Prospective evaluation of whole-body cancer screening with multiple modalities including FDG-PET: Results from annual screening for 5 years in 1,197 healthy volunteers.

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. 1517-1517
Author(s):  
S. Nishizawa ◽  
H. Kodama ◽  
Y. Maeda ◽  
H. Okada ◽  
S. Kojima ◽  
...  
2007 ◽  
Vol 43 (12) ◽  
pp. 1842-1848 ◽  
Author(s):  
Shinsuke Kojima ◽  
Bin Zhou ◽  
Satoshi Teramukai ◽  
Akiko Hara ◽  
Noboru Kosaka ◽  
...  

2009 ◽  
Vol 27 (11) ◽  
pp. 1767-1773 ◽  
Author(s):  
Sadahiko Nishizawa ◽  
Shinsuke Kojima ◽  
Satoshi Teramukai ◽  
Masayuki Inubushi ◽  
Hironobu Kodama ◽  
...  

Purpose To prospectively evaluate the utility of whole-body cancer screening with multiple modalities including [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) in a healthy population. This report summarizes the results of the first three annual screenings. Participants and Methods A total of 1,197 healthy volunteers ≥ 35 years old were enrolled between August 2003 and July 2004 and offered annual cancer screening for 5 years with subsequent long-term follow-up. Screening modalities included were whole-body FDG-PET, chest and abdominal computed tomography (CT), brain and pelvic magnetic resonance imaging, several tumor markers, and fecal occult blood testing. Results As of the end of 2006, 22 primary cancers were pathologically confirmed. Nineteen of 22 were detected by the screening; 18 in the initial, one in the second, and none in the third. Three were diagnosed after development of symptoms. Of the 18 detected in the initial screening (six thyroid, four lung, three prostate, three breast, one endometrial, and one thymic), 12 were at stage I and 11 were PET positive. PET-negative cancers were detected by CT or the prostate-specific antigen (PSA) test. Sensitivity and specificity were 50.0% (11 of 22) and 93.2% (1,095 of 1,175), respectively, for FDG-PET alone and 81.8% (18 of 22) and 82.0% (963 of 1,175), respectively, for the combination of imaging modalities and PSA. Conclusion While FDG-PET alone is insufficient, whole-body cancer screening with selected modalities including FDG-PET has initial performance supporting possible utility by detecting a wide variety of early-stage cancers with reasonable sensitivity. However, the detection of many indolent cancers and false positives necessitate continuing study for appropriate evaluation.


2013 ◽  
Vol 38 (7) ◽  
pp. e290-e296 ◽  
Author(s):  
Andrei Iagaru ◽  
Phillip Young ◽  
Erik Mittra ◽  
David W. Dick ◽  
Robert Herfkens ◽  
...  

Medicine ◽  
2016 ◽  
Vol 95 (44) ◽  
pp. e5131 ◽  
Author(s):  
Chin Hu ◽  
Chun-Peng Liu ◽  
Jin-Shiung Cheng ◽  
Yu-Li Chiu ◽  
Hung-Pin Chan ◽  
...  

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 1022-1022 ◽  
Author(s):  
S. Kojima ◽  
M. Inubushi ◽  
F. Ozawa ◽  
H. Okada ◽  
M. Tanaka ◽  
...  

1999 ◽  
pp. 179-188
Author(s):  
S. Yasuda ◽  
M. Ide ◽  
A. Shohtsu
Keyword(s):  
Fdg Pet ◽  

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