Increased incidence of solid malignant tumors after bone marrow transplantation for severe aplastic anemia [see comments]
Keyword(s):
Abstract From May 1980 to December 1989, 107 consecutive patients with non- constitutional severe aplastic anemia underwent bone marrow transplantation at our institution using cyclophosphamide and thoraco- abdominal irradiation as conditioning regimen. During the same period, 40 patients with Fanconi anemia were also grafted after a similar conditioning, giving a total series of 147 patients. With a mean follow- up of 64 months, four male patients developed a solid malignant tumor, a number that leads to an 8-year cumulative incidence rate of 22% (eg, relative risk to general population = 41, P less than .001). These results should be considered as a warning to clinicians who follow these successfully grafted long-term patients.
2001 ◽
Vol 28
(5)
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pp. 523-526
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1990 ◽
pp. 96-103
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1996 ◽
Vol 14
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pp. 165-172
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1999 ◽
Vol 24
(3)
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pp. 253-257
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