scholarly journals A rare case of a non-neural granular cell tumor presenting as an enlarging right chest wall nodule in a 4-year-old male and review of the literature

2020 ◽  
Vol 8 ◽  
pp. 2050313X2093824
Author(s):  
Ali Shahabi ◽  
Hope Hastings ◽  
Harry Winfield ◽  
Amer Khiyami
Keyword(s):  
Chest Wall ◽  
Granular Cell Tumor ◽  
Immunohistochemical Analysis ◽  
Granular Cell ◽  
Cell Tumor ◽  
Cell Of Origin ◽  
Nerve Sheath ◽  
Granular Eosinophilic Cytoplasm ◽  
Eosinophilic Cytoplasm ◽  
Pathologic Analysis

Non-neural granular cell tumor was first described in 1991 as an unusual primitive, polypoid variant of the conventional granular cell tumor. To date, this neoplasm remains a rare entity and the cell of origin is uncertain. While the histological features are similar to the conventional granular cell tumor, it represents a distinct entity that is negative for S100 and lacks true nerve sheath differentiation. Here, we describe a case of a 4-year-old male who presented with a painless, soft nodule on his right chest wall that was slowly increasing in size. The mass was excised and sent for pathologic analysis. Microscopic examination reveals spindle and epithelioid cells with vesicular nuclei and prominent granular eosinophilic cytoplasm. Immunohistochemical analysis shows negative staining for S100 and AE1/AE3/PCK26 but is positive for CD68. A diagnosis of a non-neural granular cell tumor was made. We report a rare and diagnostically challenging case in a pediatric patient.

scholarly journals Granular Cell Tumor of Breast: Rare Tumor Masquerading as Malignancy

2020 ◽  
Vol 42 (1) ◽  
pp. 62-64
Author(s):  
Suzita Hirachan ◽  
Yogendra P Singh ◽  
Anamika Jha ◽  
Usha Manandhar
Keyword(s):  
Granular Cell Tumor ◽  
Periodic Acid ◽  
Granular Cell ◽  
Cell Tumor ◽  
Periodic Acid Schiff ◽  
Granular Eosinophilic Cytoplasm ◽  
Eosinophilic Cytoplasm ◽  
S 100 ◽  
Proper Diagnosis ◽  
The Right

Granular cell tumor (GCT) is a rare soft tissue tumor that arises from the Schwann cells of peripheral nerves. It was first postulated by Abrikossoff in 1926 as Myoblastoma. About 5-15% of these tumors occur in the breast and less than 1% has the potential to be malignant. Here we present a case of 41 years old premenopausal woman with Benign GCT of the right breast, having clinically malignant features. The clinical and radiological features of GCT are similar to malignant lump. However, histology showing presence of sheets of polygonal cells with abundant granular eosinophilic cytoplasm with round nuclei and granules with Periodic acid–Schiff (PAS) positive, diastase resistant and S-100 antigen positive are confirmatory. Treatment of Granular cell tumor is wide local excision. There is apparently no role of chemotherapy and radiotherapy. The presence of GCT in the breast is quite rare and clinically as well as radiologically it may mimic malignancy, however with histopathology and appropriate immunohistochemistry, proper diagnosis can be made.

scholarly journals Granular Cell Tumor Occurring in the Chest Wall: A Case Report

2012 ◽  
Vol 45 (3) ◽  
pp. 196-198 ◽  
Author(s):  
Ji Young Park ◽  
Jae Joon Hwang ◽  
Song Am Lee ◽  
Woo Surng Lee ◽  
Yo Han Kim ◽  
...  
Keyword(s):  
Case Report ◽  
Chest Wall ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor

An unusual breast lesion: Granular cell tumor of the breast with extensive chest wall invasion

2014 ◽  
Vol 110 (3) ◽  
pp. 345-347 ◽  
Author(s):  
Sarah J. Coates ◽  
Katrina Mitchell ◽  
Olushola B. Olorunnipa ◽  
Robert A. DeSimone ◽  
David M. Otterburn ◽  
...  
Keyword(s):  
Chest Wall ◽  
Breast Lesion ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor ◽  
Chest Wall Invasion ◽  
Wall Invasion

scholarly journals Granular cell tumor that originated in a posterior ethmoid sinus

2017 ◽  
Vol 3 (3) ◽  
pp. 721
Author(s):  
Myung Woo Kim ◽  
Sun Hee Chang ◽  
Ick Soo Choi
Keyword(s):  
Nasal Cavity ◽  
Nasal Polyp ◽  
Granular Cell Tumor ◽  
Neuron Specific Enolase ◽  
Granular Cell ◽  
Ethmoid Sinus ◽  
Cell Tumor ◽  
The Body ◽  
Eosinophilic Cytoplasm ◽  
The Right

<p class="abstract"><span lang="EN-US">A granular cell tumor (GCT) is a rare neoplasm. It grows slowly, presumably originates from a Schwann cell, and is typically benign. Histopathologically, GCTs are composed of loosely infiltrating sheets of large, pale, polyhedral cells with abundant granular eosinophilic cytoplasm and a pale, centrally situated nucleus. Immunohistochemically, GCTs express the S-100 protein and neuron-specific enolase. A GCT can occur anywhere in the body. Half of all GCTs occur in the head and neck regions, especially on the tongue, but they are rarely found in the nasal cavity. A GCT usually arises as a solitary tumor and can be confirmed only by a histologic examination. The appropriate treatment is excision of the lesion. </span>Here, we present a rare case of a GCT originating in the right posterior ethmoid sinus in the nasal cavity. A GCT originating in a posterior ethmoid sinus has not been reported thus far. In our case, a simple nasal polyp was found in the left ethmoid sinus of the patient. Thus, we initially misjudged the GCT in the right nasal cavity as a simple nasal polyp.</p>

scholarly journals Granular cell tumor of the chest wall.

2000 ◽  
Vol 14 (5) ◽  
pp. 627-630
Author(s):  
Yasuyuki Shibata ◽  
Hiroshi Niwa ◽  
Takeshi Yamada ◽  
Hisanori Kani ◽  
Katsutoshi Maemoto ◽  
...  
Keyword(s):  
Chest Wall ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor

scholarly journals A case of malignant granular cell tumor in the chest wall

2012 ◽  
Vol 73 (3) ◽  
pp. 557-562
Author(s):  
Atsushi IMAI ◽  
Tadahiro OSADA ◽  
Tokushi KOBAYASHI ◽  
Makoto NISHIKAWA ◽  
Hiroko GOTOHDA
Keyword(s):  
Chest Wall ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor ◽  
Malignant Granular Cell Tumor

Granular Cell Tumor of the Chest Wall

Authorea ◽  
2020 ◽  
Author(s):  
Dov Levine ◽  
Hirohisa Ikegami ◽  
Mark Russo ◽  
Leonard Lee ◽  
Anthony Lemaire
Keyword(s):  
Chest Wall ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor

Malignant granular cell tumor of the chest wall

Skin Cancer ◽  
2017 ◽  
Vol 32 (1) ◽  
pp. 61-65
Author(s):  
Kazumasa OYA ◽  
Shijima TAGUCHI ◽  
Takahiro HOSOI ◽  
Yoko MARUYAMA ◽  
Yoshio NAKAYAMA
Keyword(s):  
Chest Wall ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor ◽  
Malignant Granular Cell Tumor

scholarly journals Morphological spectrum of peripheral nerve sheath tumors: An insight into World Health Organization 2013 classification

2016 ◽  
Vol 07 (03) ◽  
pp. 346-354 ◽  
Author(s):  
Panduranga Chikkannaiah ◽  
Mythri M. Boovalli ◽  
Velusamy Nathiyal ◽  
Srinivasamurthy Venkataramappa
Keyword(s):  
Peripheral Nerve ◽  
Granular Cell Tumor ◽  
Malignant Tumors ◽  
Granular Cell ◽  
Cell Tumor ◽  
World Health ◽  
Nerve Sheath Tumors ◽  
Peripheral Nerve Sheath Tumors ◽  
Nerve Sheath ◽  
Health Organization

ABSTRACT Introduction: Peripheral nerve sheath tumors (PNSTs) are neuroectodermal in origin. Now these tumors are classified under World Health Organization (WHO) classification of tumors of soft tissue and bone 2013. Objective: To study the morphological spectrum of PNST and to study the secondary degenerative changes associated with it. Materials and Methods: This study was conducted from January 2010 to June 2015. The gross details of tumor and patient's demographic profiles were reviewed. The hematoxylin and eosin stained slides were reassessed and the lesions were categorized and classified as per the WHO 2013 classification. The tumors were also assessed for secondary degenerative changes. Results: Our study comprised 143 cases of PNST. Age of the patients ranged from 5 to 75 years. 21–30 years is the most common age of occurrence with head and neck being the most common site. The PNSTs observed in the present study were neurofibroma (NF) (61.5%), schwannoma (36%), malignant PNST (2%), and granular cell tumor (0.5%). Nearly 10% of NF fulfilled the criteria for neurofibromatosis 1 (NF1). Rare tumors such as plexiform schwannoma and granular cell tumor were also observed. Malignant tumors were larger in dimension than benign. Myxoid, cystic, and hyaline changes were commonly associated with benign tumors while necrosis, hemorrhage, and mitotic activity were seen with malignant tumors. Conclusion: This series highlights the pathological variants of PNST along with their morphological changes and NF1 association. It is essential to be familiar with all these variants of PNST for accurate diagnosis as they have varied biological behavior.

scholarly journals Rare case of granular cell tumor of perianal region: a case report and literature review

2021 ◽  
Vol 49 (1) ◽  
pp. 030006052098268
Author(s):  
Jianhua Ma ◽  
Yicheng Cheng ◽  
Xue Li ◽  
Wei Liu ◽  
Renghai Liu ◽  
...  
Keyword(s):  
Granular Cell Tumor ◽  
Immunohistochemical Analysis ◽  
Granular Cell ◽  
Cell Tumor ◽  
Accurate Diagnosis ◽  
Perianal Region ◽  
Appropriate Treatment ◽  
Anal Neoplasm ◽  
Clinical Complaint

Granular cell tumors (GCTs) are rare submucosal neoplasms, with tumors in the oral mucosa accounting for about a third of all cases. In contrast, GCT is a rare anal neoplasm, with fewer than 30 cases of perianal GCT reported in the literature. We report the case of a 36-year-old woman with a perianal lump with no obvious local lesion as the main clinical complaint. The tumor was completely resected and histologically confirmed as a GCT. The patient remained under continuous follow-up. GCT is difficult for surgeons and pathologists to diagnose, and biopsy and immunohistochemical analysis are prerequisites for an accurate diagnosis. An integrated understanding of GCT in terms of its differential diagnosis will contribute to better identification and more appropriate treatment of this disease.

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