The Department of Homeland Security (DHS) formally incorporated Human Systems Integration (HSI) in systems and policy development in 2012. Since then, DHS components have been establishing HSI capabilities to meet their unique human needs. This discussion panel will focus on the operational transformation and governance strategy for implementing a successful human systems integration (HSI) program across components within the Department of Homeland Security (DHS). Members of the Transportation Security Administration (TSA), United States Coast Guard (USCG), and Department of Homeland Security Science and Technology Directorate (DHS S&T) will discuss the challenges faced when advocating for HSI, and the best practices developed to better integrate research activities with systems engineering.