Comparison of the efficacy of intranasal ketamine versus intravenous ketorolac on acute non-traumatic headaches: a randomized double-blind clinical trial

Abstract Introduction Non - traumatic headaches are one of the most common causes of referral to hospital emergency. This study aimed to compare the efficacy of intranasal ketamine and intravenous ketorolac on acute non-traumatic headaches. Methods This randomized and double-blind clinical trial was conducted in 2019. One hundred and forty samples were randomly divided into intranasal ketamine (A) and intravenous ketorolac (B). Group (A) received ketamine intranasal (0.75 mg/kg, max 75 mg), and group B received intravenous ketorolac (30 mg). Headache severity was measured on arrival, 30, 60, and 120 min after intervention with Visual Analogue Scale (VAS). The side effects were recorded an hour after the intervention. Result The mean difference of pain intensity 30, 60, and 120 min after the intervention between the two groups was statistically significant (p < 0.001). In the first 30 min, significant changes were observed in the VAS levels of the two groups. These changes were significantly greater in the intranasal ketamine group (p < 0.001). Side effects such as fatigue, dizziness, general discomfort, nausea, increased heart rate, and hypertension were significantly higher in the ketamine group (p < 0.05). Conclusion Intranasal ketamine and intravenous ketorolac both effectively reduced headaches. However, more analgesic effects of intranasal ketamine in a short time can be considered as a selective approach to reducing headaches. Trial registration IRCT20180108038276N3, Registered 29 September 2019. Ethics committee reference number IR.KUMS.REC.1398.068.

Download Full-text

Comparison the Efficacy of Intranasal Ketamine Versus Intravenous Ketorolac on Acute Non-Traumatic Headaches: A Randomized Double-Blind Clinical Trial

10.21203/rs.3.rs-99460/v1 ◽

2020 ◽

Author(s):

Houman Rafiee Sarvari ◽

Hamidreza Baigrezaii ◽

Mohammad Nazarianpirdosti ◽

Amirhossein Meysami ◽

Roya Safari-Faramani

Keyword(s):

Clinical Trial ◽

Side Effects ◽

Double Blind ◽

Analgesic Effects ◽

Headache Severity ◽

Selective Approach ◽

Double Blind Clinical Trial ◽

Group B ◽

Short Time ◽

Intravenous Ketorolac

Abstract Introduction: Non - traumatic headaches are one of the most common causes of referral to hospital emergency. This study aimed to compare the efficacy of intranasal ketamine and intravenous ketorolac on acute non-traumatic headaches.Methods: This randomized and double-blind clinical trial in 2019 years. 140 people were randomly divided into intranasal ketamine (A) and intravenous ketorolac (B). Group (A) received ketamine intranasal (0.75 mg/kg, max 75mg), and group B received intravenous ketorolac (30 mg). Headache severity was measured on arrival, 30, 60, and 120 minutes after intervention with Visual Analogue Scale (VAS). The side effects were recorded an hour after the intervention.Result: The mean difference of pain intensity 30, 60, and 120 minutes after the intervention between the two groups were statistically significant (p<0.001). In the first 30 minutes, significant changes were observed in the VAS levels of the two groups. These changes were more and significant in the intranasal ketamine group (p <0.001). Side effects such as fatigue, dizziness, public discomfort, nausea, increased heart rate, and hypertension were significantly higher in the ketamine group (p <0.05).Conclusion: Intranasal ketamine and intravenous ketorolac both effectively reduced headaches. However, more analgesic effects of intranasal ketamine in a short time can be considered as a selective approach to reducing headaches.

Download Full-text

Comparison the Efficacy of Intranasal Ketamine Versus Intravenous Ketorolac on Acute Non-traumatic Headaches: A Randomized Double-Blind Clinical Trial

10.21203/rs.3.rs-97688/v1 ◽

2020 ◽

Author(s):

Houman Rafiee Sarvari ◽

Hamidreza Baigrezaii ◽

Mohammad Nazarianpirdosti ◽

Amirhossein Meysami ◽

Roya Safari-Faramani

Keyword(s):

Clinical Trial ◽

Side Effects ◽

Double Blind ◽

Analgesic Effects ◽

Headache Severity ◽

Selective Approach ◽

Double Blind Clinical Trial ◽

Group B ◽

Short Time ◽

Intravenous Ketorolac

Download Full-text

Double-blind clinical trial of the analgesic effects of phenazocine hydrobromide (Narphen) compared with morphine sulphate in patients with acute abdominal pain

Gut ◽

10.1136/gut.12.1.51 ◽

1971 ◽

Vol 12 (1) ◽

pp. 51-54 ◽

Cited By ~ 3

Author(s):

D. Hopton

Keyword(s):

Clinical Trial ◽

Abdominal Pain ◽

Acute Abdominal Pain ◽

Morphine Sulphate ◽

Double Blind ◽

Analgesic Effects ◽

Double Blind Clinical Trial

Download Full-text

Comparison of the Analgesic Effects of Dexketoprofen and Diclofenac During Shockwave Lithotripsy: A Randomized, Double-Blind Clinical Trial

Journal of Endourology ◽

10.1089/end.2009.0257 ◽

2010 ◽

Vol 24 (6) ◽

pp. 1031-1035 ◽

Cited By ~ 7

Author(s):

Husnu Tokgoz ◽

Serhan Yurtlu ◽

Volkan Hanci ◽

Ozlem Turksoy ◽

Bulent Erol ◽

...

Keyword(s):

Clinical Trial ◽

Shockwave Lithotripsy ◽

Double Blind ◽

Analgesic Effects ◽

Double Blind Clinical Trial

Download Full-text

Comparison of Preemptive Analgesic Effects of Intravenous Ketorolac and Oral Pregabalin in Patients Undergoing Mandibular Fracture Surgery: A Randomized Clinical Trial

Avicenna Journal of Dental Research ◽

10.34172/ajdr.2020.11 ◽

2020 ◽

Vol 12 (2) ◽

pp. 51-57

Author(s):

Javad Yazdani ◽

Saeed Nezafati ◽

Ali Mortazavi ◽

Farrokh Farhadi ◽

Milad Ghanizadeh

Keyword(s):

Clinical Trial ◽

Postoperative Pain ◽

Postoperative Period ◽

Opioid Analgesic ◽

Mandibular Fractures ◽

Analgesic Effects ◽

Group A ◽

The Mean ◽

Group B ◽

Intravenous Ketorolac

Background: Preemptive analgesia is one of the techniques to manage postoperative pain, which increases patient satisfaction and decreases the duration of hospitalization. The present study aimed to evaluate and compare the pain relief achieved by preoperative intravenous ketorolac and oral pregabalin in patients undergoing surgery for mandibular fractures. Methods: In the present clinical trial, 60 patients with unilateral fractures of the mandible were randomly assigned to two groups. In group A, intravenous injections of ketorolac 30 mg and in group B, pregabalin 150 mg capsules were administrated one hour preoperatively. The severity of pain was determined using a visual analog scale (VAS) up to 24 hours postoperatively. Finally, the total doses of an opioid analgesic (pethidine) prescribed for each patient in mg during the first 24 hours and the time for the request of the first analgesic dose in minutes were recorded for each patient. Then, their means were compared between the two groups. Results: Maximum pain severity was experienced immediately after surgery, which decreased gradually during the 24-hour postoperative period (P < 0.0001). The mean severity of pain immediately after regaining consciousness and the mean pain score during the 24-hour postoperative period were lower in the pregabalin group than in the ketorolac group (P < 0.0001). In the ketorolac group, a slightly higher dose of the opioid was administered; however, the difference was not significant (P > 0.05). Conclusions: The oral administration of pregabalin 150 mg one hour preoperatively was more effective than the intravenous administration of ketorolac 30 mg in relieving postoperative pain.

Download Full-text

Comparative study of double blind clinical trial in side-effects among Areca catechu l., Thai traditional herbal formula and mebendazole

Tropical Parasitology ◽

10.4103/2229-5070.105176 ◽

2012 ◽

Vol 2 (2) ◽

pp. 116 ◽

Cited By ~ 3

Author(s):

Buavaroon Srichaikul ◽

Jaruwan Viroj ◽

Gordon Bakker ◽

Supachai Samappito

Keyword(s):

Clinical Trial ◽

Side Effects ◽

Comparative Study ◽

Herbal Formula ◽

Double Blind ◽

Double Blind Clinical Trial ◽

Areca Catechu

Download Full-text

A Long Term Double-Blind Clinical Trial of Ibuprofen and Indomethacin in Rheumatoid Arthritis

Journal of International Medical Research ◽

10.1177/030006057500300304 ◽

1975 ◽

Vol 3 (3) ◽

pp. 158-171 ◽

Cited By ~ 9

Author(s):

G L Royer ◽

T E Moxley ◽

M S Hearron ◽

A Miyara ◽

B M Shenker

Keyword(s):

Rheumatoid Arthritis ◽

Clinical Trial ◽

Side Effects ◽

Double Blind ◽

Double Blind Clinical Trial

Two-hundred and eighteen individuals with rheumatoid arthritis were randomly assigned to six months treatment with ibuprofen (900-1800 mg/day) or indomethacin (75-150 mg/day). The drugs were equally effective in the treatment of rheumatoid arthritis while the incidence of indomethacin side-effects was 1·5 times greater than the incidence of ibuprofen side-effects.

Download Full-text

Analgesia and side effects of codeine phosphate associated with paracetamol vs. paracetamol after the extraction of mandibular third molars: a randomized double-blind clinical trial using the split-mouth model

Oral and Maxillofacial Surgery ◽

10.1007/s10006-020-00888-x ◽

2020 ◽

Author(s):

Matheus Furtado de Carvalho ◽

Yuri Slusarenko da Silva ◽

Peter Reher ◽

Maria da Graça Naclério-Homem

Keyword(s):

Clinical Trial ◽

Side Effects ◽

Codeine Phosphate ◽

Third Molars ◽

Double Blind ◽

Double Blind Clinical Trial ◽

Mandibular Third Molars

Download Full-text

Treatment of patients with Schistosomiasis mansoni: a double blind clinical trial comparing praziquantel with oxamniquine

Revista do Instituto de Medicina Tropical de São Paulo ◽

10.1590/s0036-46651986000300007 ◽

1986 ◽

Vol 28 (3) ◽

pp. 174-180 ◽

Cited By ~ 15

Author(s):

Luiz Caetano da Silva ◽

José Murilo R. Zeitune ◽

Lucia Maria F. Rosa-Eid ◽

Dirce Mary C. Lima ◽

Rita H. Antonelli ◽

...

Keyword(s):

Clinical Trial ◽

Side Effects ◽

Statistical Significance ◽

Double Blind ◽

Chemical Structures ◽

Double Blind Clinical Trial ◽

Negative Findings ◽

Rectal Biopsies ◽

Cure Rates

A double-blind clinical trial involving 120 patients with chronic schistosomiasis was carried out to compare the tolerability and efficacy of praziquantel and oxamniquine. The patients were randomly allocated into two groups. One was treated with praziquantel, 55 mg/kg of body weight CBWT), and the other one with oxamniquine, 15mg/kg bwt, administered in a single oral dose. The diagnosis and the parasitological follow-up was based on stool examinations by quantitative Kato-Katz method and on rectal biopsies. Side-effects — mainly dizziness, sleepness, abdominal distress, headache, nausea and diarrhea — were observed in 87% of the cases. Their incidence, intensity and duration were similar for both drugs but abdominal pain was significantly more frequent after praziquantel intake and severe dizziness was more commonly reported after oxamniquine. A significant increase of alanine-aminotransferase and y-glutamyltransferase was found with the latter drug and of total bilirubin with the former one. A total of 48 patients treated with praziquantel and 46 with oxamniquine completed with negative findings the required three post-treatment parasitological controls — three slides of each stool sample on the first, third and sixth month. The achieved cure rates were 79.2% and 84.8%, respectively, a difference without statistical significance. The non-cured cases showed a mean reduction in the number of eggs per gram of feces of 93.5% after praziquantel and of 84.1% after oxamniquine. This diference also was not significant. Five patients retreated with praziquantel were cured but only one out of three treated a second time with oxamniquine. These findings show that both drugs — despite their different chemical structures, pharmacological properties and mechanisms-of-action — induce similar side-effects as well as a comparable therapeutical efficacy, in agreement with the results reported from analogous investigations.

Download Full-text