scholarly journals Granular cell tumor that originated in a posterior ethmoid sinus

2017 ◽  
Vol 3 (3) ◽  
pp. 721
Author(s):  
Myung Woo Kim ◽  
Sun Hee Chang ◽  
Ick Soo Choi
Keyword(s):  
Nasal Cavity ◽  
Nasal Polyp ◽  
Granular Cell Tumor ◽  
Neuron Specific Enolase ◽  
Granular Cell ◽  
Ethmoid Sinus ◽  
Cell Tumor ◽  
The Body ◽  
Eosinophilic Cytoplasm ◽  
The Right

<p class="abstract"><span lang="EN-US">A granular cell tumor (GCT) is a rare neoplasm. It grows slowly, presumably originates from a Schwann cell, and is typically benign. Histopathologically, GCTs are composed of loosely infiltrating sheets of large, pale, polyhedral cells with abundant granular eosinophilic cytoplasm and a pale, centrally situated nucleus. Immunohistochemically, GCTs express the S-100 protein and neuron-specific enolase. A GCT can occur anywhere in the body. Half of all GCTs occur in the head and neck regions, especially on the tongue, but they are rarely found in the nasal cavity. A GCT usually arises as a solitary tumor and can be confirmed only by a histologic examination. The appropriate treatment is excision of the lesion. </span>Here, we present a rare case of a GCT originating in the right posterior ethmoid sinus in the nasal cavity. A GCT originating in a posterior ethmoid sinus has not been reported thus far. In our case, a simple nasal polyp was found in the left ethmoid sinus of the patient. Thus, we initially misjudged the GCT in the right nasal cavity as a simple nasal polyp.</p>

scholarly journals Granular cell tumor of the breast: Case report

Mastology ◽  
2020 ◽  
Vol 30 (Suppl 1) ◽  
Author(s):  
Juliana da Costa Souza ◽  
Juliana Ferreira de Lima ◽  
Aline Bortolotto Di Pace ◽  
Sandro Luiz Sayão Prior ◽  
Luiz Henrique Gebrim
Keyword(s):  
Case Report ◽  
Black Women ◽  
Granular Cell Tumor ◽  
Neuron Specific Enolase ◽  
Granular Cell ◽  
Cell Tumor ◽  
Ultrasound Guided ◽  
Cross Sectional ◽  
Imaging Characteristics ◽  
The Right

Introduction: Granular cell tumor (GCT) is rare, usually benign, with less than a 2% chance of malignancy. It is usually located in the tongue, and affects the breast in only 6% of the reported cases, with incidence of 1:1000 cases of breast carcinoma. Its origin is related to the Schwann cells. It presents itself as a firm, painless, moveable mass, smaller than 3 cm. It can affect men and women in several age groups, and is more frequent among black women, from the 4th to the 6th decades of life. The image mimics malignant lesions. Mammography shows: dense, circumscribed, sometimes spiculated nodules, without associated microcalcifications. The ultrasound showed: solid, hypoechoic, heterogeneous, round, irregular nodule, with irregular halo in some cases. Histologically, there are large, polygonal cells, with eosinophilic, granular cytoplasm displayed in blades or trabeculae, with benign, atypical and malignant variants. Positive immunohistochemical (IHC) for markers such as: S00 protein, vimentin, neuron-specific enolase, CD-57, CF-68, inhibin alpha, SOX-10, calretinin, PGP9.5, Gap43. The treatment is the excision of the lesion with margins, with low risk of recurrence. Objective: To describe a case of GCT in Hospital Pérola Byington in January/2019. Method: Cross-sectional, descriptive case report obtained through a medical chart review. Results: S.R.P, 56-year old female, white patient, assisted in January, 2019, complaining of a nodule in the right breast for three months. She denies comorbidities, is not aware of family history of cancer. G1P1N, menacme from the age of 13 to 53, denies hormone therapies. At the first examination: nodule measuring 2.5x2.5cm, in the right SLQ, retracting the nipple; right axilla (RA) showing palpable lymph node. Mammography shows a nodule in the right breast (RB), with irregular shape, partially defined borders, measuring 3.8 cm, located in SLQ(B4)-. An ultrasound guided nodule core biopsy at 10hMD, measuring 2.24x1.52x1.97, RA without findings. Biopsy suggests GCT (without IHC). The choice was to perform an ultrasound guided mammotome with IHC, confirming the GCT (positive for S-100, CD-68, enolase and vimentin), submitted to sectorectomy for the excision of the residual lesion. Conclusions: GCT is rare, benign, in most cases; however, when clinical, epidemiological and imaging characteristics suggest cancer, it is necessary to make an anatomopathological confirmation with IHC and excision of the lesion.

scholarly journals Granular Cell Tumor of Breast: Rare Tumor Masquerading as Malignancy

2020 ◽  
Vol 42 (1) ◽  
pp. 62-64
Author(s):  
Suzita Hirachan ◽  
Yogendra P Singh ◽  
Anamika Jha ◽  
Usha Manandhar
Keyword(s):  
Granular Cell Tumor ◽  
Periodic Acid ◽  
Granular Cell ◽  
Cell Tumor ◽  
Periodic Acid Schiff ◽  
Granular Eosinophilic Cytoplasm ◽  
Eosinophilic Cytoplasm ◽  
S 100 ◽  
Proper Diagnosis ◽  
The Right

Granular cell tumor (GCT) is a rare soft tissue tumor that arises from the Schwann cells of peripheral nerves. It was first postulated by Abrikossoff in 1926 as Myoblastoma. About 5-15% of these tumors occur in the breast and less than 1% has the potential to be malignant. Here we present a case of 41 years old premenopausal woman with Benign GCT of the right breast, having clinically malignant features. The clinical and radiological features of GCT are similar to malignant lump. However, histology showing presence of sheets of polygonal cells with abundant granular eosinophilic cytoplasm with round nuclei and granules with Periodic acid–Schiff (PAS) positive, diastase resistant and S-100 antigen positive are confirmatory. Treatment of Granular cell tumor is wide local excision. There is apparently no role of chemotherapy and radiotherapy. The presence of GCT in the breast is quite rare and clinically as well as radiologically it may mimic malignancy, however with histopathology and appropriate immunohistochemistry, proper diagnosis can be made.

scholarly journals Metastasizing Malignant Granular Cell Tumor (Abrikossoff Tumor) of the Anterior Abdominal Wall, with Prolonged Survival

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Yara A. Alnashwan ◽  
Khaled A. H. Ali ◽  
Samir S. Amr
Keyword(s):  
Abdominal Wall ◽  
Poor Prognosis ◽  
Granular Cell Tumor ◽  
Anterior Abdominal Wall ◽  
Granular Cell ◽  
Cell Tumor ◽  
Prolonged Survival ◽  
Review Of The Literature ◽  
Malignant Granular Cell Tumor ◽  
The Right

Malignant granular cell tumor (MGCT) is a rare high-grade mesenchymal tumor of Schwann cell origin. MGCTs commonly affect thigh, extremity, and trunk; however, involvement of the abdominal wall is quite rare. It has poor prognosis with 39% mortality rate in 3-year interval. We report a 50-year-old female who had MGCT arising in the anterior abdominal wall and developed massive metastatic deposits in both lungs and in the right inguinal lymph nodes, with prolonged survival for 11 years. A brief review of the literature is presented.

scholarly journals Pazopanib monotherapy in a patient with a malignant granular cell tumor originating from the right orbit: A case report

2015 ◽  
Vol 10 (2) ◽  
pp. 972-974 ◽  
Author(s):  
SACHI MORITA ◽  
MARIKO HIRAMATSU ◽  
MIHOKO SUGISHITA ◽  
BISHAL GYAWALI ◽  
TAKASHI SHIBATA ◽  
...  
Keyword(s):  
Case Report ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor ◽  
Malignant Granular Cell Tumor ◽  
The Right

scholarly journals A Rare Case of Granular Cell Tumor of the Anal Region: Diagnostic Difficulty to Masses in the Anal Area

2014 ◽  
Vol 99 (1) ◽  
pp. 45-47 ◽  
Author(s):  
Takaaki Fujii ◽  
Hiroki Morita ◽  
Satoru Yamaguchi ◽  
Soichi Tsutsumi ◽  
Takayuki Asao ◽  
...  
Keyword(s):  
Rare Case ◽  
Granular Cell Tumor ◽  
Polypoid Lesion ◽  
Granular Cell ◽  
Clinical Findings ◽  
Japanese Woman ◽  
Cell Tumor ◽  
The Body ◽  
Current Case ◽  
Anal Region

Abstract Granular cell tumor may be located anywhere in the body; however, the gastrointestinal tract is infrequently involved and anal granular cell tumors are extremely rare. We report herein a rare case of granular cell tumor in the anal region. In the current case, a 66-year-old Japanese woman was found to have a polypoid lesion in the anus with hemorrhoids. The mass detected as an anal polypoid lesion with ulceration was resected and diagnosed as granular cell tumor by histologic examination. Granular cell tumor of the anal region is rare, and benign perianal polypoid lesions are relatively uncommon clinical findings. They might present diagnostic challenges to surgeons and pathologists. Awareness of the differential diagnosis of granular cell tumor and careful microscopic examination might allow proper management and diagnosis.

scholarly journals Granular Cell Tumor of the Tongue: A Rare Case Presentation of a 14 Years Old Girl

2021 ◽  
pp. 1-2
Author(s):  
Mansour Nacouzi ◽  
Keyword(s):  
Granular Cell Tumor ◽  
Benign Neoplasm ◽  
Granular Cell ◽  
Cell Tumor ◽  
Lateral Border ◽  
Case Presentation ◽  
Granular Cytoplasm ◽  
The Right ◽  
Sixth Decade ◽  
Mobile Tongue

Granular cell tumor or Abrikossoff ’s tumor is an infrequent tumor that can arise in most organs, and especially in the ENT area. It is a usually benign neoplasm, that can lead to a misdiagnose of malignancy. It affects both sex, between the fourth and the sixth decade. We present in this report a case of a 14 years old girl with a slowly growing lesion on the right lateral border of the mobile tongue. The biopsy showed a proliferation of large cells with a granular cytoplasm that expressed two immunohistochemistry markers: CD68 and S100 antibodies. Surgical resection was completed with a one centimeter margin.The rare issue about this case is the age of presentation: the age of the patient is 14, whereas this tumor usually affects adult patients.

scholarly journals Pediatric Granular Cell Tumor of the Breast: A Case Report and Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-6
Author(s):  
Nathan P. Heinzerling ◽  
Shannon M. Koehler ◽  
Sara Szabo ◽  
Amy J. Wagner
Keyword(s):  
Granular Cell Tumor ◽  
Granular Cell ◽  
Excisional Biopsy ◽  
Cell Tumor ◽  
The Body ◽  
Positive Staining ◽  
Review Of The Literature ◽  
Rare Presentation ◽  
Breast Masses

Objective. Granular cell tumors arise from neurogenic mesenchymal stem cells and can occur anywhere throughout the body. They rarely present as breast masses and should be included in the differential diagnosis of pediatric breast neoplasms. We report a rare presentation of a pediatric breast granular cell tumor and a review of the literature.Participant. A 15-year-old female presented with an enlarging breast mass. She underwent ultrasound imaging and excisional biopsy, which revealed a granular cell tumor. Granular cell tumors of the breast are difficult to diagnose using ultrasound and mammography due to numerous similarities to other breast masses. Histopathologic staining best differentiates breast granular cell tumors from other breast masses with their positive staining for S100, CD68, and neurospecific enolase.Conclusion. Although rare, granular cell tumors of the breast should be considered as a possible diagnosis for pediatric breast masses to allow for proper management and follow-up for these patients. Although rare, these tumors do have malignant potential necessitating a correct and timely diagnosis.

A CASE REPORT OF MULTIPLE GRANULAR CELL TUMORS OF TONGUE WITH REVIEW OF LITERATURE.

2021 ◽  
pp. 27-28
Author(s):  
Anish Poorna T ◽  
Ramya A ◽  
Joshna EK ◽  
Bobby John
Keyword(s):  
Case Report ◽  
Head And Neck ◽  
Hard Palate ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor ◽  
The Body ◽  
Review Of Literature ◽  
Architectural Patterns ◽  
Malignant Lesions

Also called as Abrikossoff's tumor, the granular cell tumor (GCT) can occur in any part of the body, most of them occur in the head and neck especially in the tongue, cheek and palate. Almost three fourth of the lesions seen in head and neck are present over the tongue, oral mucosa or hard palate. Both benign and malignant lesions have been reported; although occurrence of malignancy is rare, comprising of 2% of all granular cell tumors. Here we present a case report of granular cell tumor of tongue at two different sites in a 17-year-old girl with a brief review of literature on granular cell tumors. Although oral GCTs exhibit a benign behavior they may demonstrate a wide variety of features and architectural patterns. Rather than a true neoplasm, GCTs could be regarded as lesions that reect a local metabolic or reactive change.

scholarly journals Biliary Duct Granular Cell Tumor: A Rare But Surgically Curable Benign Tumor

HPB Surgery ◽  
1993 ◽  
Vol 6 (4) ◽  
pp. 311-317 ◽  
Author(s):  
W. David Lewis ◽  
Joseph F. Buell ◽  
Roger L. Jenkins ◽  
Peter A. Burke
Keyword(s):  
Granulosa Cell ◽  
Granular Cell Tumor ◽  
Granulosa Cell Tumor ◽  
Granular Cell ◽  
Surgical Excision ◽  
Biliary Tree ◽  
Cell Tumor ◽  
The Body ◽  
Benign Tumors ◽  
Biliary Duct

Granulosa cell tumors are rare benign tumors which may be found throughout the body. Rare cases are isolated within the biliary tree. If completely resected, surgical excision is curative.A case of biliary duct granulosa cell tumor is presented with review of the world’s literature on this topic.

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