Mixed lymphoblastic-myelomonoblastic leukemia in treated Hodgkin's disease

In a case of acute leukemia occurring 5.5 yr after diagnosis of Hodgkin's disease, a mixture of lymphoid and myelomonocytoid blasts was identified by morphological, cytochemical, and immunologic methods. The majority of blasts were characterised as lymphoid by their strong expression of nuclear terminal transferase (TdT) enzyme. In contrast, a minor blast population was identified as myelomonocytoid by the strong nonspecific esterase positivity and lack of TdT. The two distinct blast cell populations showed different sensitivity to the various chemotherapeutic protocols used.

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Mixed lymphoblastic-myelomonoblastic leukemia in treated Hodgkin's disease

Blood ◽

10.1182/blood.v56.1.129.129 ◽

1980 ◽

Vol 56 (1) ◽

pp. 129-133 ◽

Cited By ~ 22

Author(s):

AG Prentice ◽

AG Smith ◽

KF Bradstock

Keyword(s):

Acute Leukemia ◽

Hodgkin's Disease ◽

Hodgkin’S Disease ◽

Blast Cell ◽

Cell Populations ◽

Nonspecific Esterase ◽

Terminal Transferase ◽

Strong Expression ◽

A Minor

Abstract In a case of acute leukemia occurring 5.5 yr after diagnosis of Hodgkin's disease, a mixture of lymphoid and myelomonocytoid blasts was identified by morphological, cytochemical, and immunologic methods. The majority of blasts were characterised as lymphoid by their strong expression of nuclear terminal transferase (TdT) enzyme. In contrast, a minor blast population was identified as myelomonocytoid by the strong nonspecific esterase positivity and lack of TdT. The two distinct blast cell populations showed different sensitivity to the various chemotherapeutic protocols used.

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Combination chemotherapy-radiotherapy for stage 3 Hodgkin's disease. An acute leukemia group B study

Archives of Internal Medicine ◽

10.1001/archinte.131.3.424 ◽

1973 ◽

Vol 131 (3) ◽

pp. 424-428 ◽

Cited By ~ 1

Author(s):

B. Hoogstraten

Keyword(s):

Acute Leukemia ◽

Combination Chemotherapy ◽

Hodgkin's Disease ◽

Hodgkin’S Disease ◽

Group B ◽

Leukemia Group

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Cytochemical, immunologic, chromosomal, and molecular genetic analysis of a novel cell line derived from Hodgkin's disease

Blood ◽

10.1182/blood.v68.1.285.285 ◽

1986 ◽

Vol 68 (1) ◽

pp. 285-292 ◽

Cited By ~ 106

Author(s):

H Kamesaki ◽

S Fukuhara ◽

E Tatsumi ◽

H Uchino ◽

H Yamabe ◽

...

Keyword(s):

T Cell ◽

Pleural Effusion ◽

Genetic Analysis ◽

Cell Line ◽

Hodgkin's Disease ◽

Hodgkin’S Disease ◽

Molecular Genetic ◽

Molecular Genetic Analysis ◽

Nonspecific Esterase ◽

Human T Cell

Abstract A novel cell line, KM-H2, was established from the pleural effusion of a patient with Hodgkin's disease of mixed cellular type. Multiple phenotypic studies were carried out with this cell line. Acid phosphatase and nonspecific esterase activities were detected. Rosette formation with T lymphocytes and the receptors for C3b and Fc portion of IgG were positive. Among the antigens tested with a total of 22 monoclonal antibodies defining hematopoietic cell subsets or lineages, Ki-1, Leu-M1, MCS1, HLA-DR, and OKT9 antigens were found to be positive. The other antigens reportedly specific for T cells, B cells, natural killer (NK) cells, monocytes, interdigitating reticulum (IR) cells and dendritic reticulum cells were negative. These phenotypic features were identical to those of the Sternberg-Reed (SR) and Hodgkin (H) cells in the fresh materials reported by other researchers. Moreover, the KM-H2 cells and the parental pleural effusion cells shared several structural chromosome anomalies. These findings indicated that the KM-H2 cells are derived from the SR and H cells. Molecular genetic analysis of the KM-H2 cells disclosed that the human immunoglobulin JH gene was rearranged but not the JK gene, and that the human T cell receptor beta chain gene was of the germline type. Based on these properties of the KM-H2 cells, Hodgkin's disease may be derived from a cell lineage other than T cell or B cell.

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Evidence for distinct lymphocytic and monocytic populations in a patient with terminal transferase--positive acute leukemia

Blood ◽

10.1182/blood.v51.6.1051.1051 ◽

1978 ◽

Vol 51 (6) ◽

pp. 1051-1056 ◽

Cited By ~ 55

Author(s):

R Mertelsmann ◽

B Koziner ◽

R Ralph ◽

D Filippa ◽

S McKenzie ◽

...

Keyword(s):

Stem Cell ◽

Acute Leukemia ◽

Clinical Course ◽

Initial Therapy ◽

Cell Populations ◽

Cell Marker ◽

Terminal Transferase ◽

Distinct Cell ◽

Multiple Cell ◽

Marker Studies

Abstract Two distinct cell populations with lymphoblastic and monocytic characteristics were separated and characterized by multiple cell markers in a patient with terminal transferase-positive acute acute leukemia. The clinical course and sequential cell marker studies were consistent with the interpretation of a defect at the level of a common stem cell giving rise to a terminal transferase--positive lymphoblastic cell population at diagnosis and, following initial therapy, a terminal transferase--negative monocytic population.

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