scholarly journals Super-resolution fluorescence imaging of intracellular mutant huntingtin protein reveals a population of fibrillar aggregates co-existing with compact perinuclear inclusion bodies

2013 ◽  
Vol 8 (Suppl 1) ◽  
pp. O18
Author(s):  
Steffen J Sahl ◽  
Lucien E Weiss ◽  
Lana Lau ◽  
Judith Frydman ◽  
WE Moerner
Keyword(s):  
Fluorescence Imaging ◽  
Inclusion Bodies ◽  
Super Resolution ◽  
Mutant Huntingtin ◽  
Huntingtin Protein ◽  
Mutant Huntingtin Protein

scholarly journals The Aggregation-Prone Mutant Huntingtin Protein in a Cellular Context - Approaches by Super-Resolution Imaging

2014 ◽  
Vol 106 (2) ◽  
pp. 683a ◽  
Author(s):  
Steffen J. Sahl ◽  
Willianne I.M. Vonk ◽  
Lucien E. Weiss ◽  
Lana Lau ◽  
Judith Frydman ◽  
...  
Keyword(s):  
Super Resolution ◽  
Mutant Huntingtin ◽  
Huntingtin Protein ◽  
Mutant Huntingtin Protein ◽  
Cellular Context ◽  
Resolution Imaging

D01 Two independent validations of a mutant huntingtin protein (MHTT) assay to support the clinical development of mHTT-targeting therapies in HD

2021 ◽  
Author(s):  
David Hawellek ◽  
Stephanie Vauleon ◽  
Katharina Schutz ◽  
Benoit Massonnet ◽  
Nanda Gruben ◽  
...  
Keyword(s):  
Clinical Development ◽  
Mutant Huntingtin ◽  
Huntingtin Protein ◽  
Mutant Huntingtin Protein

scholarly journals The pathobiology of perturbed mutant huntingtin protein–protein interactions in Huntington's disease

2019 ◽  
Vol 151 (4) ◽  
pp. 507-519 ◽  
Author(s):  
Erich E. Wanker ◽  
Anne Ast ◽  
Franziska Schindler ◽  
Philipp Trepte ◽  
Sigrid Schnoegl
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Protein Interactions ◽  
Mutant Huntingtin ◽  
Protein Protein Interactions ◽  
Huntingtin Protein ◽  
Mutant Huntingtin Protein

Distinct aggregation and cell death patterns among different types of primary neurons induced by mutant huntingtin protein

2004 ◽  
Vol 89 (4) ◽  
pp. 974-987 ◽  
Author(s):  
Kazuhiko Tagawa ◽  
Masataka Hoshino ◽  
Tomohiro Okuda ◽  
Hiroko Ueda ◽  
Hiroshi Hayashi ◽  
...  
Keyword(s):  
Cell Death ◽  
Primary Neurons ◽  
Mutant Huntingtin ◽  
Huntingtin Protein ◽  
Different Types ◽  
Mutant Huntingtin Protein

Effect of Pesticides on the Aggregation of Mutant Huntingtin Protein

2012 ◽  
Vol 45 (3) ◽  
pp. 405-414 ◽  
Author(s):  
Ruhi S. Deshmukh ◽  
Rajeev K. Chaudhary ◽  
Ipsita Roy
Keyword(s):  
Mutant Huntingtin ◽  
Huntingtin Protein ◽  
Mutant Huntingtin Protein

Histone deacetylase activity is retained in primary neurons expressing mutant huntingtin protein

2003 ◽  
Vol 87 (1) ◽  
pp. 257-267 ◽  
Author(s):  
Masataka Hoshino ◽  
Kazuhiko Tagawa ◽  
Tomohiro Okuda ◽  
Miho Murata ◽  
Kiyomitsu Oyanagi ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Primary Neurons ◽  
Mutant Huntingtin ◽  
Huntingtin Protein ◽  
Mutant Huntingtin Protein
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