Long-term follow-up outcome after surgical treatment for lesional temporal lobe epilepsy

We present an update of the literature concerning long-term neuropsychological outcomes following surgery for refractory temporal lobe epilepsy (TLE). A thorough search was conducted through the PubMed and Medline electronic databases for studies investigating neuropsychological function in adult patients undergoing resective TLE surgery and followed for a mean/median > five years period. Two independent reviewers screened citations for eligibility and assessed relevant studies for the risk of bias. We found eleven studies fulfilling the above requirements. Cognitive function remained stable through long-term follow up despite immediate post-surgery decline; a negative relation between seizure control and memory impairment has emerged and a possible role of more selective surgery procedures is highlighted.

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Long-Term Follow-Up of Ictal Asystole in Temporal Lobe Epilepsy: Is Permanent Pacemaker Therapy Needed?

Journal of Cardiovascular Electrophysiology ◽

10.1111/jce.13009 ◽

2016 ◽

Vol 27 (8) ◽

pp. 930-936 ◽

Cited By ~ 10

Author(s):

RITSUKO KOHNO ◽

HARUHIKO ABE ◽

NAOKI AKAMATSU ◽

DAVID G. BENDITT

Keyword(s):

Temporal Lobe Epilepsy ◽

Temporal Lobe ◽

Permanent Pacemaker ◽

Pacemaker Therapy ◽

Long Term Follow Up

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Quality of life related to surgical treatment in patients with temporal lobe epilepsy due to mesial temporal sclerosis

Journal of Epilepsy and Clinical Neurophysiology ◽

10.1590/s1676-26492006000700009 ◽

2006 ◽

Vol 12 (4) ◽

pp. 233-241 ◽

Cited By ~ 2

Author(s):

Neide Barreira Alonso ◽

Tatiana Indelicato da Silva ◽

Ana Carolina Westphal-Guitti ◽

Auro Mauro Azevedo ◽

Luís Otávio Sales Ferreira Caboclo ◽

...

Keyword(s):

Surgical Treatment ◽

Temporal Lobe Epilepsy ◽

Temporal Lobe ◽

Well Being ◽

Mesial Temporal Sclerosis ◽

Post Surgery ◽

Intractable Seizures ◽

Long Term Follow Up ◽

Cognitive Problems

INTRODUCTION: Surgery is widely accepted as a modality of treatment for medically intractable seizures and the main goals of surgery as reduction or elimination of seizures without significant compromise in neurological function and improving QOL. PURPOSE: To assess QOL pre- and post-surgery in a sample of patients with temporal lobe epilepsy (TLE) due to mesial temporal sclerosis (MTS). METHODS: Thirty-five consenting subjects who had undergone corticoamygdalo-hipocampetomy were included in this study. They answered the ESI-55 before and six months after surgical treatment. Analyses of Variance (ANOVA) was used to study the changes in QOL and we also determined the effect-size of the sample. RESULTS: After surgical treatment 18 (51%) subjects were seizure free, 10 (29%) had only auras and seven (20%) had partial seizures. The post-operative mean scores were higher than pre-operative scores, except for Cognitive Function and Limitation due to Cognitive Problems in the group with seizures. A significant improvement in QOL post-surgery was observed in the domains Health-Perception (1.24), Emotional-Well-being (1.32) and Energy/Fatigue (1.43). CONCLUSION: A long-term follow-up is necessary to identify meanigful changes after the surgery.

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