Local allergic rhinitis is a new rhinitis phenotype characterized by symptoms
similar to allergic rhinitis, in non-atopic patients with a positive nasal
allergen provocation test (NAPT). The disease is diagnosed in over 25% of
non-atopic patients with rhinitis, marked as non-atopic rhinitis. It most
often has perennial and severe symptoms and a progressive course. It is
often associated with conjunctivitis and/or asthma. It is necessary to
consider local allergic rhinitis in patients with non-atopic rhinitis. The
gold standard for diagnosis is positive NAPT. Pharmacological therapy fails
to stop the natural progression and development of comorbidities. Allergen
immunotherapy reduces the symptoms, consumption of medicines and increases
the tolerance to allergens responsible for local allergic rhinitis. New
studies are needed to confirm curative and evaluate the preventive effects
of allergen immunotherapy.
Clinical changes induced by allergen immunotherapy with dermatophagoides pteronyssinus in local allergic rhinitis
