Non-monophyly and intricate morphological evolution within the avian family Cettiidae revealed by multilocus analysis of a taxonomically densely sampled dataset

Two new morphological measurements based on digital image analysis, CoContinuity and CoContinuity Balance, have been developed and implemented for quantitative measurement of morphology in polymer blends. The morphology of polymer blends varies with phase ratio, composition and processing. A typical morphological evolution for increasing phase ratio of polymer A to polymer B starts with discrete domains of A in a matrix of B (A/B < 1), moves through a cocontinuous distribution of A and B (A/B ≈ 1) and finishes with discrete domains of B in a matrix of A (A/B > 1). For low phase ratios, A is often seen as solid convex particles embedded in the continuous B phase. As the ratio increases, A domains begin to evolve into irregular shapes, though still recognizable as separate domains. Further increase in the phase ratio leads to A domains which extend into and surround the B phase while the B phase simultaneously extends into and surrounds the A phase.

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Multilocus Analysis of Genetic Susceptibility to Myocardial Infarction in Russians: Replication Study

Acta Naturae ◽

10.32607/20758251-2017-9-4-74-83 ◽

2017 ◽

Vol 9 (4) ◽

pp. 74-83

Author(s):

N. G. Kukava ◽

B. V. Titov ◽

G. J. Osmak ◽

N. A. Matveeva ◽

O. G. Kulakova ◽

...

Keyword(s):

Myocardial Infarction ◽

Genetic Markers ◽

Prognostic Significance ◽

Cumulative Effect ◽

Mthfr Gene ◽

Composite Model ◽

Replication Study ◽

Epistatic Interactions ◽

Multilocus Analysis ◽

Lipid Metabolism Genes

In search of genetic markers of myocardial infarction (MI) risk, which have prognostic significance for Russians, we performed a replication study of MI association with genetic variants of PCSK9 (rs562556), APOE (epsilon polymorphism, rs7412 and rs429358), LPL (rs320), MTHFR (rs1801133), eNOS (rs2070744), and the 9p21 region (rs1333049) in 405 patients with MI and 198 controls. Significant MI association was observed with variants of the lipid metabolism genes (PCSK9, APOE and LPL), and of eNOS. The SNPs in the MTHFR gene and the 9p21 region were not significantly associated with MI one by one but were included in several different MI-associated allelic combinations identified by multilocus analysis. Since we have not revealed nonlinear epistatic interactions between the components of the identified combinations, we postulate that the cumulative effect of genes that form a combination arises from the summation of their small independent contributions. The prognostic significance of the additive composite model built from the PCSK9, APOE, LPL, and eNOS genes as genetic markers was assessed using ROC analysis. After we included these markers in the previously published composite model of individual genetic risk of MI, the prognostic efficacy in our sample reached AUC = 0.676. However, the results obtained in this study certainly need to be replicated in an independent sample of Russians.

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Multilocus Analysis of Genetic Susceptibility to Myocardial Infarction in Russians: Replication Study

Acta Naturae ◽

10.32607/2075851-2017-9-74-83 ◽

2017 ◽

Vol 9 (4) ◽

pp. 74-83

Author(s):

N. G. Kukava ◽

◽

B. V. Titov ◽

G. J. Osmak ◽

N. A. Matveeva ◽

...

Keyword(s):

Myocardial Infarction ◽

Genetic Susceptibility ◽

Replication Study ◽

Multilocus Analysis

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Towards a comprehensive view of weevil morphological evolution: Prospects and progress from the 1K Weevils project

10.1603/ice.2016.93190 ◽

2016 ◽

Author(s):

Dave J Clarke

Keyword(s):

Morphological Evolution ◽

Comprehensive View

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Operando Visualization of Morphological Dynamics in All-Solid-State Batteries

10.26434/chemrxiv.8299406 ◽

2019 ◽

Author(s):

Xiaohan Wu ◽

Juliette Billaud ◽

Iwan Jerjen ◽

Federica Marone ◽

Yuya Ishihara ◽

...

Keyword(s):

Solid State ◽

Solid Electrolytes ◽

Rational Design ◽

Morphological Evolution ◽

Active Material ◽

Composite Layer ◽

Transference Number ◽

Thermal Stabilities ◽

Solid State Batteries ◽

All Solid State Batteries

<div> <div> <div> <p>All-solid-state batteries are considered as attractive options for next-generation energy storage owing to the favourable properties (unit transference number and thermal stabilities) of solid electrolytes. However, there are also serious concerns about mechanical deformation of solid electrolytes leading to the degradation of the battery performance. Therefore, understanding the mechanism underlying the electro-mechanical properties in SSBs are essentially important. Here, we show three-dimensional and time-resolved measurements of an all-solid-state cell using synchrotron radiation x-ray tomographic microscopy. We could clearly observe the gradient of the electrochemical reaction and the morphological evolution in the composite layer. Volume expansion/compression of the active material (Sn) was strongly oriented along the thickness of the electrode. While this results in significant deformation (cracking) in the solid electrolyte region, we also find organized cracking patterns depending on the particle size and their arrangements. This study based on operando visualization therefore opens the door towards rational design of particles and electrode morphology for all-solid-state batteries. </p> </div> </div> </div>

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