Expression of Metallothionein-I, -II, and -III in Alzheimer Disease and Animal Models of Neuroinflammation

2006 ◽  
Vol 231 (9) ◽  
pp. 1450-1458 ◽  
Author(s):  
Juan Hidalgo ◽  
Milena Penkowa ◽  
Carmen Espejo ◽  
Eva M. Martínez-Cáceres ◽  
Javier Carrasco ◽  
...  
Keyword(s):  
Animal Models ◽  
Alzheimer Disease

Metallothionein-I and -III expression in animal models of Alzheimer disease

Neuroscience ◽  
2006 ◽  
Vol 143 (4) ◽  
pp. 911-922 ◽  
Author(s):  
J. Carrasco ◽  
P. Adlard ◽  
C. Cotman ◽  
A. Quintana ◽  
M. Penkowa ◽  
...  
Keyword(s):  
Animal Models ◽  
Alzheimer Disease

scholarly journals What’s not in the news headlines or titles of Alzheimer disease articles? #InMice

PLoS Biology ◽  
2021 ◽  
Vol 19 (6) ◽  
pp. e3001260
Author(s):  
Marcia Triunfol ◽  
Fabio C. Gouveia
Keyword(s):  
Animal Models ◽  
Alzheimer Disease ◽  
Experimental Studies ◽  
Human Condition ◽  
News Reporting ◽  
News Stories ◽  
Biological Source ◽  
Scientific Papers ◽  
Twitter Account ◽  
News Headlines

There is increasing scrutiny around how science is communicated to the public. For instance, a Twitter account @justsaysinmice (with 70.4K followers in January 2021) was created to call attention to news headlines that omit that mice, not humans, are the ones for whom the study findings apply. This is the case of many headlines reporting on Alzheimer disease (AD) research. AD is characterized by a degeneration of the human brain, loss of cognition, and behavioral changes, for which no treatment is available. Around 200 rodent models have been developed to study AD, even though AD is an exclusively human condition that does not occur naturally in other species and appears impervious to reproduction in artificial animal models, an information not always disclosed. It is not known what prompts writers of news stories to either omit or acknowledge, in the story’s headlines, that the study was done in mice and not in humans. Here, we raised the hypothesis that how science is reported by scientists plays a role on the news reporting. To test this hypothesis, we investigated whether an association exists between articles’ titles and news’ headlines regarding the omission, or not, of mice. To this end, we analyzed a sample of 623 open-access scientific papers indexed in PubMed in 2018 and 2019 that used mice either as models or as the biological source for experimental studies in AD research. We found a significant association (p < 0.01) between articles’ titles and news stories’ headlines, revealing that when authors omit the species in the paper’s title, writers of news stories tend to follow suit. We also found that papers not mentioning mice in their titles are more newsworthy and significantly more tweeted than papers that do. Our study shows that science reporting may affect media reporting and asks for changes in the way we report about findings obtained with animal models used to study human diseases.

Promises of animal models of Alzheimer disease

2004 ◽  
pp. 57-65
Author(s):  
Gérard Emilien ◽  
Cécile Durlach ◽  
Kenneth Lloyd Minaker ◽  
Bengt Winblad ◽  
Serge Gauthier ◽  
...  
Keyword(s):  
Animal Models ◽  
Alzheimer Disease

scholarly journals An Update of Animal Models of Alzheimer Disease with a Reevaluation of Plaque Depositions

2013 ◽  
Vol 22 (2) ◽  
pp. 84-95 ◽  
Author(s):  
Jung-Eun Lee ◽  
Pyung-Lim Han
Keyword(s):  
Animal Models ◽  
Alzheimer Disease

scholarly journals Employing Alzheimer Disease Animal Models for Translational Research: Focus on Dietary Components

2013 ◽  
Vol 13 (2-3) ◽  
pp. 131-134 ◽  
Author(s):  
Cristina Grossi ◽  
Teresa Ed Dami ◽  
Stefania Rigacci ◽  
Massimo Stefani ◽  
Ilaria Luccarini ◽  
...  
Keyword(s):  
Animal Models ◽  
Alzheimer Disease ◽  
Translational Research ◽  
Research Focus ◽  
Dietary Components

scholarly journals Alzheimer disease: Amyloidogenesis, the presenilins and animal models

2007 ◽  
Vol 1772 (3) ◽  
pp. 285-297 ◽  
Author(s):  
M. Newman ◽  
F.I. Musgrave ◽  
M. Lardelli
Keyword(s):  
Animal Models ◽  
Alzheimer Disease
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