Two case reports of generalized pustular psoriasis of pregnancy: Different outcomes

Generalized pustular psoriasis of pregnancy is a rare dermatosis with potential serious consequences for both the mother and fetus. Treatment is difficult and historically steroids were the mainstay of treatment. Cyclosporin has been used for a few cases resistant to steroids. We report our own experience of two cases of generalized pustular psoriasis of pregnancy. Cases of generalized pustular psoriasis of pregnancy need review by a dermatologist with experience of skin disorders in pregnancy. Both the fetus and mother need to be monitored closely when systemic illness occurs, as there is a risk of stillbirth. Maternal sepsis is a known complication of generalized pustular psoriasis of pregnancy. Cyclosporin, when used appropriately is effective and relatively safe.

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An Examination of Generalized Pustular Psoriasis in Pregnancy Based on the Serum Cytokine Levels.

Nishi Nihon Hifuka ◽

10.2336/nishinihonhifu.61.144 ◽

1999 ◽

Vol 61 (2) ◽

pp. 144-147

Author(s):

Miyako KUDO ◽

Yoshihiro UMEBAYASHI ◽

Tomoe KOTSUJI ◽

Fujio OTSUKA

Keyword(s):

Pustular Psoriasis ◽

Serum Cytokine ◽

Cytokine Levels ◽

Generalized Pustular Psoriasis ◽

In Pregnancy

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Long-Term Management of Generalized Pustular Psoriasis with Infliximab: Case Series

Journal of Cutaneous Medicine and Surgery ◽

10.2310/7750.2008.07036 ◽

2008 ◽

Vol 12 (4) ◽

pp. 184-188 ◽

Cited By ~ 7

Author(s):

Shannon B. Routhouska ◽

Pranav B. Sheth ◽

Neil J. Korman

Keyword(s):

Case Reports ◽

Case Series ◽

Term Treatment ◽

Pustular Psoriasis ◽

Short Term Treatment ◽

Long Term Treatment ◽

Generalized Pustular Psoriasis ◽

Factor Α ◽

Term Management

Background: Infliximab, a tumor necrosis factor α antagonist, has recently been shown to be successful for the short-term treatment of generalized pustular psoriasis (GPP) in multiple case reports. Objective: The goal of this case series was to assess the efficacy of the longer-term management of GPP with infliximab. Methods: Three patients with severe GPP were followed to assess the efficacy of long-term treatment with infliximab. Results: Infliximab therapy was more efficacious with infusion every 6 to 8 weeks in combination with methotrexate. Conclusion: Infliximab may be efficacious for some patients for the long-term management of GPP. Maintaining a strict infliximab infusion schedule and concomitant methotrexate therapy may decrease infusion reactions and increase efficacy.

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Generalized pustular psoriasis in pregnancy, successfully treated with certolizumab pegol

The Journal of Dermatology ◽

10.1111/1346-8138.15355 ◽

2020 ◽

Vol 47 (7) ◽

Author(s):

Yoko Mizutani ◽

Yuki H. Mizutani ◽

Kanako Matsuyama ◽

Miho Kawamura ◽

Asami Fujii ◽

...

Keyword(s):

Certolizumab Pegol ◽

Pustular Psoriasis ◽

Generalized Pustular Psoriasis ◽

In Pregnancy

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Personal treatment experience for severe generalized pustular psoriasis of pregnancy: two case reports

Dermatologic Therapy ◽

10.1111/dth.12112 ◽

2013 ◽

Vol 27 (3) ◽

pp. 174-177 ◽

Cited By ~ 7

Author(s):

Li Luan ◽

Shixin Han ◽

Zhenying Zhang ◽

Xiaoming Liu

Keyword(s):

Case Reports ◽

Pustular Psoriasis ◽

Treatment Experience ◽

Generalized Pustular Psoriasis

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Widespread Erythematous Plaques in a Multigravid Female

SKIN The Journal of Cutaneous Medicine ◽

10.25251/skin.3.1.7 ◽

2019 ◽

Vol 3 (1) ◽

Author(s):

Alex Harrison ◽

George Gibbons, MD ◽

Joseph Dyer, DO

Keyword(s):

Pustular Psoriasis ◽

Histopathological Analysis ◽

Unborn Child ◽

Fetal Outcomes ◽

Diagnostic Uncertainty ◽

Generalized Pustular Psoriasis ◽

Erythematous Plaques ◽

In Pregnancy

When dermatological eruptions present diagnostic uncertainty, there is cause for concern, especially when treating the mother of an unborn child. While cutaneous outbreaks in pregnancy can be benign, suspicious disseminating rashes should warrant further investigation. We present a case of generalized pustular psoriasis of pregnancy that manifested in an atypical fashion and could have been overlooked without the utilization of biopsy and histopathological analysis. Due to reports of unfavorable maternal-fetal outcomes, prompt evaluation and treatment is critical.

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