Rare Earth Elements Accumulation in the Hair of Malagasy Children and Adolescents in Relation to Their Age and Nutritional Status

Due to undesired influence, the accumulation of rare earth elements (REE) in the human body has been discussed recently. However, it is usually limited to the study of the population living where REE ores and mines are located. The aim of the experiment presented was to analyse the concentration of REE in the hair of children and teenagers living in two areas of Madagascar in relation to the place of residence, nutritional status, age and sex. REE concentration was determined in scalp hair of 262 of subjects (5–19 years old) by an inductively coupled plasma-optical emission spectrometer. The content of total REE in the Malagasy hair was in the range of 0.79–44.15 mg/kg. The nutritional status was evaluated by Cole’s index, and malnutrition of children was observed more often in village areas. The concentration of these elements was also determined in 20 samples for the estimation of environmental exposure. No significant differences were detected in the content of these elements in the studied regions, although the mean value was always higher in soil samples from the Antananariva region. The obtained data suggest dependence between REE concentration in the hair and age, and nutritional status of the examined subjects. Even if the observed correlations are weak, they contribute significant knowledge on the accumulation of REE in the bodies of children living in areas that are not recognised as deposits of these elements.

Frameshift Variant in ARID2 in a Chilean Individual with Coffin–Siris Syndrome Phenotype

Coffin–Siris syndrome (CSS) is one of the several causes of intellectual disability (ID) and, since its first description, has posed diagnostic challenges given its variability and phenotypic overlap with other alterations of chromatin-remodeling-associated syndromes. It is genetically heterogeneous, and causative mutations are detected in less than 70% of cases. The different subtypes of the syndrome described to date are caused by mutations in genes that encode subunits of the SWI/SNF chromatin-remodeling complex, which plays an essential role in the regulation of gene expression during embryogenesis. Whole exome sequencing (WES) has allowed the identification of pathogenic mutations in these genes, including ARID2. ARID2 is one of the primary components of the SWI/SNF complex and has been associated with ID and phenotypes similar to CSS for the first time in 2015. Fifteen published case reports have identified loss-of-function mutations, suggesting that the underlying pathogenic disease mechanism is haploinsufficiency of ARID2.We herein presented the case of an 8-year-old Chilean girl with clinical suspicion of CSS, in whom a novel frameshift variant in ARID2 was identified by WES. She was the first reported case in Latin America to our knowledge and her phenotype displays the main clinical features suggestive of CSS described in other patients with ARID2 variants. However, she did not present behavioral abnormalities, a characteristic frequently reported in the majority of patients with ARID2 variants, and also had some features, such as sparse scalp hair, which is frequently reported as a manifestation of CSS, but is uncommon in this new group of patients.

Using Nonscalp Hair in Scalp Hair Restoration—Theory and Execution

Harvesting of beard and body hair follicles for transplantation can be an effective form of treatment for appropriate patients. These patients may have had prior scalp transplantation and require repair but do not have sufficient scalp donor follicles remaining. Other patients will have these hairs mixed with scalp hairs to produce a greater density of hair on the bald scalp. Follicular unit excision (FUE) is preferred for body and beard follicle harvesting. Not all body hair is suitable for transplantation. Only hairs that are similar in appearance and behavior to scalp hair are suitable for transplantation to the scalp. The best nonscalp sources are the beard and anterior torso. Hairs from other body sites may be used for transplantation to the eyebrows. The standard techniques of FUE harvesting and anesthesia must be modified from those used in scalp harvesting to be safe and effective. With proper patient selection and technique, a significant cosmetic benefit can be achieved from these procedures.

Concentration of selected elements in the hair of Madagascar girls in relation to nutritional status and place of residence

Although the children malnutrition in Madagascar and the environmental pollution of this country has been widely discussed, there is no research on the differences in toxic elements accumulation in human body in dependence on nutritional status of Malagasy. Nine elements concentration (Al, As, Cd, Cr, Hg, Ni, Pb, Sn and Sb) was determined in scalp hair of 103 schoolgirls (8–15 years old), living in two areas: urban - close to Antananarivo (UR) and rural Berevo region (RU). Samples were analyzed by an inductively coupled plasma-optical emission spectrometer. The nutritional status was evaluated by Cole’s Index. Underweight was related to higher accumulation of Al, Cd, and Cr in the hair girls, and more common among girls living in RU than UR region (42% vs 28%). Two-factor analysis of variance showed differences in the Al and Cr content in the girls’ hair depending both on their place of residence and nutritional status. This indicates additional consequence of malnutrition to the girls development and health.

Scalp hair sweating as a predictor of hair cortisol level in human compared to obesity and other confounders

Inconsistent results were found throughout the literature regarding factors affecting hair cortisol levels. Hair cortisol level in humans was not studied for its associations to scalp hair sweating or hair wash frequency in a patient-based way. Factors affecting hair cortisol levels must be precisely known in order to interpret the results correctly. The aims of the study are to assess if BMI, Perceived Stress Scale (PSS), hair wash frequency, and sweating with scalp hair affect hair cortisol levels. It will assess which of these factors are more significant predictors of hair cortisol levels. In a study on healthy adults, information about history, socio-demographics, PSS, hair wash frequency, hair treatment, and scalp hair sweating were collected, and hair samples were taken and analyzed for their hair cortisol level. Associations of hair cortisol levels with each of the variables were investigated and significant predictors of hair cortisol levels among the variables were found. Mean hair cortisol level in the study participants was 16.84 pg/mg hair. Hair cortisol has a significant positive association with weight, BMI, PSS, and scalp hair sweating, p < 0.05. Scalp hair sweating significantly predicts hair cortisol levels by 12.3%, while other variables did not significantly predict hair cortisol levels, p < 0.05. Scalp hair sweating significantly predicts hair cortisol levels. Age, hair wash frequency, hair treatment, and stressful events have no associations with hair cortisol levels. Although BMI and PSS are associated with hair cortisol levels, they do not significantly predict it. Obesity is significantly associated with profuse sweating, thus the increase in hair cortisol levels in obese individuals could partly be the result of a higher incidence of sweating in these individuals. Thus, scalp hair sweating should be taken into consideration during the study and interpretation of hair cortisol levels.

Instrumental neutron activation analysis (INAA) of zinc concentrations in scalp hair and fingernails samples of Algerian females with breast cancer

In the present work, zinc levels were measured in scalp hair and fingernails in order to identify potential risk factors for breast cancer. The samples were collected from 40 Algerian breast cancer female patients and from 20 normal subjects matching the same age range. The concentration of zinc was analyzed using Instrumental neutron activation analysis technique (INAA). In scalp hair samples it was found in the range 119–792 μg/g for the normal subjects and in the range 82–806 μg/g for the patients, with an increase rate of 10.9%. The range of concentration of zinc in fingernails was found between 89 and 247 μg/g for normal subjects and between 75 and 276 μg/g for the patients with an increase rate of 2.5%. The influence of age on zinc concentration was also investigated. The obtained results show some consistency with those obtained by other groups.

Effect of Trichologist's Expertise on Scalp and Hair Care Service Usag

In modern society, the importance of scalp hair care is increasing. Therefore, we would like to suggest a direction for improving the expertise of trichologists as a way to meet the demand for customized scalp and hair care services. In this study, a total of 298 questionnaires were used as frequency analysis, factor analysis, reliability analysis, regression analysis, and correlation analysis data through SPSS 26.0. analyzed. The survey results regarding the use of scalp and hair care services are as follows. First, trichologist expertise was classified as a single factor, and service use intention was classified as perceived usefulness and subjective normative factors. Second, the higher the expertise of the trichologist, the greater the effect of the intention to use the scalp and hair care service on the perceived usefulness factor and the subjective normative factor. In conclusion, we hope that more research will be done to strengthen the expertise of the trichologist, a senior workforce in the rapidly evolving beauty and health care industry.