Diagnostic yield of transbronchial lung cryobiopsy for diffuse parenchymal lung diseases diagnosis: 1.7 mm and 1.9 mm probe

2021 ◽  
Author(s):  
Fabio Sultani ◽  
Claudia Ravaglia ◽  
Silvia Puglisi ◽  
Sara Piciucchi ◽  
Alessandra Dubini ◽  
...  
Keyword(s):  
Lung Diseases ◽  
Diagnostic Yield ◽  
Diffuse Parenchymal Lung Diseases ◽  
Transbronchial Lung Cryobiopsy ◽  
Parenchymal Lung

scholarly journals Diagnostic approach in parenchymal lung diseases: transbronchial lung biopsy or cryobiopsy?

2020 ◽  
Vol 50 (6) ◽  
pp. 1535-1539
Author(s):  
Ali Kadri ÇIRAK ◽  
Nuran KATGI ◽  
Onur Fevzi ERER ◽  
Pınar ÇİMEN ◽  
Fatma Fevziye TUKSAVUL ◽  
...  
Keyword(s):  
Lung Biopsy ◽  
Lung Diseases ◽  
Interstitial Lung Diseases ◽  
Massive Hemorrhage ◽  
Open Lung Biopsy ◽  
Transbronchial Lung Biopsy ◽  
Diffuse Parenchymal Lung Diseases ◽  
Training And Research ◽  
Transbronchial Lung Cryobiopsy ◽  
Parenchymal Lung

Background/aim: Diagnosis of interstitial lung diseases requires a multidisciplinary approach, and a gold standard for histological diagnosis is open lung biopsy. Transbronchial lung biopsy (TBLB) and in recent years an alternative method, cryobiopsy (TBLC), are used for the diagnosis of parenchymal lung lesions. The aim of this study is to compare the efficacy of concomitant conventional TBLB and TBLC.Materials and methods: A total of 82 patients who underwent TBLC for diagnosis of diffuse parenchymal lung diseases at Dr. Suat Seren Chest Diseases and Surgery Training and Research Hospital between 2015 and 2018 were screened retrospectively and included in the study. Of the patients, 53.7% (n: 44) were male, and 46.4% (n:38) of them were female. The mean age was 58.37 (±9.33) years. First TBLB and then TBLC were performed to all patients in the same session and their diagnostic performances were compared.Results: Although both procedures were done in the same session, 45 patients (54.9%) were diagnosed with TBLB and 75 patients (91.5%) were diagnosed with TBLC (P ˂ 0.001). Hemorrhage was observed in 39 patients (47.6%), but only one had a massive hemorrhage. Pneumothorax was observed in 6 patients (7.3%) and none of them required tube drainage.Conclusion: Transbronchial lung cryobiopsy is a promising technique for the diagnosis of parenchymal lung diseases compared to transbronchial lung biopsy.

scholarly journals Ultrasonography for the Diagnosis of Pneumothorax after Transbronchial Lung Cryobiopsy in Diffuse Parenchymal Lung Diseases

Respiration ◽  
2017 ◽  
Vol 94 (2) ◽  
pp. 232-236 ◽  
Author(s):  
Luca Viglietta ◽  
Riccardo Inchingolo ◽  
Cristina Pavano ◽  
Sara Tomassetti ◽  
Sara Piciucchi ◽  
...  
Keyword(s):  
Lung Diseases ◽  
Diffuse Parenchymal Lung Diseases ◽  
Transbronchial Lung Cryobiopsy ◽  
Parenchymal Lung

scholarly journals Role of Transbronchial Lung Cryobiopsies in Diffuse Parenchymal Lung Diseases: Interest of a Sequential Approach

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Benjamin Bondue ◽  
Thierry Pieters ◽  
Patrick Alexander ◽  
Paul De Vuyst ◽  
Maria Ruiz Patino ◽  
...  
Keyword(s):  
Lung Diseases ◽  
Diagnostic Yield ◽  
Safety Data ◽  
Pathological Diagnosis ◽  
Surgical Biopsy ◽  
Sequential Approach ◽  
Related Condition ◽  
Additional Information ◽  
Diffuse Parenchymal Lung Diseases ◽  
Parenchymal Lung

Background. Transbronchial lung cryobiopsies (TBLCs) are a promising diagnostic tool in the setting of diffuse parenchymal lung diseases (DPLDs). However, no comparison with surgical lung biopsy (SLB) in the same patient is available. Methods. The diagnostic yield and safety data of TBLCs, as well as the result of SLB performed after TBLCs, were analysed in a multicentric Belgian study. A SLB was performed after TBLCs in absence of a definite pathological diagnosis or if a NSIP pattern was observed without related condition identified following multidisciplinary discussion. Results. Between April 2015 and November 2016, 30 patients were included. Frequent complications included pneumothorax (20%) and bleeding (severe 7%, moderate 33%, and mild 53%). There was no mortality. The overall diagnostic yield was 80%. A SLB was performed in six patients (three without definite histological pattern and three with an NSIP). The surgical biopsy changed the pathological diagnosis into a UIP pattern in five patients and confirmed a NSIP pattern in one patient. Conclusion. TBLCs are useful in the diagnostic work-up of DPLDs avoiding a SLB in 80% of the patients. However, surgical biopsies, performed as a second step after TBLCs because of an indefinite diagnosis or a NSIP pattern, provide additional information supporting the interest of a sequential approach in these patients.

scholarly journals Lung Cryobiopsy Outside of the Operating Room: A Safe Alternative to Surgical Biopsy

2021 ◽  
pp. 155698452110345
Author(s):  
Vanessa Menezes ◽  
Juan Carlos Molina ◽  
Clare Pollock ◽  
Philippe Romeo ◽  
Julie Morisset ◽  
...  
Keyword(s):  
Operating Room ◽  
Lung Diseases ◽  
Diagnostic Yield ◽  
Interstitial Lung Diseases ◽  
Minor Bleeding ◽  
Hypoxemic Respiratory Failure ◽  
Surgical Biopsy ◽  
Histologic Diagnosis ◽  
Safe Alternative ◽  
Diffuse Parenchymal Lung Diseases

Objective Transbronchial lung cryobiopsy (TBLC) is a promising technique that can provide a histologic diagnosis in interstitial lung diseases (ILD) and is an alternative to surgical lung biopsy. The main concerns with the procedure are safety and diagnostic accuracy. The technique is applicable in patients unable to undergo surgical biopsy due to severe comorbidities or when patient transport to the operating room is dangerous. This study reports the initial experience with TBLC on a thoracic surgical service as a first attempt at diagnosis in patients with diffuse parenchymal lung diseases (DPLD). Methods Between May 2018 and July 2020, 32 patients underwent TBLC using bedside flexible bronchoscopy for suspected ILD on a thoracic surgical endoscopy service. Retrospective evaluation of the procedure details, complications, and diagnostic yield were analyzed and reported. Results A total of 89 pathological samples were obtained (mean 2.8 per patient). Pneumothorax and minor bleeding occurred in 25% and 16.7% of patients, respectively. Sixty-seven percent of complications occurred with use of the 2.4 mm cryoprobe ( P = 0.036). Concordance between the histologic diagnosis and final clinical diagnosis was observed in 62.5% of patients and the pathology guided the final treatment in 71% ( P = 0.027) with Kappa-concordance of 0.60 ( P < 0.001). Conclusions Cryobiopsy is becoming part of the diagnostic evaluation in patients with indeterminate DPLD or hypoxemic respiratory failure. TBLC is easy to perform and has a favorable safety profile. Thoracic specialists should consider adding TBLC to their procedural armamentarium as a first option for patients with indeterminate PLD.

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