Complete molecular response of e6a2 BCR-ABL–positive acute myeloid leukemia to imatinib then dasatinib
Keyword(s):
De Novo
◽
De novo presentation of acute myeloid leukemia (AML) expressing the Philadelphia (Ph) chromosomal abnormality is rare and is associated with a dismal prognosis. To date, reported cases of Ph+ AML have expressed either the e13a2 or e14a2 BCR-ABL fusion transcripts. We report a unique case of de novo AML expressing the e6a2 fusion transcript and describe disease sensitivity to both imatinib before allogeneic stem-cell transplantation and dasatinib for AML relapse after allogeneic stem-cell transplantation. Furthermore, we report that sustained molecular remission has been achieved despite withdrawal of tyrosine kinase inhibitor (TKI) therapy.
2010 ◽
Vol 25
(1)
◽
pp. 110
◽
2010 ◽
Vol 28
(4)
◽
pp. e54-e55
◽
2012 ◽
Vol 18
(2)
◽
pp. S292
2013 ◽
Vol 7
(2)
◽
pp. 301-315
◽