scholarly journals Affective modulation of anterior cingulate cortex in young people at increased familial risk of depression

2008 ◽  
Vol 192 (5) ◽  
pp. 356-361 ◽  
Author(s):  
Zola N. Mannie ◽  
Ray Norbury ◽  
Susannah E. Murphy ◽  
Becky Inkster ◽  
Catherine J. Harmer ◽  
...  
Keyword(s):  
Young People ◽  
Anterior Cingulate Cortex ◽  
Stroop Task ◽  
Familial Risk ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Impaired Performance ◽  
Emotional Stroop Task ◽  
Cognitive Information ◽  
History Of

BackgroundWe previously found that children of parents with depression showed impaired performance on a task of emotional categorisation.AimsTo test the hypothesis that children of parents with depression would show abnormal neural responses in the anterior cingulate cortex, a brain region involved in the integration of emotional and cognitive information.MethodEighteen young people (mean age 19.8 years) with no personal history of depression but with a biological parent with a history of major depression (FH+ participants) and 16 controls (mean age 19.9 years) underwent functional magnetic resonance imaging while completing an emotional counting Stroop task.ResultsControls showed significant activation in the pregenual anterior cingulate cortex to both positive and negative words during the emotional Stroop task. This activation was absent in FH+ participants.ConclusionsOur findings show that people at increased familial risk of depression demonstrate impaired modulation of the anterior cingulate cortex in response to emotionally valenced stimuli.

The Time Course of Activity within the Dorsal and Rostral-Ventral Anterior Cingulate Cortex in the Emotional Stroop Task

2016 ◽  
Vol 30 (1) ◽  
pp. 30-45 ◽  
Author(s):  
Farah Shahnaz Feroz ◽  
Gregor Leicht ◽  
Saskia Steinmann ◽  
Christina Andreou ◽  
Christoph Mulert
Keyword(s):  
Anterior Cingulate Cortex ◽  
Stroop Task ◽  
Time Course ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Emotional Stroop ◽  
Emotional Stroop Task

Increased myoinositol in the anterior cingulate cortex of veterans with a history of traumatic brain injury: a proton magnetic resonance spectroscopy study

2020 ◽  
Vol 123 (5) ◽  
pp. 1619-1629
Author(s):  
Chandni Sheth ◽  
Andrew P. Prescot ◽  
Margaret Legarreta ◽  
Perry F. Renshaw ◽  
Erin McGlade ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Anterior Cingulate Cortex ◽  
State Of The Art ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Resonance Spectroscopy ◽  
Spectroscopy Study ◽  
Magnetic Resonance Spectroscopy Study ◽  
History Of

In this study of veterans, we used a state-of-the-art neuroimaging tool to probe the neurometabolic profile of the anterior cingulate cortex in veterans with traumatic brain injury (TBI). We report significantly elevated myoinositol levels in veterans with TBI compared with those without TBI.

Increased Anterior Cingulate Cortex Volume in Bipolar I Disorder

2007 ◽  
Vol 41 (11) ◽  
pp. 910-916 ◽  
Author(s):  
Ali Javadapour ◽  
Gin S. Malhi ◽  
Belinda Ivanovski ◽  
Xiaohua Chen ◽  
Wei Wen ◽  
...  
Keyword(s):  
Anterior Cingulate Cortex ◽  
Matched Control ◽  
Functional Neuroimaging ◽  
Lithium Treatment ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Control Subjects ◽  
History Of ◽  
Bipolar Patients ◽  
Objective Functional

Objective: Functional neuroimaging studies have implicated the anterior cingulate cortex (ACC) in the pathophysiology of bipolar disorder (BD), but findings from volumetric studies have been less consistent, therefore the purpose of the present study was to further investigate the existence of volumetric abnormalities in the ACC cortex of individuals with BD. In addition to methodological inconsistencies many previous studies have been lacking robustness clinically with respect to characterizing bipolar patients and comparison subjects. Hence, the present study matched the groups closely across a number of demographic parameters. Methods: Using magnetic resonance imaging, ACC volumes of 24 bipolar patients were compared to 24 gender-, age-, and education-matched control subjects, and these findings were further investigated in relation to both illness and treatment factors. Results: A significantly larger (26%) right ACC in bipolar patients than control subjects was seen, and this difference was not associated with a history of psychosis, familiality, or lithium treatment, after controlling for potential confounds. Patients reporting fewer affective episodes did, however, have significantly larger ACC volumes than controls, suggesting ACC volumetric changes early in the course of BD. Conclusions: An increase in the size of the ACC may have important implications for the neurobiology of BD. It is suggested that attempts to control affective instability during the early stages of the illness necessitates greater ACC mediation via its role in conflict resolution and hence this is reflected in the increased size of the ACC early in the course of the illness.

The role of the anterior cingulate cortex in the counting Stroop task

2004 ◽  
Vol 154 (3) ◽  
pp. 355-358 ◽  
Author(s):  
Gail Hayward ◽  
Guy M. Goodwin ◽  
Catherine J. Harmer
Keyword(s):  
Anterior Cingulate Cortex ◽  
Stroop Task ◽  
Cingulate Cortex ◽  
Anterior Cingulate

scholarly journals Increased glutamate levels observed upon functional activation in the anterior cingulate cortex using the Stroop Task and functional spectroscopy

Neuroreport ◽  
2015 ◽  
Vol 26 (3) ◽  
pp. 107-112 ◽  
Author(s):  
Reggie Taylor ◽  
Betsy Schaefer ◽  
Maria Densmore ◽  
Richard W.J. Neufeld ◽  
Nagalingam Rajakumar ◽  
...  
Keyword(s):  
Anterior Cingulate Cortex ◽  
Stroop Task ◽  
Cingulate Cortex ◽  
Anterior Cingulate

scholarly journals Fatty acid dysregulation in the anterior cingulate cortex of depressed suicides with a history of child abuse

2021 ◽  
Author(s):  
Kelly Perlman ◽  
Raphael Chouinard-Watkins ◽  
Arnaud Tanti ◽  
Giulia Cisbani ◽  
Massimiliano Orri ◽  
...  
Keyword(s):  
Child Abuse ◽  
White Matter ◽  
Anterior Cingulate Cortex ◽  
Methyl Esters ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Sequencing Data ◽  
Early Life Adversity ◽  
Age Related ◽  
History Of

Child abuse (CA) strongly increases the lifetime risk of suffering from major depression and predicts an unfavorable course for the illness. Severe CA has been associated with a specific dysregulation of oligodendrocyte function and thinner myelin sheaths in the human anterior cingulate cortex (ACC) white matter. Given that myelin is extremely lipid-rich, it is plausible that these findings may be accompanied by a disruption of the lipid profile that composes the myelin sheath. This is important to explore since the composition of fatty acids (FA) in myelin phospholipids can influence its stability, permeability, and compactness. Therefore, the objective of this study was to quantify and compare FA concentrations in postmortem ACC white matter in the choline glycerophospholipid pool (ChoGpl), a key myelin phospholipid pool, between adult depressed suicides with a history of CA (DS-CA) matched depressed suicides without CA (DS) and healthy non-psychiatric controls (CTRL). Total lipids were extracted according to the Folch method and separated into respective classes using thin-layer chromatography. FA methyl esters from the ChoGpl fraction were quantified using gas chromatography. Our analysis revealed a strong age-related decrease in most FAs, and specific effects of CA in FAs from the arachidonic acid synthesis pathway, which was further validated with RNA-sequencing data. Furthermore, the concentration of most FAs was found to decrease with age. By extending the previous molecular level findings linking CA with altered myelination in the ACC, these results provide further insights regarding white matter alterations associated with early-life adversity.

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