scholarly journals Effectiveness and safety of daptomycin in patients with infective endocarditis undergoing heart valve replacement: a subgroup analysis from real-world data

2017 ◽  
Vol 4 (2) ◽  
pp. 41-47 ◽  
Author(s):  
Achyut Guleri ◽  
Riccardo Utili ◽  
Pascal Dohmen ◽  
Kamal Hamed
Keyword(s):  
Infective Endocarditis ◽  
Success Rate ◽  
Clinical Outcomes ◽  
Valve Replacement ◽  
Heart Valve ◽  
Real World ◽  
Clinical Success ◽  
Clinical Success Rate ◽  
Heart Valve Replacement ◽  
Real World Data

Background: European Cubicin® Outcomes Registry and Experience (EU-CORE) was a retrospective, non-interventional, multicenter registry that collected real-world clinical outcomes following daptomycin use for the treatment of Gram-positive infections. EU-CORE data from patients with infective endocarditis (IE) who underwent heart valve replacement were analysed. Methods: Clinical outcomes were assessed as success (cured or improved), failure, or non-evaluable. Adverse events (AEs) were recorded for up to 30 days after daptomycin treatment. Results: Of 610 patients with IE, 198 [32.5%; left-sided IE (LIE), 166 (83.8%); right-sided IE (RIE), 21 (10.6%); both LIE and RIE, 11 (5.6%)] underwent heart valve replacement. Other than cardiovascular disease, renal disease (18.2%), sepsis (16.2%), and diabetes mellitus (15.2%) were the most significant underlying diseases. Major pathogens in patients with positive culture results (68.0%) were Staphylococcus aureus [36.8%; methicillin-resistant S. aureus (MRSA), 12.8%] and coagulase-negative staphylococci (CoNS; 31.6%). Daptomycin treatment [median duration (range), 21 days (1–112)] resulted in high clinical success in patients with S. aureus (88.4%; MRSA, 80.0%) and CoNS (81.1%) infections, with an overall success rate of 83.3%. Clinical success rate was high (90.0%) in patients who received daptomycin dose >6 mg/kg/day. Overall clinical success rate in patients followed for up to 2 years was 90.7%. AEs and serious AEs possibly related to daptomycin were reported in 6 (3.0%) and 4 (2.0%) patients, respectively. Conclusions: Daptomycin treatment was effective and well tolerated with a sustained response in patients with IE who underwent heart valve surgery. A trend towards better clinical outcomes was observed with higher daptomycin doses.

scholarly journals Self-Management in Patients with Heart Valve Replacement and Its Clinical Outcomes: A Systematic Review

2020 ◽  
Author(s):  
Shirdel Zandi ◽  
Behzad Imani ◽  
Salman khazaei ◽  
GHolamreza Safarpor
Keyword(s):  
Systematic Review ◽  
Clinical Outcomes ◽  
Valve Replacement ◽  
Heart Valve ◽  
Low Dose ◽  
Anticoagulation Therapy ◽  
Heart Valve Replacement ◽  
Self Management ◽  
Screening Process ◽  
Valve Function

Abstract Background: For patients with heart valve replacement, self-management can play an important role in controlling the patient's condition, therefore, the purpose of this review was to identify the aspects of self-management and its clinical outcomes in patients with heart valve replacement. Methods: We conducted a systematic review of peer-reviewed research literature focused on self-management in patients with heart valve replacement. The databases of PubMed, Scopus, and web of science were searched until May 2020 free from time and language limitation. Al documents were assessed for eligible articles by title or abstract according to the search strategy.The screening process of articles was conducted by two independent authors. The selected articles were checked regarding to inclusion and exclusion criteria.Results: Finally, 25 studies were considered in this systematic review. Self-management of these patients has prerequisites and requires appropriate training. Self-management in these patients is applicable in the aspects of Anticoagulation therapy self-management, INR self-testing, Low-dose INR Self-management, and Heart valve function self-monitoring. In this method, with better control of INR levels and Anticoagulation therapy, the incidence of complications will be reduced and patients will be able to diagnose functional disorders in the early stages by monitoring the function of valve, which will prevent the progression of complications. Conclusion: The results of this review clearing that self-management is applicable in the aspects of Anticoagulation therapy, INR control, low dose INR management, and monitoring of cardiac valve function and by improving care standards, it will improve the quality of treatment for these patients.

scholarly journals Incidence and factors associated with infective endocarditis in patients undergoing left-sided heart valve replacement

2018 ◽  
Vol 39 (28) ◽  
pp. 2668-2675 ◽  
Author(s):  
Lauge Østergaard ◽  
Nana Valeur ◽  
Nikolaj Ihlemann ◽  
Morten Holdgaard Smerup ◽  
Henning Bundgaard ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Valve Replacement ◽  
Heart Valve ◽  
Heart Valve Replacement ◽  
Factors Associated

Impact of peritoneal carcinomatosis on clinical outcomes of patients receiving self-expandable metal stents for malignant colorectal obstruction

Endoscopy ◽  
2018 ◽  
Vol 50 (12) ◽  
pp. 1163-1174 ◽  
Author(s):  
Jae Park ◽  
Kwangwon Rhee ◽  
Jin Yoon ◽  
Soo Park ◽  
Joo Kim ◽  
...  
Keyword(s):  
Peritoneal Carcinomatosis ◽  
Success Rate ◽  
Clinical Outcomes ◽  
Clinical Success ◽  
Clinical Success Rate ◽  
Metal Stents ◽  
Independent Factor ◽  
Success Rates ◽  
Colorectal Obstruction ◽  
Technical Success Rate

Abstract Background Peritoneal carcinomatosis can influence clinical outcomes of patients receiving self-expandable metal stents (SEMS) for malignant colorectal obstruction, but data regarding this issue are sparse. We analyzed the clinical outcomes of post-SEMS insertion for malignant colorectal obstruction based on carcinomatosis status. Methods Stent- and patient-related clinical outcomes were compared for carcinomatosis status in a retrospective review involving 323 consecutive patients (colorectal cancer 198 patients; extracolonic malignancy 125 patients) who underwent palliative SEMS placement for malignant colorectal obstruction from January 2005 to March 2012. Severity of carcinomatosis was classified as mild, moderate, or severe. Results Carcinomatosis was observed in 190 patients (58.8 %). The rates of technical (84.7 vs. 94.7 %; P = 0.005) and clinical (73.2 vs. 83.5 %; P = 0.03) success were lower in patients with vs. without carcinomatosis. Rates of early (2.1 % vs. 3.0 %; P = 0.72) and delayed (1.6 % vs. 6.0 %; P = 0.08) perforation and stent failure (27.9 % vs. 26.3 %; P = 0.75) showed no difference. Technical and clinical success rates were significantly different based on the severity of carcinomatosis (technical success rate: mild 90.7 %, moderate 97.4 %, severe 76.3 %, P = 0.003; clinical success rate: mild 83.3 %, moderate 82.1 %, severe 63.9 %, P = 0.01). In multivariate analysis, severe carcinomatosis was identified as an independent factor related to technical (odds ratio [OR] 0.18, 95 % confidence interval [CI] 0.06 – 0.56) and clinical (OR 0.33, 95 %CI 0.15 – 0.74) success. Conclusions Peritoneal carcinomatosis was associated with decreased technical and clinical success rates in patients receiving SEMS for malignant colorectal obstruction. Moreover, the presence of severe carcinomatosis was an independent factor determining these clinical outcomes.

Biological heart valve replacement after heart transplantation

2005 ◽  
Vol 53 (S 3) ◽  
Author(s):  
D Gürsoy ◽  
U Schulz ◽  
G Tenderich ◽  
J Jahanyar ◽  
A Maleszka ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Valve Replacement ◽  
Heart Valve ◽  
Heart Valve Replacement

Long-term anticoagulation self-testing after mechanical heart valve replacement

2007 ◽  
Vol 55 (S 1) ◽  
Author(s):  
H Mair ◽  
B Reichart ◽  
I Kaczmarek ◽  
G Juchem ◽  
P Überfuhr ◽  
...  
Keyword(s):  
Valve Replacement ◽  
Heart Valve ◽  
Mechanical Heart Valve ◽  
Heart Valve Replacement ◽  
Self Testing
Sign in / Sign up

Export Citation Format

Share Document