Fatal Bleeding Due to a Heparin-Like Anticoagulant in a 37-Year-Old Woman Suffering From Systemic Mastocytosis

2008 ◽  
Vol 14 (3) ◽  
pp. 360-364 ◽  
Author(s):  
Christoph Sucker ◽  
Georg Mansmann ◽  
Stefan Steiner ◽  
Norbert Gattermann ◽  
Anette Schmitt-Graeff ◽  
...  
Keyword(s):  
Female Patient ◽  
Clinical Presentation ◽  
Systemic Mastocytosis ◽  
Therapeutic Options ◽  
Refractory Disease ◽  
Fatal Bleeding ◽  
Laboratory Procedures

A 37-year-old female patient with systemic mastocytosis who was admitted with severe unexplained bleeding symptoms is studied. Laboratory procedures established the diagnosis of a patient-derived—heparin-like anticoagulant as a very rare hemostatic abnormality predisposing to bleeding. The patient died from refractory disease despite therapy with protamine, initiation of chemotherapy, and supportive measures. The case illustrates the clinical presentation and diagnosis of heparin-like anticoagulants. Etiology, pathophysiology, and therapeutic options are discussed.

scholarly journals Hernia gástrica atascada en ventana pericardio-peritoneal. Una rara complicación

2020 ◽  
Vol 112 (2) ◽  
pp. 193-196
Author(s):  
José A Acevedo ◽  
◽  
Julio G. Caballero ◽  
Alejandra Lencinas ◽  
Martín Córdoba ◽  
...  
Keyword(s):  
Pericardial Effusion ◽  
Female Patient ◽  
Aspiration Pneumonia ◽  
Clinical Presentation ◽  
Therapeutic Options ◽  
Peritoneal Window

We report the case of a 73-year- old female patient with vomiting, aspiration pneumonia and constitutional symptoms. The imaging tests showed total gastric herniation in the pericardial sac through a pericardio-peritoneal window previously created. The case was solved with surgery. The therapeutic options for persistent pericardial effusion are considered. Intrapericardial gastric hernia as a complication, its clinical presentation, intraoperative findings, complementary tests and treatment are discussed.

Female Patient with Simultaneous Occurrence of Subacute Thyroiditis and Focal Autonomy

2019 ◽  
Vol 58 (05) ◽  
pp. 401-402
Author(s):  
Christina Loberg ◽  
Dirk Mallek ◽  
Felix M. Mottaghy ◽  
Mohsen Beheshti ◽  
Alexander Heinzel
Keyword(s):  
Emergency Department ◽  
Sore Throat ◽  
Female Patient ◽  
Clinical Presentation ◽  
Subacute Thyroiditis ◽  
Simultaneous Occurrence ◽  
Severe Diarrhea ◽  
Loss Of Appetite

Clinical presentationA 57-year-old female patient presented at the emergency department with fatigue, increased sweating, flushing symptoms, loss of appetite, drowsiness and severe diarrhea. Besides she also mentioned painful left-sided sore throat radiating to the temples, beginning two weeks after a flu and subfebrile temperatures.

scholarly journals Papillon lefevre syndrome- An imperative role of periodontist

2016 ◽  
Vol 4 (1) ◽  
pp. 5
Author(s):  
Prathypaty Santha Kumari ◽  
Guvvala Satheesh Kumar ◽  
Potharaju Santhi priya ◽  
Yendluri Durga Bai ◽  
Sahithi Dathar
Keyword(s):  
Female Patient ◽  
Autosomal Recessive ◽  
Clinical Presentation ◽  
Autosomal Recessive Inheritance ◽  
Permanent Dentition ◽  
Recessive Inheritance

<p>Papillon Lefevre syndrome (PLS) is a rarely encountered disorder that shows autosomal recessive inheritance. Clinically, it exhibits hyperkeratotic plaques on palmar plantar surfaces, severe periodontal loss and precocious shedding of primary as well as permanent dentition. The reason for this exceptional clinical presentation is vague and speculative. We are reporting one such case of a 23year old female patient.</p>

Polysomnography

2017 ◽  
Author(s):  
Sudhansu Chokroverty ◽  
Roberto Vertugno
Keyword(s):  
Neurological Disorders ◽  
Clinical Presentation ◽  
Sleep Latency ◽  
Clinical Aspects ◽  
Physiological Changes ◽  
Functional Neuroanatomy ◽  
Maintenance Of Wakefulness Test ◽  
Laboratory Procedures ◽  
Clinical Considerations ◽  
Multiple Sleep Latency

This chapter covers the technical and clinical aspects of polysomnography (PSG). Section 1 includes a brief review of the historical milestones, functional neuroanatomy of sleep, physiological changes (emphasizing those pertinent to overnight PSG interpretation) and clinical relevance as well as homeostatic and circadian factors, and functions of sleep. Section 2 deals with laboratory procedures, including PSG recording and scoring techniques, indications for PSG, video-PSG, ambulatory and computerized PSG, artifacts during PSG recording, and pitfalls of PSG. Section 3 includes clinical considerations, briefly describing the clinical presentation, diagnosis, and treatment but mainly focusing on PSG findings in common sleep disorders as well as sleep-related movement disorders, neurological disorders, and sleep-related epilepsies. Section 4 addresses related laboratory procedures for the assessment of sleep, including the multiple sleep latency test, the maintenance-of-wakefulness test, and actigraphy.

scholarly journals Psoriatic Alopecia in a Patient with Systemic Lupus Erythematosus

2017 ◽  
Vol 9 (1) ◽  
pp. 51-59 ◽  
Author(s):  
Wimolsiri Iamsumang ◽  
Tueboon Sriphojanart ◽  
Poonkiat Suchonwanit
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Female Patient ◽  
Hair Loss ◽  
Lupus Erythematosus ◽  
Clinical Presentation ◽  
Scalp Hair ◽  
Clinical Manifestations ◽  
Systemic Lupus ◽  
Scalp Psoriasis ◽  
Histopathologic Findings

Psoriasis is a chronic, recurrent, and relatively common inflammatory dermatologic condition, which demonstrates various clinical manifestations including hair loss. It was once believed that alopecia was not a presentation of scalp psoriasis, but it is now widely accepted that psoriatic alopecia exists. Although the majority of patients get hair regrowth, it can potentially lead to permanent hair loss. Herein, we report a case of 26-year-old female patient with systemic lupus erythematosus who presented with scalp hair loss and nonpruritic scaly plaques on the scalp. Her clinical presentation, dermoscopic, and histopathologic findings were consistent with psoriatic alopecia. Additionally, we also described a novel scalp dermoscopic pattern of “patchy dotted vessels” which we detected in the lesion of scalp psoriasis.

Prolactinomas Clinical Presentation, Radiologic Assessment, and Therapeutic Options

1985 ◽  
Vol 20 (4) ◽  
pp. 345-354 ◽  
Author(s):  
CAROL A. HANKINS ◽  
AMIR A. ZAMANI ◽  
CALVIN L. RUMBAUGH
Keyword(s):  
Clinical Presentation ◽  
Therapeutic Options ◽  
Radiologic Assessment

Presentation of Telangiectasia Macularis Eruptiva Perstans as a Long-Standing Solitary Plaque Associated with Renal Carcinoma

2003 ◽  
Vol 7 (5) ◽  
pp. 399-402 ◽  
Author(s):  
José Carlos Pascual ◽  
José Bañuls ◽  
Ma Pilar Albares ◽  
Gloria Vergara ◽  
Isabel Belinchón ◽  
...  
Keyword(s):  
Renal Carcinoma ◽  
Clinical Presentation ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Systemic Mastocytosis ◽  
Malignant Neoplasm ◽  
Renal Clear Cell Carcinoma ◽  
Good Prognosis ◽  
Uncertain Significance ◽  
Cutaneous Mastocytosis

Background: Mastocytosis is a rare disease characterized by a primary pathological increase in mast cells in different tissues. The skin is the most frequently affected organ. Cutaneous mastocytosis, including urticaria pigmentosa, solitary mastocytoma, diffuse cutaneous mastocytosis, and telangiectasia macularis eruptiva perstans (TMEP), is usually distinguished from systemic mastocytosis. TMEP is characterized mainly by telangiectatic macules. Objective and Methods: We report a case of TMEP with an unusual clinical presentation as a solitary plaque of telangiectatic macules. A renal clear cell carcinoma was detected in a workup for systemic mastocytosis. We discuss the clinical and histological findings and treatment of TMEP. Conclusions: TMEP is a rare form of mastocytosis, which occurs mainly in adults, generally has a good prognosis, and little tendency to urticate or show constitutional symptoms. Clinicians should consider this disorder when confronted with a progressive atypical telangiectatic lesion. However, the malignant neoplasm also found in this patient is of uncertain significance.

scholarly journals Very Early Onset Pancreatic Adenocarcinoma - Clinical Presentation, Risk Factors and Therapeutic Options

Chirurgia ◽  
2018 ◽  
Vol 113 (3) ◽  
pp. 405 ◽  
Author(s):  
Ștefania Bunduc ◽  
Răzvan Iacob ◽  
Roxana Costache ◽  
Bianca Stoica ◽  
Cristina Radu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pancreatic Adenocarcinoma ◽  
Early Onset ◽  
Clinical Presentation ◽  
Therapeutic Options

scholarly journals Primary aspergilloma and subacute invasive aspergillosis in two AIDS patients

2009 ◽  
Vol 51 (1) ◽  
pp. 49-52 ◽  
Author(s):  
Roberto Martinez ◽  
Gleusa de Castro ◽  
Alcyone A. Machado ◽  
Maria Janete Moya
Keyword(s):  
Invasive Aspergillosis ◽  
Female Patient ◽  
Antifungal Therapy ◽  
Clinical Presentation ◽  
Brain Lesions ◽  
Antifungal Treatment ◽  
Lung Involvement ◽  
Aids Patients ◽  
History Of ◽  
Cd4 Lymphocyte

Although uncommon, invasive aspergillosis in the setting of AIDS is important because of its peculiar clinical presentation and high lethality. This report examines two AIDS patients with a history of severe cellular immunosuppression and previous neutropenia, who developed subacute invasive aspergillosis. One female patient developed primary lung aspergilloma, with dissemination to the mediastinum, vertebrae, and spine, which was fatal despite antifungal treatment. The second patient, who had multiple cavitary brain lesions, and eye and lung involvement, recovered following voriconazole and itraconazole, and drugs for increasing neutrophil and CD4+ lymphocyte levels. These cases demonstrate the importance of Aspergillus infections following neutropenia in AIDS patients, and emphasize the need for early and effective antifungal therapy.

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