUVmean(liver)) ratio was > 4.3. Low and high-risk mCRS were defined by scores of 0 to 2 and 3 to 6, respectively. Results: We analyzed 53 patients. No difference was observed between LTS (n = 23) and ER (n = 30) groups for clinicopathologic parameters related to the primary tumor and CRLM, CRS and rates of low/high risk CRS. All metabolic parameters analyzed, including SUVmax and SUVpeak, at the exception of metabolic tumor volume, were significantly increased in ER group. Median SUVmax/SUVmean(liver) ratio was significantly increased in the ER vs LTS, respectively of 4.2 and 2.8 (p = 0.008). mCRS was significantly higher in ER as compared to LTS patients (p = 0.024), while 61% of the LTS patients had a low-risk mCRS and 73% of the ER patients had a high-risk mCRS (p = 0.023). Conclusions: Baseline 18FDG-PET/CT characteristics demonstrate an increased tumor glucose uptake in patients who rapidly recur after curative-intent surgery for CRLM. The introduction of these data into clinical risk model may represent a new tool to improve selection for surgery in patients with CRLM.

Pilot Prospective Evaluation of 99mTc-MDP Scintigraphy, 18F NaF PET/CT, 18F FDG PET/CT and Whole-Body MRI for Detection of Skeletal Metastases

2013 ◽  
Vol 38 (7) ◽  
pp. e290-e296 ◽  
Author(s):  
Andrei Iagaru ◽  
Phillip Young ◽  
Erik Mittra ◽  
David W. Dick ◽  
Robert Herfkens ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Whole Body ◽  
Skeletal Metastases ◽  
Prospective Evaluation ◽  
Whole Body Mri ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

425. The Decisive Role of FDG PET-CT in the Follow-up of RFA-treated Colorectal Liver Metastases

2012 ◽  
Vol 38 (9) ◽  
pp. 855-856
Author(s):  
K. Nielsen ◽  
A.A.J.M. van Tilborg ◽  
M.R. Meijerink ◽  
S. Meijer ◽  
E.F.I. Comans ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Fdg Pet ◽  
Colorectal Liver Metastases ◽  
Decisive Role ◽  
Pet Ct ◽  
Fdg Pet Ct
Sign in / Sign up

Export Citation Format

Share Document