Compare the diagnostic value of FLT and FDG PET/CT in assessment of regional lymph nodes in thoracic esophageal squamous cell carcinoma

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e15620-e15620
Author(s):  
D. HanJ. Yu ◽  
X. Zhong ◽  
D. Mu ◽  
Z. Fu ◽  
B. Zhang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Lymph Nodes ◽  
Esophageal Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Fdg Pet ◽  
Flt Pet ◽  
Pet Ct ◽  
Fdg Pet Ct

e15620 Background: To determine whether FLT PET/CT can detect regional lymph nodes metastases in untreated thoracic esophageal squamous cell carcinoma. In view of the reported high sensitivity of FDG PET/CT for the evaluation of thoracic nodules of esophageal carcinoma, we additionally performed FDG PET/CT for direct comparison with that of FLT. Methods: From March 2008 to December 2008, 18 patients with thoracic esophageal squamous cell carcinoma underwent dual-tracer PET/CT examinations before surgery. The results of reviewing side-by-side FDG PET/CT and FLT PET/CT images for the diagnosis of locoregional lymph node metastases were compared prospectively in relation to pathologic findings. The PET images were visually inspected with the maximum standardized uptake value (SUVmax) determined from a circular region of interest (ROI) over the entire lesion. The differential threshold for malignancy was set as SUVFDG≥2.5, and SUVFLT≥1.4, respectively. Results: All patients underwent esophagectomy and lymphadenectomy, and pathologic examination confirmed nodes positive for metastasis in 14 patients and 42 of 344 excised nodes. The uptake of FDG (median SUVmax, 5.59; range, 2.5–10.6) in locoregional lymph nodes metastasis was significantly higher than that of FLT (median SUVmax, 2.93; range, 1.6–4.6). There were 14 false positive nodes in FDG PET and only 3 in FLT PET, 7 false negative nodes in FDG PET, while 11 false negative nodes in FLT PET. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of FLT PET/CT were 73.81%, 99.01%, 95.93%, 91.18% and 96.45%, respectively, whereas those of FDG PET/CT were 83.33%, 95.36%, 93.90%, 71.43% and 95.36%, respectively. P values were 0.425, 0.014, 0.298, 0.055, and 0.541, respectively. Conclusions: FLT uptake in regional lymph node of esophageal carcinoma is significantly lower compared with FDG uptake.FLT PET has fewer false-positive findings compared with FDG PET. The specificity of FLT PET/CT is higher than that of FDG. We suggest that esophageal carcinoma N-staging need to combine FLT with FDG PET/CT images. No significant financial relationships to disclose.

Quantification of Malignant Lymph Nodes and Benign Lymph Nodes in Patients of Esophageal Squamous Cell Carcinoma With Dynamic 18F-FDG PET/CT

2020 ◽  
Author(s):  
Xiaohui Wang ◽  
Qingdong Cao ◽  
Xiaojing Wang ◽  
Ying Wang ◽  
Dan Li ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Fdg Pet ◽  
Pet Ct ◽  
Significant Difference ◽  
Fdg Pet Ct ◽  
Malignant Lymph Nodes

Abstract BackgroundMost esophageal squamous cell carcinoma (ESCC) imaging diagnoses can be performed by routine CT and ultrasound, but it is difficult to detect metastatic lymph nodes or minor lesions. Functional imaging diagnosis based on 18F-FDG PET/CT has potential advantages for detection of metastatic lymph nodes, or differentiation of benign from malignant lymph nodes, and for typing and staging of ESCC. The purpose of this study is to provide 18F-FDG PET/CT imaging for ESCC patient to quantify the difference between malignant lymph nodes (MLN) and benign lymph nodes (BLN) for ESCC. MethodsDynamic 18F-FDG PET/CT was performed in 46 patients (26 patients without MLN (N0 stage) and 20 with MLN (non-N0 stage) who were pathologically confirmed for ESCC. Visual and quantitative differences were measured in primary tumor (PT), MLN and BLN regions of interest (ROIs). Finally, 52 MLN and 133 BLN (83 from N0 stage and 50 from non-N0 stage) were included for analysis. Pharmacokinetic analysis was performed by a Patlak model using Matlab program to obtain the influx constant (Ki). Maximum standardized uptake value (SUVmax) was also determined from the static and dynamic PET/CT scans. Based on the receiver operator characteristic (ROC) curve, the sensitivity and specificity for each parameter in differentiation diagnosis were evaluated. ResultsKi and SUVmax in PT non-N0 group was slightly higher than in N0 groups (0.04 ± 0.02 vs 0.03 ± 0.03, 8.01 ± 3.90 vs 7.08 ± 5.39, respectively), but with no significant difference (p > 0.05). And Ki and SUVmax in MLN were higher than BLN with statistically significant difference (KiMLN vs KiBLN ( 0.021 ± 0.014 vs 0.006 ± 0.004, p < 0.0001); (SUVmaxMLN vs SUVmaxBLN (4.35 ± 2.27 vs 1.89 ± 0.85, p < 0.0001); The sensitivity both Ki and SUVmax were 80.77 %, the specificity for Ki was 89.47%, and SUVmax 87.22% respectively. And the diagnostic accuracy Ki (90.61%) was slightly better than SUVmax (88.16%). ConclusionsQuantitative parameters (both Ki and SUVmax) of 18F-FDG in ESCC patients are sensitive diagnostic measurements capable to identify MLNs from BLNs.

FDG PET/CT in 2 Cases of Renal Metastasis From Esophageal Squamous Cell Carcinoma

2017 ◽  
Vol 42 (11) ◽  
pp. 896-898
Author(s):  
Qian Zhao ◽  
Aisheng Dong ◽  
Bo Yang ◽  
Yang Wang ◽  
Changjing Zuo
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Fdg Pet ◽  
Renal Metastasis ◽  
Pet Ct ◽  
Fdg Pet Ct

PS02.066: ROLE OF 18F-FDG-PET/CT IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA AFTER NEOADJUVANT CHEMORADIOTHERAPY

2018 ◽  
Vol 31 (Supplement_1) ◽  
pp. 139-139
Author(s):  
Tadahiro Hirashima ◽  
Ken Sasaki ◽  
Yasuto Uchikado ◽  
Itaru Omoto ◽  
Yusaku Osako ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Fdg Pet ◽  
Neoadjuvant Chemoradiotherapy ◽  
Pathological Response ◽  
Pet Ct ◽  
Before And After ◽  
Fdg Pet Ct

Abstract Background The aim of this study was to assess the role of 18F-fluorodeoxyglucose positron-emission tomography/computed tomography (FDG-PET/CT) in predicting pathological response and survival in patients with esophageal squamous cell carcinoma (ESCC) treated with neoadjuvant chemoradiotherapy (nCRT). Methods Thirty patients with advanced ESCC received nCRT followed by surgery, and underwent FDG-PET/CT twice before and after nCRT. We compared the results of FDG-PET/CT with the pathological results and prognosis. Results Pathological response was found to correlate with the maximum standardised uptake value (SUVmax) after nCRT and the rate of decrease of SUVmax. Using univariate analysis, pN, SUVmax after nCRT and the rate of decrease of SUVmax were found to be prognostic factors. Multivariate analysis revealed that only pN was an independent prognostic factor Conclusion The prediction of pathological response and prognosis using FDG-PET/CT is not as reliable as pathological detection of lymph node metastasis, but could be a useful method contributing to treatment decisions. Neoadjuvant chemoradiotherapy (nCRT) plus surgery has been shown to improve survival rates and should be regarded as a standard of care for patients with locally advanced esophageal squamous cell carcinoma (ESCC). Appropriate evaluation of nCRT efficacy based on noninvasive parameters might help in individualizing treatments for patients with ESCC. 18F-fluorodeoxyglucose positronemission tomography/computed tomography (FDG-PET/CT) reflects tumor cell viability based on enhanced FDG uptake as a result of increased glucose metabolism. FDG-PET/CT is useful for the staging of advanced ESCC before treatment, and for evaluating the response to nCRT; however, findings from currently available studies in this regard are controversial. In the present study, we examined the role and usefulness of FDG-PET/CT in decisions regarding staging, prediction of histopathological response, and overall survival in patients with advanced ESCC treated with nCRT; this was achieved by analyzing the maximum standardized uptake value (SUVmax) before and after treatment, and the rate of decrease of SUVmax. Disclosure All authors have declared no conflicts of interest.

Utility of 18F-FDG PET/CT in identifying penile squamous cell carcinoma metastatic lymph nodes

2012 ◽  
Vol 30 (5) ◽  
pp. 723-726 ◽  
Author(s):  
Henry M. Rosevear ◽  
Hadyn Williams ◽  
Matthew Collins ◽  
Andrew J. Lightfoot ◽  
Teresa Coleman ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Fdg Pet ◽  
Metastatic Lymph Nodes ◽  
Pet Ct ◽  
18F Fdg ◽  
Penile Squamous Cell Carcinoma ◽  
Fdg Pet Ct
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