Lethal Toxicity After 5-Fluorouracil Chemotherapy and Its Possible Relationship to Dihydropyrimidine Dehydrogenase Deficiency: A Case Report and Review

2004 ◽  
Vol 16 (6) ◽  
pp. 599-603 ◽  
Author(s):  
R. Díaz ◽  
Á. Segura ◽  
J. Aparicio ◽  
V. Calderero ◽  
Á. Guerrero ◽  
...  
Keyword(s):  
Case Report ◽  
Dehydrogenase Deficiency ◽  
Dihydropyrimidine Dehydrogenase ◽  
Lethal Toxicity ◽  
Dihydropyrimidine Dehydrogenase Deficiency

5-Fluorouracil Neurotoxicity in the Absence of Dihydropyrimidine Dehydrogenase Deficiency Case Report

2022 ◽  
pp. 194187442110689
Author(s):  
Rebecca Jules ◽  
Arushi Thaper ◽  
Ryan Foster ◽  
Pouya Ameli ◽  
Christopher Robinson ◽  
...  
Keyword(s):  
Case Report ◽  
Adverse Reactions ◽  
Colorectal Adenocarcinoma ◽  
Dehydrogenase Deficiency ◽  
Dihydropyrimidine Dehydrogenase ◽  
Severe Complication ◽  
Diffusion Restriction ◽  
Increased Risk ◽  
Dihydropyrimidine Dehydrogenase Deficiency ◽  
Leucovorin Calcium

5 fluorouracil (5-FU)-related neurotoxicity is a rare and severe complication of 5-FU administration. Dihydropyrimidine dehydrogenase (DPD) deficiency is associated with an increased risk of serious adverse reactions due to its role in 5-FU metabolism. We report a case of acute reversible neurotoxicity with global areas of diffusion restriction in a patient with colorectal adenocarcinoma being treated with leucovorin calcium, 5-fluorouracil, and oxaliplatin (FOLFOX) without DPD deficiency following uridine triacetate administration.

Dihydropyrimidine Dehydrogenase Deficiency Caused by a Novel Genomic Deletion c.505_513del ofDPYD

2010 ◽  
Vol 29 (4-6) ◽  
pp. 509-514 ◽  
Author(s):  
A. B. P. van Kuilenburg ◽  
J. Meijer ◽  
G. Gökcay ◽  
T. Baykal ◽  
M. E. Rubio-Gozalbo ◽  
...  
Keyword(s):  
Dehydrogenase Deficiency ◽  
Dihydropyrimidine Dehydrogenase ◽  
Genomic Deletion ◽  
Dihydropyrimidine Dehydrogenase Deficiency
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