scholarly journals Vitamin D Intoxication Presenting as Subacute Encephalopathy—A Case Report

2021 ◽  
Vol 8 ◽  
pp. 2329048X2110080
Author(s):  
Naik Tripty ◽  
Jagzape Tushar ◽  
Jondhale Sunil
Keyword(s):  
Vitamin D ◽  
Case Report ◽  
Serum Calcium ◽  
Volume Status ◽  
Developmental Milestones ◽  
Frequent Monitoring ◽  
Vitamin D Intoxication ◽  
Life Threatening ◽  
High Doses

Vitamin D intoxication is uncommon in children and is more commonly suspected in the setting of ingestion of high doses of vitamin D. Its manifestations can be non specific and varied ranging from mild like constipation and vomiting to life threatening like arrhythmias and encephalopathy. Here we present a 14 month female who presented with loss of milestones, floppiness, and poor interaction with mother. She was detected to have hypercalcemia and was subsequently diagnosed with vitamin D intoxication. She was successfully treated with hydration, furosemide, prednisolone and frequent monitoring of electrolytes, electrocardiography and volume status. Subsequently as her serum calcium levels normalized with therapy, she became alert, conscious and started achieving developmental milestones.

scholarly journals VITAMIN D INTOXICATION IN A PATIENT WITH RELAPSING-REMITTING MULTIPLE SCLEROSIS – CASE REPORT

2015 ◽  
Vol 14 (3) ◽  
pp. 166-168
Author(s):  
Ioana Cociasu ◽  
◽  
Irene Davidescu ◽  
Ioan Buraga ◽  
Bogdan Ovidiu Popescu ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Case Report ◽  
Vitamin D Supplementation ◽  
Multiple Sclerosis Case ◽  
Vitamin D Intoxication ◽  
Relapsing Remitting ◽  
Vitamin D Supplements ◽  
High Doses ◽  
Relapsing Remitting Multiple Sclerosis

Lately, vitamin D has been a hot topic among multiple sclerosis specialists. Vitamin D supplementation is being thoroughly researched in order to establish whether or not it is useful in the treatment of multiple sclerosis. We present the case of a patient with multiple sclerosis, who, after searching online, decided to administer vitamin D supplements in high doses; subsequently he was admitted to our for clinic symptoms consistent with vitamin D intoxication.

Vitamin D intoxication caused hypercalcemia: Case report

2017 ◽  
Author(s):  
Kader Ugur ◽  
Hakan Artas ◽  
Mehmet Balin ◽  
Esra Aykut ◽  
Selcuk Demircan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Case Report ◽  
Vitamin D Intoxication

Vitamin D intoxication complicated with parathormon treatment in elderly: a case report

2017 ◽  
Author(s):  
S Nur Boysan ◽  
Burcu Altunrende ◽  
Levent Dalar ◽  
M Eren Acik ◽  
I Polat Canpolat ◽  
...  
Keyword(s):  
Vitamin D ◽  
Case Report ◽  
Vitamin D Intoxication

Vitamin D intoxication and therapy with alendronate (case report and review of literature)

2006 ◽  
Vol 165 (8) ◽  
pp. 583-584 ◽  
Author(s):  
Zerrin Orbak ◽  
Hakan Doneray ◽  
Filiz Keskin ◽  
Ahmet Turgut ◽  
Handan Alp ◽  
...  
Keyword(s):  
Vitamin D ◽  
Case Report ◽  
Review Of Literature ◽  
Vitamin D Intoxication

Extrarenal synthesis of 1,25-dihydroxyvitamin D: Sensitivity to glucocorticoid treatment

1987 ◽  
Vol 72 (3) ◽  
pp. 329-334 ◽  
Author(s):  
Silvano Adami ◽  
G. Graziani ◽  
D. Tartarotti ◽  
R. Cappelli ◽  
S. Casati ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Calcium ◽  
Glucocorticoid Treatment ◽  
Prednisone Therapy ◽  
Hydroxyvitamin D ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
Prednisone Treatment ◽  
Vitamin D Intoxication ◽  
Before And After

1. The response of circulating 1,25-dihydroxyvitamin D [l,25-(OH)2D] to challenge with vitamin D treatment both before and after 7–10 days of prednisone therapy (25 mg/day) was investigated in five anephric subjects, six patients with chronic renal failure (CRF), two patients with vitamin D intoxication and four patients with hypoparathyroidism. 2. In anephric subjects serum 25-hydroxyvitamin D [25-(OH)D] rose from 58 ± 48 (sd) to 377±221 (sd) nmol/l after administration of 150 μg of 25-(OH)D3 for 1 month. Serum l,25-(OH)2D, which was barely detectable in only two out of five patients under basal conditions, rose to 30 ± 21 pmol/l after 2 weeks of therapy with 25-(OH)D3, but fell to 10 ± 5 pmol/l during prednisone treatment. 3. In CRF patients circulating l,25-(OH)2D rose from 37 ± 24 to 58 ± 24 pmol/l during 25-(OH)D3 therapy, but fell to 41 ± 31 pmol/l during prednisone treatment. In two patients with rheumatoid arthritis, hypercalcaemia due to vitamin D intoxication was associated with raised levels of 1,25-(OH)2D (288 and 317 pmol/l). Administration of prednisore resulted in suppression of l,25-(OH)2D levels (132 and 96 pmol/l respectively) and reduction of serum calcium to within the normal range. 4. In the hypoparathyroid patients prednisone therapy did not affect circulating 25-(OH)D levels but serum l,25-(OH)2D fell from 192 ± 42 to 117 ± 23 pmol/l and serum calcium from 2.41 ± 0.21 to 2.20 ± 0.05 mmol/l. 5. These findings indicate that a steroid sensitive extrarenal production of l,25-(OH)2D may occur in all subjects with a threshold serum concentration of the precursor 25-(OH)D.

scholarly journals Vitamin D intoxication: case report

2014 ◽  
Vol 12 (2) ◽  
pp. 242-244 ◽  
Author(s):  
Tatiana Aporta Marins ◽  
Tatiana de Fátima Gonçalves Galvão ◽  
Fernando Korkes ◽  
Domingos Augusto Cherino Malerbi ◽  
Arnaldo José Ganc ◽  
...  
Keyword(s):  
Vitamin D ◽  
Renal Function ◽  
Case Report ◽  
Hypervitaminosis D ◽  
Vitamin D Intoxication

Hypervitaminosis D is a rarely reported condition. In general it is only perceived when hypercalcemia is not resolved. The use of vitamin D has increased in recent years because of its benefits, but as a result, intoxication cases have occurred more frequently. This report describes a patient who presented worsening of renal function and hypercalcemia. After investigation, vitamin D intoxication was confirmed and it was due to an error in compounding.

A case of severe, irreversible hypocalcemia after one dose of pamidronate administered for hypercalcemia of malignancy

2018 ◽  
Vol 25 (7) ◽  
pp. 1787-1793 ◽  
Author(s):  
Sophie Kim
Keyword(s):  
Vitamin D ◽  
Case Report ◽  
Vitamin D Deficiency ◽  
Cancer Patients ◽  
Serum Calcium ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Elevated Serum ◽  
Baseline Serum ◽  
Hypercalcemia Of Malignancy

This is a case report of a patient who developed severe, irreversible hypocalcemia after receiving one dose of pamidronate 90 mg for hypercalcemia of malignancy. Hypocalcemia is a known risk of bisphosphonate treatments, but the incidence of severe hypocalcemia is rare, and the risk factors are well established. However, in the treatment of hypercalcemia of malignancy, the treatment objective is to reduce the elevated serum calcium level, and the bisphosphonate is usually given as one time dose only. The potential for developing severe hypocalcemia may not be considered a significant concern in this setting compared to the setting of the treatment of bone metastasis, where the baseline serum calcium level is not elevated and the bisphosphonate is administered at a regular interval of every three to four weeks. Furthermore, there is unawareness of prevalence of vitamin D deficiency in cancer patients, especially in those with advanced cancer, which may lead to inadvertent, severe hypocalcemia from bisphosphonate treatment. The objective of this case report is to bring awareness to the risk of severe hypocalcemia in patients with hypercalcemia of malignancy and the high prevalence of unrecognized vitamin D deficiency in cancer patients.

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