scholarly journals Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children

2008 ◽  
Vol 7 (1) ◽  
Author(s):  
Elizabeth A Ashley ◽  
Loretxu Pinoges ◽  
Eleanor Turyakira ◽  
Grant Dorsey ◽  
Francesco Checchi ◽  
...  
Keyword(s):  
Falciparum Malaria ◽  
Uncomplicated Falciparum Malaria ◽  
In Vivo Efficacy ◽  
African Children ◽  
Methodological Approaches

scholarly journals Treatment of African Children with Uncomplicated Falciparum Malaria with a New Antimalarial Drug, CGP 56697

1997 ◽  
Vol 176 (4) ◽  
pp. 1113-1116 ◽  
Author(s):  
Lorenz von Seidlein ◽  
Shabbar Jaffar ◽  
Margaret Pinder ◽  
Michelle Haywood ◽  
Georges Snounou ◽  
...  
Keyword(s):  
Falciparum Malaria ◽  
Antimalarial Drug ◽  
Uncomplicated Falciparum Malaria ◽  
African Children

scholarly journals Glycocalyx breakdown is increased in African children with cerebral and uncomplicated falciparum malaria

2019 ◽  
Vol 33 (12) ◽  
pp. 14185-14193 ◽  
Author(s):  
Tsin W. Yeo ◽  
Peggy A. Bush ◽  
Youwei Chen ◽  
Sarah P. Young ◽  
Haoyue Zhang ◽  
...  
Keyword(s):  
Falciparum Malaria ◽  
Uncomplicated Falciparum Malaria ◽  
African Children

scholarly journals Efficacy of sulfadoxine/pyrimethamine for uncomplicated Plasmodium falciparum malaria in a small sample of Sudanese children

2004 ◽  
Vol 10 (3) ◽  
pp. 309-314
Author(s):  
I. Adam ◽  
M. H. Ibrahim ◽  
I. A. Aelbasit ◽  
M. I. El Bashir
Keyword(s):  
Plasmodium Falciparum ◽  
Falciparum Malaria ◽  
Plasmodium Falciparum Malaria ◽  
Small Sample ◽  
In Vivo Efficacy ◽  
Late Treatment ◽  
High Level ◽  
Uncomplicated Plasmodium Falciparum Malaria

A prospective clinical trial was carried out to determine in vivo efficacy of sulfadoxine/pyrimethamine for the treatment of uncomplicated Plasmodium falciparum malaria in children in New Halfa. Forty patients were enrolled; 31 completed the 28-day follow-up. Six [19.4%] patients showed recurrence of parasitaemia during follow-up, while the rest [80.6%] cleared the parasites and responded fully to treatment. All the failures were late treatment failures. Parasite genotyping showed that 1 [16.7%] of the 6 cases of late parasitaemia was due to reinfection while the rest [83.4%] were due to true recrudescence. During the follow-up period 22.6% of patients showed gametocytaemia. The high level of treatment failure as well as gametocytaemia necessitates the introduction of artesunate in this combination therapy

scholarly journals Efficacy and Tolerability of Malartin and Sulphadoxine-Pyrimethamine Combination against Uncomplicated Falciparum Malaria in Dibanda, Southwest Cameroon

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Helen Kuokuo Kimbi ◽  
Mesame Ntoko ◽  
Nelson N. Ntonifor ◽  
Emmaculate Lum ◽  
Anna L. Njunda ◽  
...  
Keyword(s):  
Falciparum Malaria ◽  
Drug Combination ◽  
Age Groups ◽  
Social Classes ◽  
Uncomplicated Falciparum Malaria ◽  
Artemisinin Derivatives ◽  
The Difference ◽  
Sulphadoxine Pyrimethamine

Artemisinin derivatives are now the most potent and rapidly acting antimalarials. The aim of this study was to assess thein vivoefficacy and tolerability of a combination of Malartin (an artesunate) and sulphadoxine-pyrimethamine (SP) in the treatment of uncomplicated falciparum malaria in Dibanda, Cameroon. A total of 197 subjects were recruited into the study and administered Malartin for 3 days and SP as a single dose on day 0. Only 174 of the subjects were successfully followed up on days 3, 7, and 14. The overall success rate of the drug combination was 92.53%. Parasite density decreased during the follow-up period in different age groups, sexes, and social classes. The prevalence of anaemia decreased from 22.99% at enrolment to 9.77% on day 14, and the difference was significant (P<0.05) on all days of followup. The drug combination did not give rise to any serious side effects.

scholarly journals In Vivo Efficacy of Mefloquine for the Treatment of Falciparum Malaria in Brazil

1999 ◽  
Vol 180 (6) ◽  
pp. 2077-2080 ◽  
Author(s):  
Crispim Cerutti, Jr. ◽  
Rui Rafael Durlacher ◽  
Filomena E. C. de Alencar ◽  
Aluísio A. C. Segurado ◽  
Lorrin W. Pang
Keyword(s):  
Falciparum Malaria ◽  
In Vivo Efficacy
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