scholarly journals Identification and Characterization of Seven New Exon 11-Associated Splice Variants of the Rat Mu Opioid Receptor Gene, OPRM1

2011 ◽  
Vol 7 ◽  
pp. 1744-8069-7-9 ◽  
Author(s):  
Jin Xu ◽  
Mingming Xu ◽  
Grace C Rossi ◽  
Gavril W Pasternak ◽  
Ying-Xian Pan
2009 ◽  
Vol 108 (4) ◽  
pp. 962-972 ◽  
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Jin Xu ◽  
Mingming Xu ◽  
Yasmin L. Hurd ◽  
Gavril W. Pasternak ◽  
Ying-Xian Pan

Pain ◽  
2014 ◽  
Vol 155 (10) ◽  
pp. 2063-2070 ◽  
Author(s):  
Jeffrey S. Wieskopf ◽  
Ying-Xian Pan ◽  
Jaclyn Marcovitz ◽  
Alexander H. Tuttle ◽  
Susruta Majumdar ◽  
...  

2003 ◽  
Vol 301 (4) ◽  
pp. 1057-1061 ◽  
Author(s):  
Ying-Xian Pan ◽  
Jin Xu ◽  
Loriann Mahurter ◽  
Mingming Xu ◽  
Annie-Kim Gilbert ◽  
...  

Author(s):  
Arjun Muralidharan ◽  
Alexander Samoshkin ◽  
Marino Convertino ◽  
Marjo Hannele Piltonen ◽  
Pavel Gris ◽  
...  

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Steven Grinnell ◽  
Susruta Majumdar ◽  
Michael Ansonoff ◽  
John Pintar ◽  
Ying‐Xian Pan ◽  
...  

Biomolecules ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1525
Author(s):  
Shan Liu ◽  
Wen-Jia Kang ◽  
Anna Abrimian ◽  
Jin Xu ◽  
Luca Cartegni ◽  
...  

Most opioid analgesics used clinically, including morphine and fentanyl, as well as the recreational drug heroin, act primarily through the mu opioid receptor, a class A Rhodopsin-like G protein-coupled receptor (GPCR). The single-copy mu opioid receptor gene, OPRM1, undergoes extensive alternative splicing, creating multiple splice variants or isoforms via a variety of alternative splicing events. These OPRM1 splice variants can be categorized into three major types based on the receptor structure: (1) full-length 7 transmembrane (TM) C-terminal variants; (2) truncated 6TM; and (3) single TM variants. Increasing evidence suggests that these OPRM1 splice variants are pharmacologically important in mediating the distinct actions of various mu opioids. More importantly, the OPRM1 variants can be targeted for development of novel opioid analgesics that are potent against multiple types of pain, but devoid of many side-effects associated with traditional opiates. In this review, we provide an overview of OPRM1 alternative splicing and its functional relevance in opioid pharmacology.


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