Nursing Implications of Imatinib as Molecularly Targeted Therapy for Gastrointestinal Stromal Tumors

2005 ◽  
Vol 9 (2) ◽  
pp. 161-169 ◽  
Author(s):  
Jeanne M. Griffin ◽  
Myra St. Amand ◽  
George D. Demetri
Keyword(s):  
Targeted Therapy ◽  
Gastrointestinal Stromal Tumors ◽  
Stromal Tumors ◽  
Molecularly Targeted Therapy

Targeted Therapy in Gastrointestinal Stromal Tumors

2015 ◽  
pp. 163-196 ◽  
Author(s):  
Piotr Rutkowski ◽  
Joanna Przybył ◽  
Agnieszka Wozniak ◽  
Giuseppe Badalamenti
Keyword(s):  
Targeted Therapy ◽  
Gastrointestinal Stromal Tumors ◽  
Stromal Tumors

Gastrointestinal Stromal Tumors (GISTs): From Science to Targeted Therapy

2008 ◽  
Vol 23 (2) ◽  
pp. 96-110 ◽  
Author(s):  
R. Sarmiento ◽  
P. Bonginelli ◽  
F. Cacciamani ◽  
F. Salerno ◽  
G. Gasparini
Keyword(s):  
Targeted Therapy ◽  
Tyrosine Kinase ◽  
Gastrointestinal Stromal Tumors ◽  
Kinase Inhibitor ◽  
Mesenchymal Tumors ◽  
Treatment Scenario ◽  
Stromal Tumors ◽  
Imatinib Resistant ◽  
Review Reports ◽  
Molecular Patterns

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. GISTs represent a distinct category of tumors characterized by oncogenic mutations of the KIT receptor tyrosine kinase in a majority of patients. KIT is useful not only for the diagnosis but also for targeted therapy of this disease. Imatinib, a tyrosine kinase inhibitor, is widely used in advanced and metastatic GISTs. This agent revolutionized the treatment strategy of advanced disease and is being tested in the neoadjuvant and adjuvant settings with encouraging results. New therapeutic agents like sunitinib have now been approved, enriching the treatment scenario for imatinib-resistant GISTs. The present review reports on the peculiar characteristics of this disease through its biology and molecular patterns, focusing on the predictive value of KIT mutations and their correlation with clinical outcome as well as on the activity of and resistance to approved targeted drugs.

Gastrointestinal stromal tumors (GISTs): from science to targeted therapy

2008 ◽  
Vol 23 (2) ◽  
pp. 96-110 ◽  
Author(s):  
R. Sarmiento ◽  
P. Bonginelli ◽  
F. Cacciamani ◽  
F. Salerno ◽  
G. Gasparini
Keyword(s):  
Targeted Therapy ◽  
Gastrointestinal Stromal Tumors ◽  
Stromal Tumors

Prognostic Stratification of High-risk Gastrointestinal Stromal Tumors in the Era of Targeted Therapy

2008 ◽  
Vol 247 (6) ◽  
pp. 1011-1018 ◽  
Author(s):  
Cheol Keun Park ◽  
Eui Jin Lee ◽  
Minji Kim ◽  
Ho-Yeong Lim ◽  
Dong Il Choi ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
High Risk ◽  
Gastrointestinal Stromal Tumors ◽  
Stromal Tumors ◽  
Prognostic Stratification

scholarly journals Developments in Targeted Therapy of Advanced Gastrointestinal Stromal Tumors

2011 ◽  
pp. 428-448
Author(s):  
Piotr Rutkowski ◽  
Dov Lichtenberg ◽  
Malgorzata Symonides ◽  
Marcin Zdzienicki ◽  
Janusz A. Siedlecki
Keyword(s):  
Targeted Therapy ◽  
Gastrointestinal Stromal Tumors ◽  
Stromal Tumors
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