Long-Term Effects of Postoperative Subconjunctival Injections of Mitomycin-C in the Rabbit Eye

1997 ◽  
Vol 7 (4) ◽  
pp. 340-344 ◽  
Author(s):  
L.E. Pablo ◽  
T. Ramirez ◽  
M. Pueyo ◽  
J.M. Larrosa ◽  
V. Polo ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Subconjunctival Injection ◽  
Long Term Effects ◽  
Rank Tests ◽  
Surgical Sponge ◽  
Operative Evaluation ◽  
Bleb Failure ◽  
Pigmented Rabbits ◽  
Survival Differences

Aim Single or multiple subconjunctival injections of mitomycin-C (MMC) may offer one way of establishing the total dosage of MMC more accurately. The method also allows re-applications later postoperatively. In this experimental, randomized prospective study we compared the effects of a single intraoperative application of MMC at the filtering site and a single postoperative subconjunctival injection of the drug. Methods The left eyes of 32 pigmented rabbits were divided into two groups. In the first group we applied MMC intraoperatively (10) with a 4×1 mm surgical sponge soaked in a MMC solution (0.5 mg/ml). In the second group we injected 0.4 ml of the same solution subconjunctivally (SC) immediately after (conjunctival) suture. Post-operative evaluation was carried out every day during the first week, then every three days until day 58. Survival analyses were done for intraocular pressure (IOP) and bleb failure. Log-rank tests were used to compare survival differences between the groups. Results The IO group showed longer survival parameters than the SC group (p<0.05), both in the control of IOP and as regards blebs. The histological persistence of fistulas was similar. The IO group, however, had a higher incidence of undesirable side effects. Conclusions Our findings suggest IO application of MMC is more effective in reducing fibroblast ingrowth. However, subconjunctival application offers certain advantages such as the possibility of repeating the treatment postoperatively and, therefore, using a smaller initial dose.

Long-term effects of mitomycin C in pterygium surgery on scleral thickness and the conjunctival epithelium

Ophthalmology ◽  
2004 ◽  
Vol 111 (8) ◽  
pp. 1522-1527 ◽  
Author(s):  
Abraham Solomon ◽  
Igor Kaiserman ◽  
Frederick D Raiskup ◽  
David Landau ◽  
Joseph Frucht-Pery
Keyword(s):  
Mitomycin C ◽  
Conjunctival Epithelium ◽  
Long Term Effects ◽  
Pterygium Surgery

Intraoperative and post operative treatment with 5-Fluorouracil and mitomycin-c: long term effects in vivo on subconjunctival and scleral fibroblasts

1992 ◽  
Vol 16 (4-5) ◽  
pp. 381-385 ◽  
Author(s):  
Peng T. Khaw ◽  
Mark B. Sherwood ◽  
J. William Doyle ◽  
M. Fran Smith ◽  
Ian Grierson ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Operative Treatment ◽  
Long Term Effects

Needling after XEN gel implant: What’s the efficacy? A 1-year analysis

2020 ◽  
pp. 112067212096344
Author(s):  
Patrícia José ◽  
Filipa Jorge Teixeira ◽  
Rafael Correia Barão ◽  
Paula Sens ◽  
Luís Abegão Pinto
Keyword(s):  
Mitomycin C ◽  
Predictive Factors ◽  
Primary Outcome ◽  
Salvage Procedure ◽  
Significant Drop ◽  
Safety Parameters ◽  
Single Intervention ◽  
Bleb Failure ◽  
Needle Revision

Purpose: To analyse the long-term efficacy and safety of bleb needling in glaucoma patients previously submitted to XEN implantation. Methods: Retrospective, observational study. Charts from patients who underwent XEN gel implant surgery between October 2015 and December 2017 were reviewed. Needling protocol involves use of Mitomycin C 0.2 mg/mL in an operating room. Primary outcome was defined as intraocular pressure (IOP) lowering efficacy at 12 months post-operative. Complete success was defined as a decrease in IOP > 20% and overall value <18 mmHg. Secondary outcomes included safety parameters (both intra and post-operative). Exploratory analysis of predictive factors for success were performed. Statistical analysis was performed using SPSS version 24. Results: About 94 charts were reviewed, with 18 patients (19%) having undergone needle revision. This salvage procedure was performed after 3.3 ± 3.4 months, achieving a mean IOP reduction of 8.3 ± 8.4 mmHg at 12 months after the procedure (pre-needling: 24.0 ± 5.2 mmHg vs 12th month: 13.5 ± 5.9 mmHg, p < 0.0001). Accordingly, success was achieved in 72% (complete success in 61% of cases). Among predictive factors, there was a higher tendency for success in patients on two types of medications or fewer pre-operatively, cases of standalone XEN surgery and patients with a higher IOP difference pre-needling – day 1. No vision-threatening complications were recorded. Conclusion: XEN salvage procedure with mitomycin C is a valid option in early bleb failure. This single intervention had a long-lasting effect on bleb survival, with almost two-thirds achieving long term significant drop-free IOP reduction.

Long-term effects of mitomycin-C on residual aberration and optical quality after photorefractive keratectomy in eyes with low to moderate myopia

2019 ◽  
Vol 45 (9) ◽  
pp. 1351-1352 ◽  
Author(s):  
Seyed Farzad Mohammadi ◽  
Tahereh Abdolahinia ◽  
Elham Ashrafi ◽  
Somayeh Heydari ◽  
Sepideh Jamali
Keyword(s):  
Mitomycin C ◽  
Optical Quality ◽  
Photorefractive Keratectomy ◽  
Long Term Effects ◽  
Residual Aberration

Long-Term Effects of Simultaneous Subconjunctival and Subscleral Mitomycin C Application in Repeat Trabeculectomy

2002 ◽  
Vol 11 (2) ◽  
pp. 110-118 ◽  
Author(s):  
Yi-an You ◽  
Yang-shun Gu ◽  
Chun-ting Fang ◽  
Xiao-qin Ma
Keyword(s):  
Mitomycin C ◽  
Long Term Effects

Ovarian Dysfunction in Fetally Irradiated Beagles

1977 ◽  
Vol 35 ◽  
pp. 658-659
Author(s):  
T. M. Seed ◽  
M. H. Sanderson ◽  
D. L. Gutzeit ◽  
T. E. Fritz ◽  
D. V. Tolle ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Low Dose ◽  
Long Term Effects ◽  
Ovarian Dysfunction ◽  
Dose Rates ◽  
Highly Sensitive ◽  
Microscopic Evaluation ◽  
Ovarian Pathology ◽  
Normal Offspring

The developing mammalian fetus is thought to be highly sensitive to ionizing radiation. However, dose, dose-rate relationships are not well established, especially the long term effects of protracted, low-dose exposure. A previous report (1) has indicated that bred beagle bitches exposed to daily doses of 5 to 35 R 60Co gamma rays throughout gestation can produce viable, seemingly normal offspring. Puppies irradiated in utero are distinguishable from controls only by their smaller size, dental abnormalities, and, in adulthood, by their inability to bear young.We report here our preliminary microscopic evaluation of ovarian pathology in young pups continuously irradiated throughout gestation at daily (22 h/day) dose rates of either 0.4, 1.0, 2.5, or 5.0 R/day of gamma rays from an attenuated 60Co source. Pups from non-irradiated bitches served as controls. Experimental animals were evaluated clinically and hematologically (control + 5.0 R/day pups) at regular intervals.

Ultrastructural investigations of MDL 19,660-induced effects on the canine platelet and megakaryocyte

1990 ◽  
Vol 48 (3) ◽  
pp. 374-375
Author(s):  
D.E. Loudy ◽  
J. Sprinkle-Cavallo ◽  
J.T. Yarrington ◽  
F.Y. Thompson ◽  
J.P. Gibson
Keyword(s):  
Antidepressant Drug ◽  
Beagle Dogs ◽  
Long Term Effects ◽  
Short Term ◽  
Platelet Counts ◽  
Toxicological Studies ◽  
Induced Aggregation ◽  
Internal Architecture

Previous short term toxicological studies of one to two weeks duration have demonstrated that MDL 19,660 (5-(4-chlorophenyl)-2,4-dihydro-2,4-dimethyl-3Hl, 2,4-triazole-3-thione), an antidepressant drug, causes a dose-related thrombocytopenia in dogs. Platelet counts started to decline after two days of dosing with 30 mg/kg/day and continued to decrease to their lowest levels by 5-7 days. The loss in platelets was primarily of the small discoid subpopulation. In vitro studies have also indicated that MDL 19,660: does not spontaneously aggregate canine platelets and has moderate antiaggregating properties by inhibiting ADP-induced aggregation. The objectives of the present investigation of MDL 19,660 were to evaluate ultrastructurally long term effects on platelet internal architecture and changes in subpopulations of platelets and megakaryocytes.Nine male and nine female beagle dogs were divided equally into three groups and were administered orally 0, 15, or 30 mg/kg/day of MDL 19,660 for three months. Compared to a control platelet range of 353,000- 452,000/μl, a doserelated thrombocytopenia reached a maximum severity of an average of 135,000/μl for the 15 mg/kg/day dogs after two weeks and 81,000/μl for the 30 mg/kg/day dogs after one week.

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