Effects of Hypericum Extract LI 160 Compared with Maprotiline on Resting EEG and Evoked Potentials in 24 Volunteers

1994 ◽  
Vol 7 (1_suppl) ◽  
pp. 44-46 ◽  
Author(s):  
D. Johnson ◽  
H. Ksciuk ◽  
H. Woelk ◽  
E. Sauerwein-Giese ◽  
A. Frauendorf
Keyword(s):  
Evoked Potentials ◽  
Healthy Volunteers ◽  
Cognitive Functions ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Acoustic Evoked Potentials ◽  
Hypericum Extract

In a randomized double-blind study, the effect of hypericum extract was compared to that of maprotiline in 24 healthy volunteers. The investigations included measurements of resting EEG as well as visual and acoustic evoked potentials. In resting EEGs, both medications revealed oppositely directed changes in the theta frequencies, and mainly similarly directed changes in alpha and beta frequencies. Measurements of evoked potentials in the theta and beta frequencies supported these results. The results indicate improved cognitive functions mainly with the treatment of hypericum extract.

Pharmacological Modulation of Cutaneous Reactivity to Histamine: A Double-Blind Acute Comparative Study between Cetirizine, Terfenadine and Astemizole

1989 ◽  
Vol 17 (1) ◽  
pp. 24-27 ◽  
Author(s):  
L. Ghys ◽  
J.-P. Rihoux
Keyword(s):  
Comparative Study ◽  
Healthy Volunteers ◽  
Inhibitory Effect ◽  
Blind Study ◽  
Double Blind Study ◽  
Single Administration ◽  
Double Blind ◽  
Pharmacological Modulation ◽  
The Difference ◽  
Cutaneous Reactivity

In a double-blind study performed in 81 healthy volunteers, 10 mg cetirizine and 60 mg terfenadine given orally in a single administration significantly inhibited skin reactivity to histamine. Astemizole (10 mg) was completely ineffective. The inhibitory effect of cetirizine was potent and regular whereas 6/28 (21%) volunteers did not respond to terfenadine. The difference observed beween cetirizine and terfenadine might be due to differences in the metabolism of the two drugs after administration: terfenadine is rapidly and extensively metabolized whereas cetirizine is directly active without the need for biotransformation and, indeed is poorly metabolized.

scholarly journals The Effects of Mirtazapine on Sleep: A Placebo Controlled, Double-Blind Study in Young Healthy Volunteers

SLEEP ◽  
2002 ◽  
Vol 25 (6) ◽  
pp. 666-668 ◽  
Author(s):  
Selcuk Aslan ◽  
Erdal Isik ◽  
Behcet Cosar
Keyword(s):  
Healthy Volunteers ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind

scholarly journals Bioequivalence of Two Prolonged-Release Diclofenac Sodium Formulations in Healthy Volunteers: A Randomized, Crossover, Double-Blind Study

2017 ◽  
Vol 09 (06) ◽  
Author(s):  
Gonzalez Delgado CA ◽  
Padron Yaquis AS ◽  
Jimenez Rodriguez D ◽  
Cazanave Guarnaluce D ◽  
Alejo Cisneros PL ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Diclofenac Sodium ◽  
Blind Study ◽  
Prolonged Release ◽  
Double Blind Study ◽  
Double Blind

scholarly journals Double Blind Study of Melatonin Effects on the Sleep-wake Rhythm, Cognitive and Non-cognitive Functions in Alzheimer Type Dementia

2003 ◽  
Vol 70 (4) ◽  
pp. 334-341 ◽  
Author(s):  
Kentaro Asayama ◽  
Hiroshi Yamadera ◽  
Takao Ito ◽  
Hideaki Suzuki ◽  
Yoshihisa Kudo ◽  
...  
Keyword(s):  
Cognitive Functions ◽  
Blind Study ◽  
Double Blind Study ◽  
Alzheimer Type ◽  
Double Blind ◽  
Alzheimer Type Dementia
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