scholarly journals Intestinal and vascular smooth muscle relaxant effect of Viscum album explains its medicinal use in hyperactive gut disorders and hypertension

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Taous Khan ◽  
Sayyad Ali ◽  
Rahila Qayyum ◽  
Izhar Hussain ◽  
Fazli Wahid ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Relaxant ◽  
Viscum Album ◽  
Relaxant Effect ◽  
Medicinal Use ◽  
Smooth Muscle Relaxant

Modulation of vascular tone by neutrophils: dependence on endothelial integrity

1989 ◽  
Vol 257 (4) ◽  
pp. H1315-H1320
Author(s):  
J. L. Mehta ◽  
D. L. Lawson ◽  
W. W. Nichols ◽  
P. Mehta
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Relaxant ◽  
Muscle Tone ◽  
Muscle Relaxation ◽  
Smooth Muscle Relaxation ◽  
Smooth Muscle Tone ◽  
High Concentrations ◽  
Vascular Smooth Muscle Tone ◽  
Smooth Muscle Relaxant

To determine the influence of polymorphonuclear leukocytes (PMNLs) on vascular smooth muscle tone, isolated human PMNLs (10(4)–10(7) cells/ml) were suspended in a tissue bath with precontracted rat aortic rings with or without endothelium. PMNLs in low concentrations (10(4) and 10(5) cells/ml) caused a mild contraction, and in higher concentrations (10(6) and 10(7) cells/ml) caused a modest relaxation of aortic rings with intact endothelium. In contrast, PMNLs caused a potent concentration-dependent relaxation of deendothelialized rings (P less than 0.01 compared with rings with intact endothelium). The PMNL-induced vascular smooth muscle relaxation was abolished by both hemoglobin and methylene blue and potentiated by both superoxide dismutase and captopril. Although suspension of PMNLs caused release of eicosanoids, thromboxane A2 and prostacyclin, from rings with intact endothelium, neither indomethacin nor the TxA2-endoperoxide receptor antagonist SQ 29548 modified the effects of PMNLs on vascular smooth muscle tone. These observations suggest that unstimulated PMNLs generate a smooth muscle relaxant, which has biological characteristics similar to the endothelium-derived relaxing factor. Since the activity of this PMNL-derived smooth muscle relaxant is more pronounced in deendothelialized vascular segments, it appears that endothelium provides a barrier against vasorelaxation by high concentrations of PMNLs.

scholarly journals Isoeugenolol: A Selective β1-Adrenergic Antagonist With Tracheal and Vascular Smooth Muscle Relaxant Properties

1999 ◽  
Vol 80 (2) ◽  
pp. 127-136 ◽  
Author(s):  
Young-Tso Lin ◽  
Bin-Nan Wu ◽  
Chiou-Fenq Horng ◽  
Yeun-Chih Huang ◽  
Show-Jen Hong ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Relaxant ◽  
Adrenergic Antagonist ◽  
Smooth Muscle Relaxant

scholarly journals Human Meconium Has a Pulmonary Vascular and Airway Smooth Muscle Relaxant Effect

2008 ◽  
Vol 64 (1) ◽  
pp. 24-28 ◽  
Author(s):  
Rogerio Tessler ◽  
Jingyi Pan ◽  
Humberto Holmer Fiori ◽  
Jaques Belik
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Muscle Relaxant ◽  
Relaxant Effect ◽  
Smooth Muscle Relaxant
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