scholarly journals Description of a Novel Patch Pump for Insulin Delivery and Comparative Accuracy Evaluation

2021 ◽  
pp. 193229682110004
Author(s):  
Annette Baumstark ◽  
Jochen Mende ◽  
Joji Uchiyama ◽  
Cornelia Haug ◽  
Guido Freckmann
Keyword(s):  
Continuous Subcutaneous Insulin Infusion ◽  
Insulin Infusion ◽  
Insulin Delivery ◽  
Accuracy Evaluation ◽  
Subcutaneous Insulin ◽  
Stepping Motor ◽  
Basal Rate ◽  
Comparative Accuracy

A new insulin patch pump for continuous subcutaneous insulin infusion was developed. The pump is composed of reusable and disposable parts and operates with a stepping motor. This pump was compared to a patch pump and a durable pump regarding basal rate and bolus accuracy. Using a microgravimetric method, boluses of 0.2 U, 1 U and 7 U, and a basal rate of 1 U/h were tested. For all pumps, bolus accuracy was higher when larger volumes were delivered. While median deviations were similar for all pumps, there were differences in the precision of individual boluses and when regarding basal rate delivery divided into 1-h windows.

Experimental and Theoretical Studies of Pulsed Micro Flows Pertinent to Continuous Subcutaneous Insulin Infusion (CSII) Therapy

2010 ◽  
Author(s):  
Bin Wang ◽  
Hui Hu ◽  
Ayodeji Demuren ◽  
Eric Gyurcsko
Keyword(s):  
Continuous Subcutaneous Insulin Infusion ◽  
Insulin Infusion ◽  
Insulin Pump ◽  
Insulin Delivery ◽  
Transient Behavior ◽  
Creeping Flow ◽  
Insulin Pump Therapy ◽  
Subcutaneous Insulin ◽  
Micro Piv ◽  
Micro Flows

Continuous subcutaneous insulin infusion (CSII) therapy, also known as insulin pump therapy, has become an important advancement in diabetes therapy to improve the quality of life for millions of diabetes patients. Insulin delivery failures caused by the precipitations of insulin within micro-sized CSII tubing systems have been reported in recent years. It has also been conjectured that the flow of insulin through an insulin infusion set may be reduced or inhibited by air bubbles entrained into the capillary CSII tubing system during the typical three- to five-day operation between refills. Currently, most solutions to insulin occlusion related problems are based on clinical trials. In the present study, an experimental and theoretic study was conducted to investigate the pulsed flows inside the micro-sized CSII tubing system. A micro-PIV system was used to provide detailed flow velocity field measurements inside the capillary CSII tubing system to characterize the transient behavior of the micro-flows upon the pulsed actuation of the insulin pump used in CSII therapy. It was found that the microflow inside the CSII tubing system is highly unsteady, which is much more interesting than the creeping flow that the nominal averaged flow rates would suggest. A theoretic frame work was also performed to model the pulsed micro-flows driven by the insulin pump to predict the transient behavior of the microflows and velocity distributions inside the micro-sized CSII tubing system. The measurement results and the theoretic predictions were compared quantitatively to elucidate underlying physics for a better understanding of the microphysical process associated with the insulin delivery in order to provide a better guidance for troubleshooting of insulin occlusion in CSII therapy.

scholarly journals Continuous Subcutaneous Insulin Infusion and Its Characteristics in Young People with Type 1 Diabetes with Optimal Glucose Control (Preprint)

2018 ◽  
Author(s):  
Goran Petrovski ◽  
Marija Zivkovic
Keyword(s):  
Type 1 Diabetes ◽  
Young People ◽  
Glucose Control ◽  
Continuous Subcutaneous Insulin Infusion ◽  
Insulin Infusion ◽  
Early Morning ◽  
Fine Tuning ◽  
Subcutaneous Insulin ◽  
Basal Rate

BACKGROUND Continuous subcutaneous insulin infusion (CSII) is established model for mimicking physiological insulin, which can overcome some of these barriers. CSII therapy is becoming more popular treatment modality in young people with T1D.Several studies have demonstrated the superiority of CSII over MDI therapy in T1D patients in terms of improved glucose control, the rate of hypoglycemia, dawn phenomenon and glucose variability OBJECTIVE To describe Continuous Subcutaneous Insulin Infusion (CSII) characteristics in young people with Type 1 Diabetes (T1D) with optimal glucose control and to describe possible simple CSII settings for fine tuning. METHODS This retrospective study was conducted at University Clinic of Endocrinology, Diabetes and Metabolic Disorders in Skopje. The study enrolled CSII patients with T1D (age 12-25 years) visited our center from January to December 2016. Patient characteristics were collected through the electronic medical record system and CSII characteristics were obtained from 8 weeks reports prior to Hba1c, generated by Carelink Therapy Management Software (Medtronic, Northridge, USA). RESULTS Ninety-three patients were grouped according age: 12-18 years and 19-25 years. More than 70% of patients achieved HbA1c <7.5% (<58 mmol/mol). Significant difference in basal insulin was found between two age groups. Patients aged 12-18 years had five basal segments, less basal rate in early morning (03-07h) and slight decrease of afternoon basal rate (13-19h), comparing with patients aged 19-25 years with four basal segments, more basal rate in early morning (03-07h) and no decrease of afternoon basal rate (13-19h). CONCLUSIONS Optimal glucose control is achievable in real life conditions among T1D patients on CSII therapy. Bolus wizard, frequent bolusing, multiple basal segments, and close follow up can be determinants for better control. Simple CSII settings as a tool, derived from our data may help clinicians to fine tune T1D patients and achieve optimal glucose control. CLINICALTRIAL EN16-12

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