Short term model of COPD acute exacerbation combining cigarette smoke inhalation and Influenza A virus infection in mice.

2019 ◽  
Author(s):  
Maximiliano Ruben Ferrero ◽  
Cristiana Couto Garcia ◽  
Julian Torres ◽  
Tatiana Paula Ferreira ◽  
Ana Carolina Arantes ◽  
...  
Keyword(s):  
Virus Infection ◽  
Acute Exacerbation ◽  
Cigarette Smoke ◽  
Influenza A Virus ◽  
Influenza A ◽  
Smoke Inhalation ◽  
Short Term ◽  
Term Model ◽  
Influenza A Virus Infection

scholarly journals Influenza A virus infection and cigarette smoke impair bronchodilator responsiveness to β-adrenoceptor agonists in mouse lung

2016 ◽  
Vol 130 (10) ◽  
pp. 829-837 ◽  
Author(s):  
Chantal Donovan ◽  
Huei Jiunn Seow ◽  
Jane E. Bourke ◽  
Ross Vlahos
Keyword(s):  
Virus Infection ◽  
Lung Disease ◽  
Cigarette Smoke ◽  
Influenza A Virus ◽  
Influenza A ◽  
Mouse Lung ◽  
Adrenoceptor Agonists ◽  
Influenza A Virus Infection ◽  
Bronchodilator Responsiveness

The present study has shown that the bronchodilator effectiveness of β-adrenoceptor agonists is diminished in CS and influenza A virus-induced lung disease and has identified the need for the development of novel bronchodilators for these diseases.

scholarly journals RIG-I overexpression decreases mortality of cigarette smoke exposed mice during influenza A virus infection

2017 ◽  
Vol 18 (1) ◽  
Author(s):  
Xiaoqiu Wang ◽  
Wenxin Wu ◽  
Wei Zhang ◽  
J. Leland Booth ◽  
Elizabeth S. Duggan ◽  
...  
Keyword(s):  
Virus Infection ◽  
Cigarette Smoke ◽  
Influenza A Virus ◽  
Influenza A ◽  
Influenza A Virus Infection

scholarly journals Induction of cyclophilin A by influenza A virus infection facilitates group A Streptococcus coinfection

Cell Reports ◽  
2021 ◽  
Vol 35 (7) ◽  
pp. 109159
Author(s):  
Xiaoyuan Bai ◽  
Wenxian Yang ◽  
Xiaohan Luan ◽  
Huizi Li ◽  
Heqiao Li ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Group A Streptococcus ◽  
Cyclophilin A ◽  
Group A ◽  
Influenza A Virus Infection

scholarly journals Dicer is involved in protection against influenza A virus infection

2007 ◽  
Vol 88 (10) ◽  
pp. 2627-2635 ◽  
Author(s):  
Alexey A. Matskevich ◽  
Karin Moelling
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Mammalian Cells ◽  
Influenza A ◽  
Virus Production ◽  
Vero Cells ◽  
Antiviral Response ◽  
Protein Levels ◽  
Infected Cells ◽  
Influenza A Virus Infection

In mammals the interferon (IFN) system is a central innate antiviral defence mechanism, while the involvement of RNA interference (RNAi) in antiviral response against RNA viruses is uncertain. Here, we tested whether RNAi is involved in the antiviral response in mammalian cells. To investigate the role of RNAi in influenza A virus-infected cells in the absence of IFN, we used Vero cells that lack IFN-α and IFN-β genes. Our results demonstrate that knockdown of a key RNAi component, Dicer, led to a modest increase of virus production and accelerated apoptosis of influenza A virus-infected cells. These effects were much weaker in the presence of IFN. The results also show that in both Vero cells and the IFN-producing alveolar epithelial A549 cell line influenza A virus targets Dicer at mRNA and protein levels. Thus, RNAi is involved in antiviral response, and Dicer is important for protection against influenza A virus infection.

scholarly journals A Functional Variation in CD55 Increases the Severity of 2009 Pandemic H1N1 Influenza A Virus Infection

2012 ◽  
Vol 206 (4) ◽  
pp. 495-503 ◽  
Author(s):  
Jie Zhou ◽  
Kelvin Kai-Wang To ◽  
Hui Dong ◽  
Zhong-Shan Cheng ◽  
Candy Choi-Yi Lau ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
H1n1 Influenza ◽  
Pandemic H1n1 ◽  
Functional Variation ◽  
Pandemic H1n1 Influenza ◽  
Influenza A Virus Infection
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