Methylphenidate and substance abuse: A review of pharmacology, animal, and clinical studies

2002 ◽  
Vol 6 (1_suppl) ◽  
pp. 65-71 ◽  
Author(s):  
M. Huss ◽  
U. Lehmkuhl
Keyword(s):  
Substance Abuse ◽  
Attention Deficit Hyperactivity Disorder ◽  
Substance Use ◽  
Attention Deficit ◽  
Prospective Studies ◽  
Lower Risk ◽  
Abuse Liability ◽  
Long Term Effects ◽  
Hyperactivity Disorder

This article reviews pharmacological, animal, and human evidence regarding the abuse liability of methylphenidate (MPH). Findings are not always consistent, but evidence converges to suggest that although intravenous methylphenidate has some abuse potential, there is very little potential for oral MPH abuse. Furthermore, the available data suggests that children with Attention-Deficit/Hyperactivity Disorder (ADHD) who are treated with MPH are at lower risk for substance use disorder later in life. More longitudinal, prospective studies are needed to assess the long term effects of MPH treatment in ADHD.

scholarly journals Long-term Effects of Multimodal Treatment on Adult Attention-Deficit/Hyperactivity Disorder Symptoms

2019 ◽  
Vol 2 (5) ◽  
pp. e194980 ◽  
Author(s):  
Alexandra P. Lam ◽  
Swantje Matthies ◽  
Erika Graf ◽  
Michael Colla ◽  
Christian Jacob ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Multimodal Treatment ◽  
Long Term Effects ◽  
Hyperactivity Disorder

scholarly journals Predicting substance use disorder using long-term attention deficit hyperactivity disorder medication records in Truven

2019 ◽  
Vol 26 (2) ◽  
pp. 787-802 ◽  
Author(s):  
Sajjad Fouladvand ◽  
Emily R Hankosky ◽  
Heather Bush ◽  
Jin Chen ◽  
Linda P Dwoskin ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Substance Use ◽  
Substance Use Disorder ◽  
Attention Deficit ◽  
Health Consequences ◽  
Hyperactivity Disorder ◽  
Long Term Impact

About 20% of individuals with attention deficit hyperactivity disorder are first diagnosed during adolescence. While preclinical experiments suggest that adolescent-onset exposure to attention deficit hyperactivity disorder medication is an important factor in the development of substance use disorder phenotypes in adulthood, the long-term impact of attention deficit hyperactivity disorder medication initiated during adolescence has been largely unexplored in humans. Our analysis of 11,624 adolescent enrollees with attention deficit hyperactivity disorder in the Truven database indicates that temporal medication features, rather than stationary features, are the most important factors on the health consequences related to substance use disorder and attention deficit hyperactivity disorder medication initiation during adolescence.

scholarly journals Pharmacogenetics of methylphenidate in childhood attention-deficit/hyperactivity disorder: long-term effects

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Clara I. Gomez-Sanchez ◽  
Juan J. Carballo ◽  
Rosa Riveiro-Alvarez ◽  
Victor Soto-Insuga ◽  
Maria Rodrigo ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Long Term Effects ◽  
Hyperactivity Disorder
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