scholarly journals A common polymorphic allele of the LH beta-subunit gene is associated with higher exogenous FSH consumption during controlled ovarian stimulation for assisted reproductive technology

2013 ◽  
Vol 11 (1) ◽  
pp. 51 ◽  
Author(s):  
Carlo Alviggi ◽  
Kim Pettersson ◽  
Salvatore Longobardi ◽  
Claus Andersen ◽  
Alessandro Conforti ◽  
...  
2017 ◽  
Vol 2017 ◽  
pp. 1-14 ◽  
Author(s):  
Baiju Ahemmed ◽  
Vani Sundarapandian ◽  
Rohit Gutgutia ◽  
Sathya Balasubramanyam ◽  
Richa Jagtap ◽  
...  

Purpose.To improve success of in vitro fertilization (IVF), assisted reproductive technology (ART) experts addressed four questions. What is optimum oocytes number leading to highest live birth rate (LBR)? Are cohort size and embryo quality correlated? Does gonadotropin type affect oocyte yield? Should “freeze-all” policy be adopted in cycles with progesterone >1.5 ng/mL on day of human chorionic gonadotropin (hCG) administration?Methods.Electronic database search included ten studies on which panel gave opinions for improving current practice in controlled ovarian stimulation for ART.Results.Strong association existed between retrieved oocytes number (RON) and LBRs. RON impacted likelihood of ovarian hyperstimulation syndrome (OHSS). Embryo euploidy decreased with age, not with cohort size. Progesterone > 1.5 ng/dL did not impair cycle outcomes in patients with high cohorts and showed disparate results on day of hCG administration.Conclusions.Ovarian stimulation should be designed to retrieve 10–15 oocytes/treatment. Accurate dosage, gonadotropin type, should be selected as per prediction markers of ovarian response. Gonadotropin-releasing hormone (GnRH) antagonist based protocols are advised to avoid OHSS. Cumulative pregnancy rate was most relevant pregnancy endpoint in ART. Cycles with serum progesterone ≥1.5 ng/dL on day of hCG administration should not adopt “freeze-all” policy. Further research is needed due to lack of data availability on progesterone threshold or index.


Author(s):  
Cátia Manuela Ribeiro Barbosa Martins ◽  
Patrícia C P de F G C Ruivo ◽  
Denise Cristina Mós Vaz-Oliani ◽  
Renato Alessandre Silva Martins ◽  
Antonio Helio Oliani

Drugs ◽  
2020 ◽  
Vol 80 (10) ◽  
pp. 973-994
Author(s):  
Annalisa Racca ◽  
Panagiotis Drakopoulos ◽  
Ana Raquel Neves ◽  
Nikolaos P. Polyzos

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