scholarly journals Interleukin-13 is overexpressed in cutaneous T-cell lymphoma cells and regulates their proliferation

Blood ◽  
2015 ◽  
Vol 125 (18) ◽  
pp. 2798-2805 ◽  
Author(s):  
Larisa J. Geskin ◽  
Sara Viragova ◽  
Donna B. Stolz ◽  
Patrizia Fuschiotti
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
Therapeutic Targets ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Lymphoma Cells ◽  
Interleukin 13 ◽  
Key Points ◽  
Autocrine Factor

Key PointsIL-13 is an autocrine factor for CTCL. IL-13 and its receptors represent novel markers of CTCL malignancy and potential therapeutic targets for intervention.

scholarly journals Diminished microRNA-29b level is associated with BRD4-mediated activation of oncogenes in cutaneous T-cell lymphoma

Blood ◽  
2018 ◽  
Vol 131 (7) ◽  
pp. 771-781 ◽  
Author(s):  
Rebecca Kohnken ◽  
Jing Wen ◽  
Bethany Mundy-Bosse ◽  
Kathleen McConnell ◽  
Ashleigh Keiter ◽  
...  
Keyword(s):  
T Cell ◽  
Disease Severity ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Promoter Regions ◽  
Therapeutic Targeting ◽  
Key Points

Key Points CTCL patients have decreased miR-29b levels and increased BRD4 binding occupancy at promoter regions of tumor-associated genes. Therapeutic targeting of miR-29b and BRD4 in CTCL mice results in significantly decreased disease severity and progression.

scholarly journals Apoptosis Induction by SAHA in Cutaneous T-Cell Lymphoma Cells Is Related to Downregulation of c-FLIP and Enhanced TRAIL Signaling

2012 ◽  
Vol 132 (9) ◽  
pp. 2263-2274 ◽  
Author(s):  
Nadya Al-Yacoub ◽  
Lothar F. Fecker ◽  
Markus Möbs ◽  
Michael Plötz ◽  
Frank K. Braun ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Apoptosis Induction ◽  
Lymphoma Cells ◽  
Trail Signaling

scholarly journals 589 Effects of CCR4 antagonists in cutaneous T-cell lymphoma cells

2020 ◽  
Vol 140 (7) ◽  
pp. S80
Author(s):  
J.S. Enriquez ◽  
P. Bijani ◽  
M. Duvic ◽  
X. Ni
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Lymphoma Cells

scholarly journals 676 Exploring novel therapeutic targets in the treatment of cutaneous T-cell lymphoma

2019 ◽  
Vol 139 (5) ◽  
pp. S116
Author(s):  
S. Yumeen ◽  
A.O. King ◽  
S. Kim ◽  
J. Lewis ◽  
K. Carlson ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
Therapeutic Targets ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Novel Therapeutic

scholarly journals Humanization of an Anti-CCR4 Antibody That Kills Cutaneous T-Cell Lymphoma Cells and Abrogates Suppression by T-Regulatory Cells

2012 ◽  
Vol 11 (11) ◽  
pp. 2451-2461 ◽  
Author(s):  
De-Kuan Chang ◽  
Jianhua Sui ◽  
Shusheng Geng ◽  
Asli Muvaffak ◽  
Mei Bai ◽  
...  
Keyword(s):  
T Cell ◽  
T Regulatory Cells ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Regulatory Cells ◽  
Lymphoma Cells

MicroRNA-150 inhibits tumor invasion and metastasis by targeting the chemokine receptor CCR6, in advanced cutaneous T-cell lymphoma

Blood ◽  
2014 ◽  
Vol 123 (10) ◽  
pp. 1499-1511 ◽  
Author(s):  
Mitsugu Ito ◽  
Kazuaki Teshima ◽  
Sho Ikeda ◽  
Akihiro Kitadate ◽  
Atsushi Watanabe ◽  
...  
Keyword(s):  
T Cell ◽  
Chemokine Receptor ◽  
Tumor Invasion ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Autocrine Signaling ◽  
Invasion And Metastasis ◽  
Multiple Organs ◽  
Key Points

Key Points Aberrantly diminished expression of miR-150 allows advanced CTCL to invade multiple organs with upregulation of CCR6. MiR-150 inhibits IL-22-CCL20-CCR6 autocrine signaling in advanced CTCL.

Cutaneous T-cell lymphoma cells are sensitive to rapamycin

2010 ◽  
Vol 19 (9) ◽  
pp. 800-805 ◽  
Author(s):  
Melanie Kremer ◽  
Katja Sliva ◽  
Claus-Detlev Klemke ◽  
Barbara S. Schnierle
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Lymphoma Cells
Sign in / Sign up

Export Citation Format

Share Document