Psychiatric Manifestation of Systemic Lupus Erythematosus in Singapore a Cross-cultural Comparison

1991 ◽  
Vol 159 (4) ◽  
pp. 520-523 ◽  
Author(s):  
Lionel Chee-Chong Lim ◽  
Tock-Eng Lee ◽  
Mee-Ling Boey
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Psychiatric Morbidity ◽  
Cross Cultural ◽  
Aetiological Factor ◽  
Systemic Lupus ◽  
Cross Cultural Comparison ◽  
Cross Cultural Study ◽  
Patient’S Perception ◽  
Oriental Population

In a case-control, cross-cultural study of the psychiatric morbidity of systemic lupus erythematosus in an Oriental population, 30 patients suffering from SLE and 29 controls with rheumatoid arthritis were interviewed. The SLE patients in Singapore exhibited greater psychiatric morbidity than their Western counterparts. Significant correlation was observed between psychiatric morbidity and the clinical disease activity. The patient's perception of the severity of arthritis, myalgia and dermatological lesions was an important aetiological factor. Culturally determined, disease-related psychological stresses also contributed to the psychopathology.

scholarly journals Cross-cultural adaptation of the Systemic Lupus Erythematosus Quality of Life Questionnaire into Chinese

2007 ◽  
Vol 57 (6) ◽  
pp. 980-985 ◽  
Author(s):  
Kok ooi Kong ◽  
Hsu Juang Ho ◽  
Hwee Siew Howe ◽  
Bernard Yu Hor Thong ◽  
Tsui Yee Lian ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Cultural Adaptation ◽  
Cross Cultural ◽  
Life Questionnaire ◽  
Systemic Lupus ◽  
Cross Cultural Adaptation ◽  
Quality Of Life Questionnaire

Disparities in Psychiatric Diagnosis and Treatment for Youth with Systemic Lupus Erythematosus: Analysis of a National US Medicaid Sample

2016 ◽  
Vol 43 (7) ◽  
pp. 1427-1433 ◽  
Author(s):  
Andrea M. Knight ◽  
Ming Xie ◽  
David S. Mandell
Keyword(s):  
Systemic Lupus Erythematosus ◽  
African Americans ◽  
Lupus Erythematosus ◽  
Acute Stress ◽  
Psychiatric Morbidity ◽  
Ethnic Disparities ◽  
Diagnosis And Treatment ◽  
Psychiatric Diagnoses ◽  
Systemic Lupus ◽  
Racial Ethnic

Objective.To estimate the national prevalence and racial/ethnic differences in psychiatric diagnoses and pharmacologic treatment in a US Medicaid beneficiary population of youth with systemic lupus erythematosus (SLE).Methods.We included youth aged 10 to 18 years with a diagnosis of SLE (defined as ≥ 3 outpatient visit claims with an International Classification of Diseases, 9th ed. code of 710.0, each > 30 days apart) in the US Medicaid Analytic Extract database from 2006 and 2007. This database contains all inpatient and outpatient Medicaid claims from 49 states and the District of Columbia. We calculated the prevalence of psychiatric diagnoses and treatment, and used logistic regression to compare depression and anxiety diagnoses, antidepressant, and anxiolytic use among racial/ethnic groups.Results.Of 970 youth with SLE, 15% were white, 42% were African American, 27% were Latino, and 16% were of other races/ethnicities. Diagnoses of depression were present for 19%, anxiety for 7%, acute stress/adjustment for 6%, and other psychiatric disorders for 18%. Twenty percent were prescribed antidepressants, 7% were prescribed anxiolytics, 6% were prescribed antipsychotics, and 5% were prescribed stimulants. In adjusted analyses, African Americans were less likely than whites to be diagnosed with depression (OR 0.56, 95% CI 0.34–0.90) or anxiety (OR 0.49, 95% CI 0.25–0.98), or to be prescribed anxiolytics (OR 0.23, 95% CI 0.11–0.48).Conclusion.We present population-level estimates showing high psychiatric morbidity in youth with SLE, but less prevalent diagnosis and treatment in African Americans. Mental health interventions should address potential racial/ethnic disparities in care.

scholarly journals Psychiatric symptoms in patients with systemic lupus erythematosus: frequency and association with disease activity using the Adult Psychiatric Morbidity Questionnaire

2013 ◽  
Vol 53 (4) ◽  
pp. 328-334
Author(s):  
Sônia Maria da Rosa Beltrão ◽  
Luciana Beltrão Gigante ◽  
Débora Beltrão Zimmer ◽  
Paulo Roberto Zimmermann ◽  
Deonilson Schmoeller ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Psychiatric Symptoms ◽  
Psychiatric Morbidity ◽  
Systemic Lupus

Organized Intraglomerular Deposits in NZB Mouse Disease

1971 ◽  
Vol 29 ◽  
pp. 544-545
Author(s):  
Francis R. Comerford ◽  
Alan S. Cohen
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antinuclear Antibodies ◽  
Human Systemic Lupus Erythematosus ◽  
Systemic Lupus ◽  
Glomerular Lesion ◽  
Ultrastructural Studies ◽  
Dense Deposits ◽  
Experimental Nephritis ◽  
Glomerular Lesions

Mice of the inbred NZB strain develop a spontaneous disease characterized by autoimmune hemolytic anemia, positive lupus erythematosus cell tests and antinuclear antibodies and nephritis. This disease is analogous to human systemic lupus erythematosus. In ultrastructural studies of the glomerular lesion in NZB mice, intraglomerular dense deposits in mesangial, subepithelial and subendothelial locations were described. In common with the findings in many examples of human and experimental nephritis, including many cases of human lupus nephritis, these deposits were amorphous or slightly granular in appearance with no definable substructure.We have recently observed structured deposits in the glomeruli of NZB mice. They were uncommon and were found in older animals with severe glomerular lesions by morphologic criteria. They were seen most commonly as extracellular elements in subendothelial and mesangial regions. The deposits ranged up to 3 microns in greatest dimension and were often adjacent to deposits of lipid-like round particles of 30 to 250 millimicrons in diameter and with amorphous dense deposits.

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