Nitroimidazoles Part 6. Synthesis, Structure and in Vitro anti-HIV Activity of New 5-substituted Piperazinyl-4-nitroimidazole Derivatives
2007 ◽
Vol 18
(4)
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pp. 191-200
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Keyword(s):
Anti Hiv
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2-Amino-1-[4-(1-benzyl-2-ethyl-4-nitro-1 H-imidazol-5-yl)piperazin-1-yl]ethanone [6] was prepared from 1-(1-benzyl-2-ethyl-4-nitro-1 H-imidazol-5-yl) piperazine [3]. A series of new 2-oxoethyl-arylamide [9,10] and 2-oxoethyl-arylsulphonamide [11–14] derivatives were synthesized from [6] with the aim of developing new non-nucleoside reverse transcriptase inhibitors. Alternatively, the amine [17] was synthesized from [3] via the phthalimide derivative [16]. The arylsulphonamide derivatives [18–23] and the arylamide analogues [24–26] were synthesized from [17]. The compounds were evaluated for their anti-HIV-1 and anti-HIV-2 activity in MT-4 cells.
2004 ◽
Vol 47
(4)
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pp. 928-934
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2010 ◽
Vol 18
(14)
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pp. 5039-5047
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2009 ◽
Vol 44
(3)
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pp. 1016-1023
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2005 ◽
Vol 48
(19)
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pp. 6140-6155
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2005 ◽
Vol 732
(1-3)
◽
pp. 39-45
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1999 ◽
Vol 7
(12)
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pp. 2811-2822
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1997 ◽
Vol 40
(6)
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pp. 847-853
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2020 ◽
Vol 17
(6)
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pp. 818-825