scholarly journals The effect of oral contraceptive pills on the macula, the retinal nerve fiber layer, the ganglion cell layer and the choroidal thickness

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Yasmine Maher Shaaban ◽  
Tamer Abdel Fattah Badran
Keyword(s):  
Oral Contraceptive ◽  
Ganglion Cell ◽  
Nerve Fiber ◽  
Choroidal Thickness ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Control Group ◽  
Fiber Layer ◽  
Oral Contraceptive Pills ◽  
Contraceptive Pills

Abstract Backgroun To evaluate the effect of oral contraceptive pills (OCP) on the macula, the retinal nerve fiber layer (RNFL), the ganglion cell layer (GCL), and the choroidal thickness (CT). Methods In this prospective observational cross-sectional study, 60 eyes of 30 healthy women taking monophasic OCP (0.03 mg ethinylestradiol and 0.15 mg levonorgestrel) for contraception for at least 1 year were compared with 60 eyes of a control group of 30 healthy women who were not taking any OCP. Spectral-Domain Optical Coherence Tomography (SD-OCT) was used to evaluate the macula, the RNFL, the GCL, and the CT. Measurements were taken in the follicular phase (day 3) of the last menstrual cycle in all women. The body mass index (BMI) scores of all participants were also recorded. Results No disparity in terms of age and BMI between both groups was observed (p = 0.444, p = 0.074, respectively). All the macular parameters measurements were considerably lower in the OCP group compared to the control group (p < 0.001). Also, the RNFL thickness, the GCL thickness, and the CT were all significantly thinner in the OCP group (p < 0.001). Conclusions The use of OCP can cause significant changes in the retina and choroid thickness over 1 year period. The women who are using OCP for a longer duration could have some eye problems. OCT should be routinely done for follow up. Further long term studies are required, using different preparations of OCP. It is important to find out when this thickness alterations can be clinically significant or symptomatic and if these changes are reversible or not.

scholarly journals The Effect of Oral Contraceptive Pills on The Macula, the Retinal Nerve Fiber Layer, The Ganglion Cell Layer and The Choroidal Thickness

2019 ◽  
Author(s):  
Yasmine Maher Shaaban ◽  
Tamer Abdel-Fattah Badran
Keyword(s):  
Oral Contraceptive ◽  
Nerve Fiber ◽  
Choroidal Thickness ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Control Group ◽  
Fiber Layer ◽  
Oral Contraceptive Pills ◽  
Contraceptive Pills ◽  
One Year

Abstract Background To evaluate the effect of oral contraceptive pills (OCP) on the macula, the retinal nerve fiber layer (RNFL), the ganglion cell layer ( GCL), and the choroidal thickness (CT). Methods In this prospective observational cross-sectional study, 60 eyes of 30 healthy women taking mono phasic OCP (0.03 mg ethinylestradiol and 0.15 mg levonorgestrel) for contraception for at least one year were compared with 60 eyes of a control group of 30 healthy women who were not taking any OCP. Spectral-Domain Optical Coherence Tomography (SD-OCT) was used to evaluate the macula, the RNFL, the GCL, and the CT. Measurements were taken in the follicular phase (day 3) of the last menstrual cycle in all women. The body mass index (BMI) scores of all participants were also recorded. Results No disparity in terms of age and BMI between both groups was observed (p=0.444, p=0.074, respectively). All the macular parameters measurements were considerably lower in the OCP group compared to the control group (p<0.001). Also, the RNFL thickness, the GCL thickness, and the CT were all significantly thinner in the OCP group (p<0.001). Conclusions The use of OCP can cause significant changes in the retina and choroid thickness over one year period. The women who are using OCP for a longer duration could have some eye problems. OCT should be routinely done for follow up. Further long term studies are required, using different preparations of OCP. It is important to find out when this thickness alterations can be clinically significant or symptomatic and if these changes are reversible or not. Keywords Oral Contraceptive, Macula, Nerve fiber, Ganglion, Choroid, Ocular Coherence Tomography.

scholarly journals The Effect of Oral Contraceptive Pills on the Macula, the Retinal Nerve Fiber Layer, The Ganglion Cell layer and The Choroidal Thickness

2019 ◽  
Author(s):  
Yasmine Maher Shaaban ◽  
Tamer Abdel-Fattah Badran
Keyword(s):  
Oral Contraceptive ◽  
Ganglion Cell ◽  
Choroidal Thickness ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Control Group ◽  
Fiber Layer ◽  
Oral Contraceptive Pills ◽  
Contraceptive Pills ◽  
One Year

Abstract Background To evaluate the effect of oral contraceptive pills (OCP) on the macula, the retinal nerve fiber layer (RNFL), the ganglion cell layer ( GCL), and the choroidal thickness (CT). Methods In this prospective observational cross-sectional study, 60 eyes of 30 healthy women taking monophasic OCP (0.03 mg ethinylestradiol and 0.15 mg levonorgestrel) for contraception for at least one year were compared with 60 eyes of a control group of 30 healthy women who were not taking any OCP. Spectral Domain Optical Coherence Tomography (SD-OCT) was used to evaluate the macula, the RNFL, the GCL, and the CT. Measurements were taken in the follicular phase (day 3) of the last menstrual cycle in all women. Results No disparity in terms of age between both groups was observed (p=0.444). All the macular parameters measurements were considerably lower in the OCP group compared to the control group (p<0.001). Also, the RNFL thickness, the GCL thickness, and the CT were all significantly thinner in the OCP group (p<0.001). Conclusions The use of OCP can cause significant changes in the retina and choroid thickness over one year period. The women who are using OCP for longer duration could have some eye problems. OCT should be routinely done for follow up. Further long term studies are required, using different preparations of OCP. It is important to find out when this thickness alterations can be clinically significant or symptomatic and if these changes are reversible or not.

scholarly journals The Effect of Oral Contraceptive Pills on the Macula, the Retinal Nerve Fiber Layer, The Ganglion Cell layer and The Choroidal Thickness

2019 ◽  
Author(s):  
Yasmine Maher Shaaban ◽  
Tamer Abdel-Fattah Badran
Keyword(s):  
Oral Contraceptive ◽  
Nerve Fiber ◽  
Choroidal Thickness ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Control Group ◽  
Fiber Layer ◽  
Oral Contraceptive Pills ◽  
Contraceptive Pills ◽  
One Year

Abstract p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; text-align: justify; font: 10.0px 'Times New Roman'} p.p2 {margin: 0.0px 0.0px 6.0px 0.0px; text-align: justify; font: 10.0px 'Times New Roman'} p.p3 {margin: 0.0px 0.0px 12.0px 0.0px; text-align: justify; font: 10.0px 'Times New Roman'} span.s1 {letter-spacing: 0.0px} AbstractBackground To evaluate the effect of oral contraceptive pills (OCP) on the macula, the retinal nerve fiber layer (RNFL), the ganglion cell layer ( GCL), and the choroidal thickness (CT).Methods In this prospective observational cross-sectional study, 60 eyes of 30 healthy women taking monophasic OCP (0.03 mg ethinylestradiol and 0.15 mg levonorgestrel) for contraception for at least one year were compared with 60 eyes of a control group of 30 healthy women who were not taking any OCP. Spectral-Domain Optical Coherence Tomography (SD-OCT) was used to evaluate the macula, the RNFL, the GCL, and the CT. Measurements were taken in the follicular phase (day 3) of the last menstrual cycle in all women. The body mass index (BMI) scores of all participants were also recorded.Results No disparity in terms of age and BMI between both groups was observed (p=0.444, p=0.074, respectively). All the macular parameters measurements were considerably lower in the OCP group compared to the control group (p<0.001). Also, the RNFL thickness, the GCL thickness, and the CT were all significantly thinner in the OCP group (p<0.001).Conclusions The use of OCP can cause significant changes in the retina and choroid thickness over one year period. The women who are using OCP for a longer duration could have some eye problems. OCT should be routinely done for follow up. Further long term studies are required, using different preparations of OCP. It is important to find out when this thickness alterations can be clinically significant or symptomatic and if these changes are reversible or not.Keywords Oral Contraceptive, Macula, Nerve fiber, Ganglion, Choroid, Ocular Coherence Tomography.

scholarly journals The Effect of Oral Contraceptive Pills on the Macula, the Retinal Nerve Fiber Layer, and Choroidal Thickness

2017 ◽  
Vol 23 ◽  
pp. 5657-5661 ◽  
Author(s):  
Yusuf Madendag ◽  
Gokhan Acmaz ◽  
Mustafa Atas ◽  
Erdem Sahin ◽  
Ahter Tanay Tayyar ◽  
...  
Keyword(s):  
Oral Contraceptive ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Choroidal Thickness ◽  
Fiber Layer ◽  
Oral Contraceptive Pills ◽  
Nerve Fiber Layer ◽  
Contraceptive Pills ◽  
Retinal Nerve Fiber

scholarly journals Evaluation of retinal nerve fiber layer and ganglion cell layer thickness in Alzheimer's disease using optical coherence tomography

2020 ◽  
Author(s):  
Panitha Jindahra ◽  
Nitchanan Hengsiri ◽  
Pirada Witoonpanich ◽  
Anuchit Poonyathalang ◽  
Teeratorn Pulkes ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Control Group ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
The Mean

Abstract Background: To evaluate the feasibility of using optical coherence tomography (OCT) for the detection of Alzheimer's disease (AD), by measuring the thickness of the retinal nerve fiber layer (RNFL) and the ganglion cell layer and inner plexiform layer (GCL-IPL).Methods: This was a single-center, cross-sectional study. The study included 29 patients with AD (mean age ± standard deviation: 75.61 ± 6.24 years) and 29 healthy age- and sex-matched controls. All participants underwent cognitive evaluations using the Montreal Cognitive Assessment test. Measurements of the RNFL thickness, as well as GCL-IPL thickness, were obtained for all participants using OCT. Both RNFL and GCL-IPL parameters were adjusted for best–corrected visual acuity.Results: The mean RNFL thickness was significantly thinner in the AD group than in the control group (85.24 and 90.68 µm, respectively, adjusted P = 0.019). The superior quadrant was thinner in the AD group (adjusted P = 0.042). The thicknesses did not differ significantly between groups for the other quadrants. The mean GCL-IPL thickness in the AD (68.81 µm) was significantly thinner than that in the controls (76.42 µm) (adjusted P = 0.010). Overall, there was a negative correlation between age and mean RNFL; and between age and GCL-IPL thickness (r = − 0.338, P = 0.010 and r = − 0.346, P = 0.008, respectively).Conclusions: The mean RNFL and GCL-IPL thicknesses were thinner in the AD group than in the control group. These findings suggest that RNFL and GCL-IPL thickness may be biological markers for AD.

Effect of duration and severity of migraine on retinal nerve fiber layer, ganglion cell layer, and choroidal thickness

2018 ◽  
Vol 28 (6) ◽  
pp. 714-721 ◽  
Author(s):  
Mona K Abdellatif ◽  
Mohamed M Fouad
Keyword(s):  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Choroidal Thickness ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Determinant Factor ◽  
Retinal Nerve Fiber

Purpose: To investigate the factors in migraine that have the highest significance on retinal and choroidal layers’ thickness. Methods: Ninety patients with migraine and 40 age-matched healthy participants were enrolled in this observational, cross-sectional study. After full ophthalmological examination, spectral domain-optical coherence tomography was done for all patients measuring the thickness of ganglion cell layer and retinal nerve fiber layer. Enhanced depth imaging technique was used to measure the choroidal thickness. Results: There was significant thinning in the superior and inferior ganglion cell layers, all retinal nerve fiber layer quadrants, and all choroidal quadrants (except for the central subfield) in migraineurs compared to controls. The duration of migraine was significantly correlated with ganglion cell layer, retinal nerve fiber layer, and all choroidal quadrants, while the severity of migraine was significantly correlated with ganglion cell layer and retinal nerve fiber layer only. Multiregression analysis showed that the duration of migraine is the most important determinant factor of the superior retinal nerve fiber layer quadrant (β = −0.375, p = 0.001) and in all the choroidal quadrants (β = −0.531, −0.692, −0.503, −0.461, −0.564, respectively, p  < 0.001), while severity is the most important determinant factor of inferior, nasal, and temporal retinal nerve fiber layer quadrants (β = −0.256, −0.335, −0.308; p  = 0.036, 0.005, 0.009, respectively) and the inferior ganglion cell layer hemisphere (β = −0.377 and p = 0.001). Conclusion: Ganglion cell layer, retinal nerve fiber layer, and choroidal thickness are significantly thinner in patients with migraine. The severity of migraine has more significant influence in the thinning of ganglion cell layer and retinal nerve fiber layer, while the duration of the disease affected the choroidal thickness more.

Evaluation of Retinal Neurodegeneration and Choroidal Thickness in Patients with Inactive Gravesʼ Ophthalmopathy

2021 ◽  
Author(s):  
Muhammed M. Kurt ◽  
Cetin Akpolat ◽  
Ferhat Evliyaoglu ◽  
Merve Yilmaz ◽  
Fikriye Ordulu
Keyword(s):  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Choroidal Thickness ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
And Control ◽  
Retinal Nerve Fiber

Abstract Purpose The study was conducted for the assessment of the retinal nerve fiber layer, ganglion cell layer, and subfoveal choroidal thickness changes in patients with inactive Gravesʼ ophthalmopathy (GO) using swept-source optical coherence tomography (SS-OCT) before the development of active GO findings. Materials and Methods The cross-sectional designed study consisted of patients with inactive Gravesʼ ophthalmopathy (study group) and healthy subjects (control group). The thicknesses of the retinal ganglion cell layer, retinal nerve fiber layer, and subfoveal choroid (SFCT) were measured using SS-OCT with deep range imaging technology to compare these parameters between the study and control groups. Result Patients with inactive Gravesʼ ophthalmopathy had higher values of intraocular pressure but similar best-corrected visual acuity (p = 0.001, p = 0.232, respectively). The retinal nerve fiber layer was thinner only in the superior zone of the study group (p = 0.039), whereas similar values were noted in the temporal, nasal, and inferior areas as well as the average thickness. We did not observe any statistically significant difference in any sector of the ganglion cell layer between the study and control groups. A thicker mean subfoveal choroidal thickness value was measured in patients with inactive Gravesʼ ophthalmopathy than in healthy subjects (p = 0.013) in correlation with a clinical activity score (p = 0.046). Conclusion SS-OCT showed minimal retinal neurodegenerative alteration and significant choroidal thickening in inactive GO. Thus, SS-OCT might be a beneficial technique to detect retinal neurodegenerative and choroidal changes earlier in the stage of inactive GO before the development of active GO signs, which may affect the time and type of treatment modalities to prevent further ocular or systemic complications. Additionally, SFCT may be a good indicator for assessment of the severity of Gravesʼ disease.

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