Corrigendum to “Intravenous Fluid Management Practices in Kidney Transplant Patients: A Multicenter Observational Cohort Pilot Study”

Background Limited evidence exists with regard to best practices in fluid management during kidney transplantation, which may directly affect the incidence of DGF. The authors of this study embarked on a collaborative observational multicenter pilot study to evaluate fluid administration practices in different transplant centers, with a focus on the relationship between total administered crystalloid volume and its association with DGF. Methods Twenty consecutive kidney transplant patients were included from 9 academic medical centers in the United States. One hundred eighty patients were included in the final cohort and variables were compared between patients with and without DGF. Administered crystalloid volume was the primary variable of interest; however, additional patient and surgical variables were compared between patients with and without DGF. Variation in crystalloid administration was explored between centers by comparing median administered crystalloid volumes per kilogram of body weight. Also, unadjusted and adjusted logistic regression analyses were performed to determine which variables were independently associated with DGF. Results Multivariable regression modeling demonstrated that cold ischemic time and ephedrine use during surgery were independently associated with DGF. There was no independent association between administered crystalloid volume and DGF. Conclusion In this study of patients having kidney transplantation, we did not find an independent association between administered crystalloid volume and DGF, although there was significant variability in crystalloid administration between centers. Our data suggest that DGF was driven mainly by surgical factors such as cold ischemic time. Ephedrine was also independently associated with DGF, which should be explored in future studies.

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Progression of Endothelial Dysfunction, Atherosclerosis, and Arterial Stiffness in Stable Kidney Transplant Patients: A Pilot Study

10.21203/rs.2.16074/v1 ◽

2019 ◽

Author(s):

Joey Junarta ◽

Nina Hojs ◽

Robin Ramphul ◽

Racquel Lowe-Jones ◽

Juan C Kaski ◽

...

Keyword(s):

Pilot Study ◽

Kidney Transplant ◽

Cardiovascular Event ◽

Intima Media Thickness ◽

Post Transplantation ◽

Vascular Abnormalities ◽

Transplant Patients ◽

Diabetes Status ◽

Kidney Transplant Patients ◽

Event Rates

Abstract Background Kidney transplant patients suffer from vascular abnormalities and high cardiovascular event rates, despite initial improvements post-transplantation. The nature of the progression of vascular abnormalities in the longer term is unknown. This pilot study investigated changes in vascular abnormalities over time in stable kidney transplant patients long after transplantation. Methods Brachial artery flow-mediated dilation (FMD), nitroglycerin-mediated dilation, carotid-femoral pulse wave velocity (cf-PWV), ankle-brachial pressure index, and common carotid artery intima-media thickness (CCA-IMT) were assessed in 18 kidney transplant patients and 17 controls at baseline and 3-6 months after. Results There was no difference in age (51±13 vs. 46±11; P=0.19), body mass index (26±5 vs. 25±3; P=0.49), serum cholesterol (4.54±0.96 vs. 5.14±1.13; P=0.10), systolic blood pressure (BP) (132±12 vs. 126±12; P=0.13), diastolic BP (82±9 vs. 77±8; P=0.10), or diabetes status (3 vs. 0; P=0.08) between transplant patients and controls. No difference existed in vascular markers between patients and controls at baseline. In transplant patients, FMD decreased (-1.52±2.74; P=0.03), cf-PWV increased (0.62±1.06; P=0.03), and CCA-IMT increased (0.35±0.53; P=0.02). No changes were observed in controls. Conclusions Markers of vascular structure and function worsen in the post-transplant period on long-term follow-up, which may explain the continued high cardiovascular event rates in this population.

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Pilot Study Comparing the Efficacy, Safety, Convertibility, and Tacrolimus Trough Levels of Twice-Daily Tacrolimus (Prograf) to Once-Daily Tacrolimus (Advagraf) Among Standard-Risk Kidney Transplant Patients at the National Kidney and Transplant Institute

Transplantation Proceedings ◽

10.1016/j.transproceed.2019.05.019 ◽

2019 ◽

Vol 51 (8) ◽

pp. 2615-2619

Author(s):

Romina A. Danguilan ◽

Arlene Lamban ◽

Glenda Eleanor P. Pamugas

Keyword(s):

Pilot Study ◽

Kidney Transplant ◽

Once Daily ◽

Transplant Patients ◽

Kidney Transplant Patients ◽

Standard Risk ◽

Trough Levels

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Ezetimibe treatment in hypercholesterolaemic kidney transplant patients is safe and effective and reduces the decline of renal allograft function: a pilot study

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfm620 ◽

2007 ◽

Vol 23 (1) ◽

pp. 369-373 ◽

Cited By ~ 19

Author(s):

T. R. Turk ◽

E. Voropaeva ◽

M. Kohnle ◽

J. Nurnberger ◽

T. Philipp ◽

...

Keyword(s):

Pilot Study ◽

Kidney Transplant ◽

Renal Allograft ◽

Transplant Patients ◽

Ezetimibe Treatment ◽

Allograft Function ◽

Kidney Transplant Patients

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Progression of Endothelial Dysfunction, Atherosclerosis, and Arterial Stiffness in Stable Kidney Transplant Patients: A Pilot Study

10.21203/rs.2.16074/v2 ◽

2019 ◽

Author(s):

Joey Junarta ◽

Nina Hojs ◽

Robin Ramphul ◽

Racquel Lowe-Jones ◽

Juan C Kaski ◽

...

Keyword(s):

Pilot Study ◽

Kidney Transplant ◽

Cardiovascular Event ◽

Intima Media Thickness ◽

Post Transplantation ◽

Vascular Abnormalities ◽

Transplant Patients ◽

Diabetes Status ◽

Kidney Transplant Patients ◽

Event Rates

Abstract Background Kidney transplant patients suffer from vascular abnormalities and high cardiovascular event rates, despite initial improvements post-transplantation. The nature of the progression of vascular abnormalities in the longer term is unknown. This pilot study investigated changes in vascular abnormalities over time in stable kidney transplant patients long after transplantation. Methods Brachial artery flow-mediated dilation (FMD), nitroglycerin-mediated dilation, carotid-femoral pulse wave velocity (cf-PWV), ankle-brachial pressure index, and common carotid artery intima-media thickness (CCA-IMT) were assessed in 18 kidney transplant patients and 17 controls at baseline and 3-6 months after. Results There was no difference in age (51±13 vs. 46±11; P=0.19), body mass index (26±5 vs. 25±3; P=0.49), serum cholesterol (4.54±0.96 vs. 5.14±1.13; P=0.10), systolic blood pressure (BP) (132±12 vs. 126±12; P=0.13), diastolic BP (82±9 vs. 77±8; P=0.10), or diabetes status (3 vs. 0; P=0.08) between transplant patients and controls. No difference existed in vascular markers between patients and controls at baseline. In transplant patients, FMD decreased (-1.52±2.74; P=0.03), cf-PWV increased (0.62±1.06; P=0.03), and CCA-IMT increased (0.35±0.53; P=0.02). No changes were observed in controls. Conclusions Markers of vascular structure and function worsen in the post-transplant period on long-term follow-up, which may explain the continued high cardiovascular event rates in this population.

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