Prospective Study on Sexual Dysfunction in Male Chinese Liver Transplant Recipients

In patients with end-stage liver disease, hypogonadism and erectile dysfunction are often seen. This study was to determine the incidence of erectile dysfunction before and after liver transplantation (LT) with correlation to change in sex hormone levels from a Chinese cohort. This prospective longitudinal study was registered with The University of Hong Kong Clinical Trials Centre (HKUCTR-1563). The Institutional Review Board approval number is UW-12-273. The study period was from January 2012 to December 2016. Adult male patients with end-stage liver disease enlisted for LT were recruited on informed written consent. All recruited patients were to complete a cross-sectional cohort questionnaire—International Index of Erectile Function, version 5 (IIEF5)—and to receive serum sex hormone checks before and after LT. Twenty-eight patients who underwent LT were included in the analysis. The included patients had significantly reduced prolactin ( p < .001) and 17-beta-estradiol ( p = .024) after LT. There was also a significant drop of IIEF5 score at 1 month after LT, but the score returned to pre-LT level at 6 months. This study demonstrated that there was improvement in sex hormone levels after LT, namely, normalization of estradiol level and lowering of prolactin and progesterone levels. However, improvement in sex hormone levels did not translate into improvement of erectile dysfunction.

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Erectile Dysfunction in End-Stage Liver Disease Men

Journal of Sexual Medicine ◽

10.1111/j.1743-6109.2008.01169.x ◽

2009 ◽

Vol 6 (5) ◽

pp. 1395-1401 ◽

Cited By ~ 21

Author(s):

Eric Huyghe ◽

Nassim Kamar ◽

Fabien Wagner ◽

Aude-Hélène Capietto ◽

Labib El-Kahwaji ◽

...

Keyword(s):

Erectile Dysfunction ◽

Liver Disease ◽

End Stage Liver Disease ◽

End Stage

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Implications of Nonalcoholic Steatohepatitis as the Cause of End-Stage Liver Disease Before and After Liver Transplant

Gastroenterology Clinics of North America ◽

10.1016/j.gtc.2019.09.005 ◽

2020 ◽

Vol 49 (1) ◽

pp. 165-178

Author(s):

Anchalia Chandrakumaran ◽

Mohammad Shadab Siddiqui

Keyword(s):

Liver Disease ◽

Liver Transplant ◽

Nonalcoholic Steatohepatitis ◽

End Stage Liver Disease ◽

Before And After ◽

End Stage

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TESTOSTERONE CHANGES IN PATIENTS WITH LIVER CIRRHOSIS BEFORE AND AFTER ORTHOTOPIC LIVER TRANSPLANTATION AND ITS CORRELATION WITH MELD

Arquivos de Gastroenterologia ◽

10.1590/s0004-28032014000100012 ◽

2014 ◽

Vol 51 (1) ◽

pp. 59-63 ◽

Cited By ~ 13

Author(s):

Rodrigo NITSCHE ◽

Júlio Cezar Uili COELHO ◽

Alexandre Coutinho Teixeira de FREITAS ◽

Clementino ZENI NETO ◽

Eduardo MARTINS

Keyword(s):

Liver Transplantation ◽

Liver Disease ◽

Orthotopic Liver Transplantation ◽

Free Testosterone ◽

Serum Levels ◽

Sex Hormone ◽

Sex Hormone Binding Globulin ◽

Hormone Binding ◽

End Stage Liver Disease ◽

End Stage

Context Hypogonadism is a common clinical situation in male patients with liver cirrhosis. Objectives The aim of the present study was to evaluate the effects of orthotopic liver transplantation on testosterone, free testosterone and sex hormone-binding globulin in male with advanced liver disease and also to determine the relationship of these changes with Model for End-stage Liver Disease (MELD) score. Methods In a prospective study, serum levels of testosterone, free testosterone and sex hormone-binding globulin of 30 male adult patients with end-stage liver disease were measured 2 to 4 hours before and 6 months after orthotopic liver transplantation. Results Total testosterone levels increased after orthotopic liver transplantation and the number of patients with normal testosterone levels increased from 18 to 24. Free testosterone mean level in the pre-transplant group was 7.8 pg/mL and increased to 11.5 pg/mL (P = 0.10) and sex hormone-binding globulin level decreased after orthotopic liver transplantation returning to normal levels in MELD ≤18 - group (A) (P<0.05). Conclusions Serum level changes of testosterone, free testosterone and sex hormone-binding globulin are more pronounced in cirrhotic males with MELD ≤18. Serum levels of testosterone and free testosterone increase and serum levels of sex hormone-binding globulin decrease after orthotopic liver transplantation.

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