The ADEBAR-trial: Effect of participation in a randomized phase III study (evaluating the role of adjuvant docetaxel in high-risk breast cancer patients) on treatment strategies and individual patient care in recruiting centers

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 587-587 ◽  
Author(s):  
H. Sommer ◽  
W. J. Janni ◽  
B. Rack ◽  
D. Steinfeld ◽  
W. Simon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Treatment Strategies ◽  
Phase Iii ◽  
Breast Cancer Patients ◽  
Trial Effect ◽  
Phase Iii Study ◽  
High Risk Breast Cancer ◽  
High Risk Breast ◽  
Risk Breast Cancer

scholarly journals Bisphosphonates and metastasis

2005 ◽  
Vol 8 (1) ◽  
Author(s):  
J. Lester ◽  
R. Coleman
Keyword(s):  
Breast Cancer ◽  
Bone Metastasis ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Control Pain ◽  
High Risk Breast Cancer ◽  
High Risk Breast ◽  
Risk Breast Cancer ◽  
Bone Physiology

Bone metastases frequently occur in advanced breast cancer patients and once incorporated into bone have profound effects on bone physiology. Bisphosphonates are potent inhibitors of osteoclastic function and are becoming increasingly important for the management of patients with breast cancer. They affect the ability of cancer cells to accelerate bone turnover and as a result control pain and reduce the risk of pathological fracture.Furthermore ongoing clinical trials are investigating the role of bisphosphonates as an adjuvant therapy in high-risk breast cancer patients with an aim to prevent bone metastasis.This article reviews the mechanisms of bone metastasis and will discuss present and future developments for the monitoring and treatment of metastatic bone disease.

Role of P53 and BCL-2 in high-risk breast cancer patients treated with adjuvant anthracycline-based chemotherapy

2000 ◽  
Vol 126 (12) ◽  
pp. 722-729 ◽  
Author(s):  
Marcella Mottolese ◽  
Maria Benevolo ◽  
Girolamo Del Monte ◽  
Simonetta Buglioni ◽  
Paola Papaldo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
High Risk Breast Cancer ◽  
High Risk Breast ◽  
Risk Breast Cancer
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