scholarly journals The kidneys in paroxysmal nocturnal hemoglobinuria

Blood ◽  
1981 ◽  
Vol 57 (1) ◽  
pp. 83-89 ◽  
Author(s):  
DA Clark ◽  
SA Butler ◽  
V Braren ◽  
RC Hartmann ◽  
DE Jr Jenkins
Keyword(s):  
Urinary Tract Infection ◽  
Renal Function ◽  
Paroxysmal Nocturnal Hemoglobinuria ◽  
Striking Similarity ◽  
Term Study ◽  
Papillary Necrosis ◽  
Long Term Study ◽  
High Incidence ◽  
Renal Abnormalities

Long-term study of 21 PNH patients revealed an unexpectedly high incidence of functional and anatomic renal abnormalities. Most patients demonstrated varying degrees of hematuria and proteinuria distinct from hemoglobinuria. Evaluation of renal function revealed hyposthenuria, abnormal tubular function, and declining creatinine clearance. Radiologically these patients had enlarged kidneys, cortical infarcts, cortical thinning, and papillary necrosis which were confirmed by autopsy studies. Hypertension developed in eight patients. Urinary tract infection was uncommon. The renal findings bear striking similarity to those of sickle cell anemia. Contrary to the usual opinion, out studies clearly showed evidence of widespread renal pathology in PNH most likely due to repeated microvascular thrombosis similar to the venous thrombosis involving other organs in this disorder.

scholarly journals The kidneys in paroxysmal nocturnal hemoglobinuria

Blood ◽  
1981 ◽  
Vol 57 (1) ◽  
pp. 83-89 ◽  
Author(s):  
DA Clark ◽  
SA Butler ◽  
V Braren ◽  
RC Hartmann ◽  
DE Jr Jenkins
Keyword(s):  
Urinary Tract Infection ◽  
Renal Function ◽  
Paroxysmal Nocturnal Hemoglobinuria ◽  
Striking Similarity ◽  
Term Study ◽  
Papillary Necrosis ◽  
Long Term Study ◽  
High Incidence ◽  
Renal Abnormalities

Abstract Long-term study of 21 PNH patients revealed an unexpectedly high incidence of functional and anatomic renal abnormalities. Most patients demonstrated varying degrees of hematuria and proteinuria distinct from hemoglobinuria. Evaluation of renal function revealed hyposthenuria, abnormal tubular function, and declining creatinine clearance. Radiologically these patients had enlarged kidneys, cortical infarcts, cortical thinning, and papillary necrosis which were confirmed by autopsy studies. Hypertension developed in eight patients. Urinary tract infection was uncommon. The renal findings bear striking similarity to those of sickle cell anemia. Contrary to the usual opinion, out studies clearly showed evidence of widespread renal pathology in PNH most likely due to repeated microvascular thrombosis similar to the venous thrombosis involving other organs in this disorder.

scholarly journals High Incidence of Celiac Disease in a Long-term Study of Adolescents With Susceptibility Genotypes

2017 ◽  
Vol 152 (6) ◽  
pp. 1329-1336.e1 ◽  
Author(s):  
Edwin Liu ◽  
Fran Dong ◽  
Anna E. Barón ◽  
Iman Taki ◽  
Jill M. Norris ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Term Study ◽  
Long Term Study ◽  
High Incidence

Bilateral cervical vagotomy: a long-term study on the unanesthetized dog

1964 ◽  
Vol 206 (2) ◽  
pp. 265-269 ◽  
Author(s):  
Robert S. Shepard ◽  
Albert J. Whitty
Keyword(s):  
Heart Rate ◽  
Diastolic Pressure ◽  
Systolic Pressure ◽  
Complete Loss ◽  
Term Study ◽  
Long Term Study ◽  
High Incidence ◽  
Cervical Vagotomy ◽  
Elevated Heart Rate

Bilateral cervical vagotomy was followed by prolonged changes in heart rate, blood pressure, and respiration, and a progressive deterioration of cardiac function. This study was based on recordings from 18 unanesthetized, unrestrained, reclining dogs prior to and after gastroenterostomy, arterial catheterization, and bilateral cervical vagotomy. During the first 7 days after denervation, the heart rate was almost doubled and the pulse pressure was decreased. The diastolic pressure was increased only on the first day, whereas on the second day after denervation the systolic pressure became significantly lower. The markedly elevated heart rate was maintained for 3 weeks. There was a complete loss of inspiratory tachycardia for 20 weeks, a prolonged inspiratory period for 2 weeks, and a high incidence of retching and vomiting for over 43 weeks. Although the animals refused to exercise strenuously, they were fully ambulatory and showed normal interest in their surroundings. Death in 13 cases occurred by the second week postvagotomy and was associated with lung congestion or consolidation, and in two cases the liver had a nutmeg appearance.

Glomerular Filtration Rate After Alpha-Radioimmunotherapy with 211At-MX35-F(ab′)2: A Long-Term Study of Renal Function in Nude Mice

2009 ◽  
Vol 24 (6) ◽  
pp. 649-658 ◽  
Author(s):  
Tom Bäck ◽  
Börje Haraldsson ◽  
Ragnar Hultborn ◽  
Holger Jensen ◽  
Martin E. Johansson ◽  
...  
Keyword(s):  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Nude Mice ◽  
Filtration Rate ◽  
Term Study ◽  
Long Term Study

Effects of captopril treatment versus placebo on renal function in type 2 diabetic patients with microalbuminuria: a long-term study

1994 ◽  
Vol 72 (12) ◽  
pp. 961-966 ◽  
Author(s):  
M. Capek ◽  
C. Schnack ◽  
B. Ludvik ◽  
A. Kautzky-Willer ◽  
M. Banyai ◽  
...  
Keyword(s):  
Renal Function ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Term Study ◽  
Long Term Study ◽  
Type 2 Diabetic ◽  
Captopril Treatment

scholarly journals The Nature of Herpes Zoster: A Long-Term Study and a New Hypothesis

1965 ◽  
Vol 58 (1) ◽  
pp. 9-20 ◽  
Author(s):  
R Edgar Hope-Simpson
Keyword(s):  
Herpes Zoster ◽  
Primary Infection ◽  
Sensory Ganglia ◽  
Varicella Infection ◽  
Term Study ◽  
Long Term Study ◽  
High Incidence ◽  
Low Prevalence ◽  
New Hypothesis

Dr Hope-Simpson presents a study of all cases of herpes zoster occurring in his general practice during a sixteen-year period. The rate was 3·4 per thousand per annum, rising with age, and the distribution of lesions reflected that of the varicella rash. It was found that severity increased with age, but that the condition did not occur in epidemics, and that there was no characteristic seasonal variation. A low prevalence of varicella was usually associated with a high incidence of zoster. Dr Hope-Simpson suggests that herpes zoster is a spontaneous manifestation of varicella infection. Following the primary infection (chickenpox), virus becomes latent in the sensory ganglia, where it can be reactivated from time to time (herpes zoster). Herpes zoster then represents an adaptation enabling varicella virus to survive for long periods, even without a continuous supply of persons susceptible to chickenpox.

FP683THE PRESERVATION OF RESIDUAL RENAL FUNCTION WITH HIGH DOSE OF FUROSEMIDE. A PILOT LONG TERM STUDY

2019 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Romina Alcuaz ◽  
Eduardo Nozzi ◽  
Nora Vivas ◽  
Guillermo Diaz ◽  
David Aiziczon ◽  
...  
Keyword(s):  
Renal Function ◽  
Residual Renal Function ◽  
High Dose ◽  
Term Study ◽  
Long Term Study
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