Small-Volume Unit Dose Packaging

1977 ◽  
Vol 11 (2) ◽  
pp. 109-109
Author(s):  
John P. Swenson
Keyword(s):  
1976 ◽  
Vol 10 (8) ◽  
pp. 467-467
Author(s):  
Charles O. Skaggs
Keyword(s):  

Gut ◽  
2012 ◽  
Vol 61 (Suppl 2) ◽  
pp. A286.2-A287
Author(s):  
M Yiasemidou ◽  
S Stock
Keyword(s):  

Pharmaceutics ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 91
Author(s):  
Shu-Hsin Chen ◽  
Hsiu-Chu Chang ◽  
Ming-Yi Chien ◽  
Jinxiang Xi ◽  
Hui-Ling Lin

This study aimed to evaluate optimal aerosol and oxygen delivery with a hood on an infant model and a paediatric model. A facemask and a hood with three inlets, with or without a front cover, were used. A small-volume nebuliser with a unit-dose of salbutamol was used for drug delivery and an air entrainment nebuliser was used to deliver oxygen at 35%. Infant and paediatric breathing patterns were mimicked; a bacterial filter was connected to the end of a manikin trachea for aerosol drug collection, and an oxygen analyser was used to measure the oxygen concentration. For the infant model, inhaled drug dose was significantly higher when the nebuliser was placed in the back of the hood and with a front cover. This was verified by complementary computational simulations in a comparable infant-hood model. For the paediatric model, the inhaled dose was greater with a facemask than with a hood. Oxygen delivery with a facemask and a hood with a front cover achieved a set concentration in both models, yet a hood without a front cover delivered oxygen at far lower concentrations than the set concentration.


2008 ◽  
Vol 78 (3) ◽  
pp. 128-133 ◽  
Author(s):  
Vincent B. Nieuwenhuijs ◽  
John W. Chen ◽  
Libby John ◽  
John Ring ◽  
Hugh Harley ◽  
...  

Author(s):  
D.P. Bazett-Jones ◽  
F.P. Ottensmeyer

Dark field electron microscopy has been used for the study of the structure of individual macromolecules with a resolution to at least the 5Å level. The use of this technique has been extended to the investigation of structure of interacting molecules, particularly the interaction between DNA and fish protamine, a class of basic nuclear proteins of molecular weight 4,000 daltons.Protamine, which is synthesized during spermatogenesis, binds to chromatin, displaces the somatic histones and wraps up the DNA to fit into the small volume of the sperm head. It has been proposed that protamine, existing as an extended polypeptide, winds around the minor groove of the DNA double helix, with protamine's positively-charged arginines lining up with the negatively-charged phosphates of DNA. However, viewing protamine as an extended protein is inconsistent with the results obtained in our laboratory.


Author(s):  
E. Zeitler ◽  
M. G. R. Thomson

In the formation of an image each small volume element of the object is correlated to an areal element in the image. The structure or detail of the object is represented by changes in intensity from element to element, and this variation of intensity (contrast) is determined by the interaction of the electrons with the specimen, and by the optical processing of the information-carrying electrons. Both conventional and scanning transmission electron microscopes form images which may be considered in this way, but the mechanism of image construction is very different in the two cases. Although the electron-object interaction is the same, the optical treatment differs.


Sign in / Sign up

Export Citation Format

Share Document