scholarly journals Hyperlipidemia, hypercoagulability, and accelerated thrombosis: studies in congenitally hyperlipidemic rats and in rats and monkeys with induced hyperlipidemia

Blood ◽  
1976 ◽  
Vol 47 (2) ◽  
pp. 275-286
Author(s):  
WM Kim ◽  
C Merskey ◽  
QB Deming ◽  
HN Adel ◽  
H Wolinsky ◽  
...  
Keyword(s):  
Serum Cholesterol ◽  
Plasma Lipids ◽  
Blood Platelets ◽  
Elevated Serum ◽  
Coagulation Factors ◽  
Normal Diet ◽  
Factor Vii ◽  
Factor X ◽  
Cholesterol Levels ◽  
Elevated Serum Cholesterol

Inbred Carworth Farms Nelson (CFN) congenitally hyperlipidemic rats had significantly shorter coagulation and prothrombin times and higher levels of coagulation factors, II, V, VII, VIII, and X than did controls. Conversely, congenitally hypolipidemic rats of the same strain had significantly longer coagulation and prothrombin times and lower levels of factors II, V, VII, X and XII and of blood platelets than did controls. A loop-shaped polyethylene cannula was inserted into the aorta to assess the potential for thrombosis. The hyperlipidemic group obstructed this significantly faster and the hypolipidemic group slower than did the controls. Normal CFN rats made hypertensive by unilateral renal artery clip developed hypertension together with significantly elevated serum cholesterol and factor VII and X levels. Rhesus monkeys with diet-induced hyperlipidemia showed shorter prothrombin times and higher factor X levels than did controls on normal diet. By selective breeding, two groups of squirrel monkeys were obtained. Both groups had similar serum cholesterol levels on a normal diet but one group (hyperresponders) showed higher serum cholesterol levels on a cholesterol-containing diet than did the other (hyporesponder) group. Both groups showed significantly elevated levels of factors II, V, VII, IX and X on a cholesterol-containing diet. There was good correlation between the levels of many coagulation factors and serum cholesterol in both rats and monkeys. If thrombosis is important in the genesis of atherosclerosis, these findings could indicate that elevation of plasma lipids may play a role, via the coagulation pathway, in the production of human vascular disease.

scholarly journals Hyperlipidemia, hypercoagulability, and accelerated thrombosis: studies in congenitally hyperlipidemic rats and in rats and monkeys with induced hyperlipidemia

Blood ◽  
1976 ◽  
Vol 47 (2) ◽  
pp. 275-286 ◽  
Author(s):  
WM Kim ◽  
C Merskey ◽  
QB Deming ◽  
HN Adel ◽  
H Wolinsky ◽  
...  
Keyword(s):  
Serum Cholesterol ◽  
Plasma Lipids ◽  
Blood Platelets ◽  
Elevated Serum ◽  
Coagulation Factors ◽  
Normal Diet ◽  
Factor Vii ◽  
Factor X ◽  
Cholesterol Levels ◽  
Elevated Serum Cholesterol

Abstract Inbred Carworth Farms Nelson (CFN) congenitally hyperlipidemic rats had significantly shorter coagulation and prothrombin times and higher levels of coagulation factors, II, V, VII, VIII, and X than did controls. Conversely, congenitally hypolipidemic rats of the same strain had significantly longer coagulation and prothrombin times and lower levels of factors II, V, VII, X and XII and of blood platelets than did controls. A loop-shaped polyethylene cannula was inserted into the aorta to assess the potential for thrombosis. The hyperlipidemic group obstructed this significantly faster and the hypolipidemic group slower than did the controls. Normal CFN rats made hypertensive by unilateral renal artery clip developed hypertension together with significantly elevated serum cholesterol and factor VII and X levels. Rhesus monkeys with diet-induced hyperlipidemia showed shorter prothrombin times and higher factor X levels than did controls on normal diet. By selective breeding, two groups of squirrel monkeys were obtained. Both groups had similar serum cholesterol levels on a normal diet but one group (hyperresponders) showed higher serum cholesterol levels on a cholesterol-containing diet than did the other (hyporesponder) group. Both groups showed significantly elevated levels of factors II, V, VII, IX and X on a cholesterol-containing diet. There was good correlation between the levels of many coagulation factors and serum cholesterol in both rats and monkeys. If thrombosis is important in the genesis of atherosclerosis, these findings could indicate that elevation of plasma lipids may play a role, via the coagulation pathway, in the production of human vascular disease.

Increased Activity of Vitamin K-Dependent Clotting Factors in Human Hyperlipoproteinaemia – Association with Cholesterol and Triglyceride Levels

1977 ◽  
Vol 38 (02) ◽  
pp. 0465-0474 ◽  
Author(s):  
M Constantino ◽  
C Merskey ◽  
D. J Kudzma ◽  
M. B Zucker
Keyword(s):  
Vitamin K ◽  
Plasma Lipids ◽  
Coagulation Factors ◽  
Clotting Factor ◽  
Factor X ◽  
Clotting Factors ◽  
Blood Coagulation Factors ◽  
Cholesterol Levels ◽  
Type V ◽  
Increased Activity

SummaryLevels of blood coagulation factors, cholesterol and triglyceride were measured in human plasma. Prothrombin was significantly elevated in type Ha hyperlipidaemia; prothrombin and factors VII, IX and X in type lib; and prothrombin and factors VII and IX in type V. Multiple regression analysis showed significant correlation between the levels of these plasma lipids and the vitamin K-dependent clotting factors (prothrombin, factors VII, IX and X). Higher cholesterol levels were associated with higher levels of prothrombin and factor X while higher triglyceride levels were associated with higher levels of these as well as factors VII and IX. Prothrombin showed a significant cholesterol-triglyceride interaction in that higher cholesterol levels were associated with higher prothrombin levels at all levels of triglyceride, with the most marked effects in subjects with higher triglyceride levels. Higher prothrombin levels were noted in subjects with high or moderately elevated (but not low) cholesterol levels. Ultracentrifugation of plasma in a density of 1.21 showed activity for prothrombin and factors VII and X only in the lipoprotein-free subnatant fraction. Thus, a true increase in clotting factor protein was probably present. The significance of the correlation between levels of vitamin K-dependent clotting factors and plasma lipids remains to be determined.

Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways

2004 ◽  
Vol 10 (4) ◽  
pp. 416-421 ◽  
Author(s):  
Harry Björkbacka ◽  
Vidya V Kunjathoor ◽  
Kathryn J Moore ◽  
Stephanie Koehn ◽  
Christine M Ordija ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Signaling Pathways ◽  
Serum Cholesterol ◽  
Elevated Serum ◽  
Cholesterol Levels ◽  
Elevated Serum Cholesterol

PYRIDOXINE DEFICIENCY AND CHOLESTEROGENESIS IN THE CHICK

1964 ◽  
Vol 42 (8) ◽  
pp. 1161-1168 ◽  
Author(s):  
P. J. Lupien ◽  
B. B. Migicovsky
Keyword(s):  
Serum Cholesterol ◽  
Elevated Serum ◽  
Normal Serum ◽  
Liver Cholesterol ◽  
Acetate Incorporation ◽  
Deficient Diet ◽  
Pyridoxine Deficiency ◽  
Cholesterol Levels ◽  
Normal States ◽  
Elevated Serum Cholesterol

Physiological disturbances common to B6 avitaminosis were clearly manifested when 3-day-old chicks were fed a pyridoxine-deficient diet for 8 days. Body and liver weights were depressed but were restored to quasi-normal states after 4 days of pyridoxine supplementation (3 mg/lb diet). The elevated serum cholesterol levels observed were the result of a failure of this parameter to fall at the rate characteristic of a well-fed bird and not to a specific elevation of the serum cholesterol above the starting conditions. Liver cholesterol levels were unaffected by the hypovitaminosis. Pyridoxine supplementation rapidly re-established normal serum cholesterol levels.The significant depression of C14-acetate incorporation into liver and serum cholesterol of 7-day-old pyridoxine-deficient chicks was maintained for the next 8 days. Mevalonate-2-C14 incorporation into liver cholesterol was not significantly depressed by the hypovitaminosis at any time during the study. Unlike the controls, mevalonate-2-C14 incorporation into serum cholesterol was significantly lowered in the 11-day-old pyridoxine-deficient chicks, but not at any other time during the study.The significance of these findings and the possible relationship between these factors are discussed.

Correlation between the Total Cholesterol Serum Concentration Data and Carbamazepine Steady-State Blood Levels in Humans

1983 ◽  
Vol 17 (11) ◽  
pp. 812-814 ◽  
Author(s):  
Leslaw M. Wichliński ◽  
Edmund Sieradzki ◽  
Maria Gruchala
Keyword(s):  
Steady State ◽  
Serum Cholesterol ◽  
Elevated Serum ◽  
Total Serum ◽  
Blood Levels ◽  
Gas Liquid Chromatography ◽  
Concentration Data ◽  
Cholesterol Levels ◽  
Multiple Doses ◽  
Elevated Serum Cholesterol

The purpose of this study was to investigate the pharmacokinetics of carbamazepine at steady state, after multiple doses in patients with elevated serum cholesterol levels. Twelve patients participated in the investigation; patients were divided into two groups according to their total serum cholesterol levels. Each patient received multiple doses of carbamazepine 600 mg po once per day. Blood samples were collected and analyzed for carbamazepine by gas-liquid chromatography. The clearance concept was used to describe the pharmacokinetic behavior of carbamazepine in high and low cholesterol patients. The area under the plasma concentration-time curve was determined by the trapezoidal rule method. This value was used to determine the oral dose clearance. In this study, the authors found that the elevated serum cholesterol and elevated total lipids cause a decrease in drug concentration. The significantly higher values of the total body clearance of carbamazepine, obtained in patients with elevated serum cholesterol levels, may have significance in clinical practice.

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