Optic disc morphometry using spectral domain optical coherence tomography in a Nigerian population

Purpose: To assess morphological optic disc dimensions using spectral-domain optical coherence tomography (OCT) in a Nigerian population. Materials and method: Good quality SD-OCT scans of the optic disc of 147 eyes of 88 participants were selected, enrolled, and retrospectively reviewed. All subjects had optic nerve head and retinal nerve fibre layer OCT imaging, as well as analysis, done using the Topcon 3D OCT-1 Maestro®. The age, sex, and some OCT-generated optic disc dimensions namely disc area (DA), vertical disc diameter (VDD), horizontal disc diameter (HDD) were retrieved from the database and analyzed. Results: The mean age of the study subjects was 52.6±20.9 years with a range of 8–90 years; male to female ratio was 1:1.3. The right eye and left eye accounted for 75 and 72 of the 147 scans respectively. The mean DA, VDD, and HDD were 2.54 ± 0.48 mm2, 1926.5 ± 189.6 μm and 1673.9 ± 173.9 μm, respectively. Males had significantly larger DA than females (2.56 ± 0.53 mm2 vs 2.51 ± 0.44 mm2, p = 0.043). The mean DA and VDD of eyes of subjects aged 21–40 years were significantly higher compared to subjects aged 60 years and more ( p = 0.008 and 0.001, respectively). Conclusion: The mean optic disc area and diameters are larger than those reported in similar studies involving blacks and other races. The mean disc area reduces with increasing age.

Download Full-text

Comparison of Glaucoma Diagnostic Ability of Retinal Nerve Fibre Layer Thickness, Ganglionic Cell Complex Thickness and Optic Disc Measurements Made With the Spectral Domain Optical Coherence Tomography.

IOSR Journal of Dental and Medical Sciences ◽

10.9790/0853-1121116 ◽

2013 ◽

Vol 11 (2) ◽

pp. 11-16

Author(s):

Dr Chandrima Paul

Keyword(s):

Optical Coherence Tomography ◽

Layer Thickness ◽

Optic Disc ◽

Nerve Fibre ◽

Retinal Nerve Fibre Layer ◽

Spectral Domain ◽

Optical Coherence ◽

Diagnostic Ability ◽

Ganglionic Cell ◽

Nerve Fibre Layer

Download Full-text

The Effects of Race, Optic Disc Area, Age, and Disease Severity on the Diagnostic Performance of Spectral-Domain Optical Coherence Tomography

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.10-6698 ◽

2011 ◽

Vol 52 (9) ◽

pp. 6148 ◽

Cited By ~ 28

Author(s):

Christopher A. Girkin ◽

Jeffery Liebmann ◽

Murray Fingeret ◽

David S. Greenfield ◽

Felipe Medeiros

Keyword(s):

Optical Coherence Tomography ◽

Optic Disc ◽

Disease Severity ◽

Diagnostic Performance ◽

Spectral Domain ◽

Optical Coherence ◽

Disc Area

Download Full-text

Retinal nerve fibre layer thickness in a healthy Nepalese population by spectral domain optical coherence tomography

Nepalese Journal of Ophthalmology ◽

10.3126/nepjoph.v6i2.11709 ◽

2014 ◽

Vol 6 (2) ◽

pp. 131-139 ◽

Cited By ~ 5

Author(s):

Madhu Thapa ◽

Safal Khanal ◽

Gulsan B Shrestha ◽

Ananda K Sharma

Keyword(s):

Optical Coherence Tomography ◽

Layer Thickness ◽

Nerve Fibre ◽

Retinal Nerve Fibre Layer ◽

Spectral Domain ◽

Optical Coherence ◽

Rnfl Thickness ◽

The Mean ◽

Nerve Fibre Layer ◽

Sd Oct

Objective: To determine the normal values for peripapillary retinal nerve fibre layer thickness (RNFL) measured by spectral domain optical coherence tomography (SD- OCT) in a healthy Nepalese population and to compare the RNFL thicknesses between the genders and among the various age groups.Material and methods: One hundred and fifty six eyes of 156 healthy Nepalese subjects (66 males and 88 females) of various age groups were enrolled in this observational, cross-sectional, hospital-based study. The peripapillary RNFL of the randomly chosen eye of each subject was imaged with a high resolution SD-OCT (Spectralis HRA+OCT, Heidelberg Engineering). The RNFL thickness was measured around the optic nerve head using 16 automatically averaged, consecutive, circular B scans with a 3.4 mm diameter and compared between the genders and among the various age groups.Results: The mean age of the subjects was 38.94 ± 17.00 years (range - 14 to 76 years). The average peripapillary RNFL was found to be 102.64 ± 9.56 μm (95 % CI 97.01 - 101.93). The mean ± SD peripapillary RNFL measurements at the superior, nasal, inferior and temporal sectors in the study population were 129.51 ± 15.09 μm, 76.55 ± 12.02 μm, 134.53 ± 17.19 μm and 70.74 ± 15.53 μm respectively. The average RNFL thickness was 99.47 ± 10.18 μm in the male whereas it was 105.09 ± 8.31 μm in the female participants. The RNFL decreased by 2.26 μm per age per decade. Conclusion: The Average RNFL thickness is 102.64 ± 9.56 μm in the Nepalese population. Gender and age related variation in the RNFL could serve as a useful guideline in the diagnosis of glaucoma in our population.DOI: http://dx.doi.org/10.3126/nepjoph.v6i2.11709Nepal J Ophthalmol 2014; 6(12): 131-139

Download Full-text

Re-evaluating diabetic papillopathy using optical coherence tomography and inner retinal sublayer analysis

Eye ◽

10.1038/s41433-021-01664-1 ◽

2021 ◽

Author(s):

Josef Huemer ◽

Hagar Khalid ◽

Daniel Ferraz ◽

Livia Faes ◽

Edward Korot ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Visual Acuity ◽

Optic Disc ◽

Case Series ◽

Retinal Nerve Fibre Layer ◽

Optical Coherence ◽

Patients With Diabetes ◽

Optic Disc Swelling ◽

The Mean

Abstract Background/Objectives To re-evaluate diabetic papillopathy using optical coherence tomography (OCT) for quantitative analysis of the peripapillary retinal nerve fibre layer (pRNFL), macular ganglion cell layer (mGCL) and inner nuclear layer (mINL) thickness. Subjects/Methods In this retrospective observational case series between June 2008 and July 2019 at Moorfields Eye hospital, 24 eyes of 22 patients with diabetes and optic disc swelling with confirmed diagnosis of NAION or diabetic papillopathy by neuro-ophthalmological assessment were included for evaluation of the pRNFL, mGCL and mINL thicknesses after resolution of optic disc swelling. Results The mean age of included patients was 56.5 (standard deviation (SD) ± 14.85) years with a mean follow-up duration of 216 days. Thinning of pRNFL (mean: 66.26, SD ± 31.80 µm) and mGCL (mean volume: 0.27 mm3, SD ± 0.09) were observed in either group during follow-up, the mINL volume showed no thinning with 0.39 ± 0.05 mm3. The mean decrease in visual acuity was 4.13 (SD ± 14.27) ETDRS letters with a strong correlation between mGCL thickness and visual acuity (rho 0.74, p < 0.001). Conclusion After resolution of acute optic disc swelling, atrophy of pRNFL and mGCL became apparent in all cases of diabetic papillopathy and diabetic NAION, with preservation of mINL volumes. Analysis of OCT did not provide a clear diagnostic distinction between both entities. We suggest a diagnostic overlay with the degree of pRNFL and mGCL atrophy of prognostic relevance for poor visual acuity independent of the semantics of terminology.

Download Full-text

Evaluation of Optic Disc Area Using Cirrus HD- Optical Coherence Tomography in Saudi Population

Bioscience Biotechnology Research Communications ◽

10.21786/bbrc/13.4/78 ◽

2020 ◽

Vol 13 (4) ◽

pp. 2152-2156

Author(s):

Nawaf Almarzouki

Keyword(s):

Optical Coherence Tomography ◽

Optic Disc ◽

Optical Coherence ◽

Saudi Population ◽

Disc Area

Download Full-text

Functional Monitoring after Trabeculectomy or XEN Microstent Implantation Using Spectral Domain Optical Coherence Tomography and Visual Field Indices—A Retrospective Comparative Cohort Study

Biology ◽

10.3390/biology10040273 ◽

2021 ◽

Vol 10 (4) ◽

pp. 273

Author(s):

Marc Schargus ◽

Catharina Busch ◽

Matus Rehak ◽

Jie Meng ◽

Manuela Schmidt ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Cohort Study ◽

Visual Field ◽

Spectral Domain ◽

Optical Coherence ◽

Treatment Groups ◽

Rnfl Thickness ◽

Comparative Cohort Study ◽

The Mean ◽

All Treatment

The aim of this study was to compare the efficacy of trabeculectomy (TE), single XEN microstent implantation (solo XEN) or combined XEN implantation and cataract surgery (combined XEN) in primary open-angle glaucoma cases, naïve to prior surgical treatment, using a monocentric retrospective comparative cohort study. Intraocular pressure (IOP) and the number of IOP-lowering drugs (Meds) were monitored during the first 24 months after surgery. Further disease progression was monitored using peripapillary retinal nerve fiber layer (RNFL) thickness examinations using spectral domain optical coherence tomography (OCT) as well as visual acuity (VA) and visual field (VF) tests. In the TE group (52 eyes), the mean IOP decreased from 24.9 ± 5.9 to 13.9 ± 4.2 mmHg (p < 0.001) and Meds decreased from 3.2 ± 1.2 to 0.5 ± 1.1 (p < 0.001). In the solo XEN (38 eyes) and the combined XEN groups, the mean IOP decreased from 24.1 ± 4.7 to 15.7 ± 3.0 mmHg (p < 0.001) and 25.4 ± 5.6 to 14.7 ± 3.2 mmHg (p < 0.001), while Meds decreased from 3.3 ± 0.8 to 0.8 ± 1.2 (p < 0.001) and 2.7 ± 1.2 to 0.4 ± 1.0 (p < 0.001), respectively. The VF and VA indices showed no sign of further deterioration, the RNFL thickness further decreased in all treatment groups after surgery. TE and XEN led to comparable reductions in IOP and Meds. Although the VA and VF indices remained unaltered, the RNFL thickness continuously decreased in all treatment groups during the 24-month follow-up.

Download Full-text

Geographic mapping of choroidal thickness in myopic eyes using 1050-nm spectral domain optical coherence tomography

Journal of Innovative Optical Health Sciences ◽

10.1142/s1793545815500121 ◽

2015 ◽

Vol 08 (04) ◽

pp. 1550012 ◽

Cited By ~ 8

Author(s):

Qinqin Zhang ◽

Maureen Neitz ◽

Jay Neitz ◽

Ruikang K. Wang

Keyword(s):

Optical Coherence Tomography ◽

High Myopia ◽

Choroidal Thickness ◽

Retinal Pigment ◽

Reduction Rate ◽

Radial Distance ◽

Spectral Domain ◽

Temporal Region ◽

Optical Coherence ◽

The Mean

Purpose: To provide a geographical map of choroidal thickness (CT) around the macular region among subjects with low, moderate and high myopia. Methods: 20 myopic subjects (n = 40 eyes) without other identified pathologies participated in this study: 20 eyes of ≤ 3 diopters (D) (low myopic), 10 eyes between -3 and -6D (moderate myopic), and 10 eyes of ≥ 6D (high myopic). The mean age of subjects was 30.2 years (± 7.6 years; range, 24 to 46 years). A 1050 nm spectral-domain optical coherence tomography (SD-OCT) system, operating at 120 kHz imaging rate, was used in this study to simultaneously capture 3D anatomical images of the choroid and measure intraocular length (IOL) in the subject. The 3D OCT images of the choroid were segmented into superior, inferior, nasal and temporal quadrants, from which the CT was measured, representing radial distance between the outer retinal pigment epithelium (RPE) layer and inner scleral border. Measurements were made within concentric regions centered at fovea centralis, extended to 5 mm away from fovea at 1 mm intervals in the nasal and temporal directions. The measured IOL was the distance from the anterior cornea surface to the RPE in alignment along the optical axis of the eye. Statistical analysis was performed to evaluate CT at each geographic region and observe the relationship between CT and the degree of myopia. Results: For low myopic eyes, the IOL was measured at 24.619 ± 0.016 mm. The CT (273.85 ± 49.01 μm) was greatest under fovea as is in the case of healthy eyes. Peripheral to the fovea, the mean CT decreased rapidly along the nasal direction, reaching a minimum of 180.65 ± 58.25μm at 5 mm away from the fovea. There was less of a change in thickness from the fovea in the temporal direction reaching a minimum of 234.25 ± 42.27 μm. In contrast to the low myopic eyes, for moderate and high myopic eyes, CTs were thickest in temporal region (where CT = 194.94 ± 27.28 and 163 ± 34.89 μm, respectively). Like the low myopic eyes, moderate and high myopic eyes had thinnest CTs in the nasal region (where CT = 100.84 ± 16.75 and 86.64 ± 42.6μm, respectively). High myopic eyes had the longest mean IOL (25.983 ± 0.021mm), while the IOL of moderate myopia was 25.413 ± 0.022 mm (**p < 0.001). The CT reduction rate was calculated at 31.28 μm/D (diopter) from low to moderate myopia, whilst it is 13.49 μm/D from moderate to high myopia. The similar tendency was found for the IOL reduction rate in our study: 0.265 mm/D from low to moderate myopia, and 0.137 mm/D from moderate to high myopia. Conclusion: The CT decreases and the IOL increases gradually with the increase of myopic condition. The current results support the theory that choroidal abnormality may play an important role in the pathogenesis of myopic degeneration.

Download Full-text