scholarly journals Occurrence of Multiple Subsequent Neoplasms in Long-Term Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study

2011 ◽  
Vol 29 (22) ◽  
pp. 3056-3064 ◽  
Author(s):  
Gregory T. Armstrong ◽  
Wei Liu ◽  
Wendy Leisenring ◽  
Yutaka Yasui ◽  
Sue Hammond ◽  
...  
Keyword(s):  
Childhood Cancer ◽  
Cumulative Incidence ◽  
Malignant Neoplasm ◽  
Childhood Cancer Survivors ◽  
Late Morbidity ◽  
Childhood Cancer Survivor Study ◽  
Survivors Of Childhood Cancer ◽  
Long Term Survivors

Purpose Childhood cancer survivors experience an increased incidence of subsequent neoplasms (SNs). Those surviving the first SN (SN1) remain at risk to develop multiple SNs. Because SNs are a common cause of late morbidity and mortality, characterization of rates of multiple SNs is needed. Patients and Methods In a total of 14,358 5-year survivors of childhood cancer diagnosed between 1970 and 1986, analyses were carried out among 1,382 survivors with an SN1. Cumulative incidence of second subsequent neoplasm (SN2), either malignant or benign, was calculated. Results A total of 1,382 survivors (9.6%) developed SN1, of whom 386 (27.9%) developed SN2. Of those with SN2, 153 (39.6%) developed more than two SNs. Cumulative incidence of SN2 was 46.9% (95% CI, 41.6% to 52.2%) at 20 years after SN1. The cumulative incidence of SN2 among radiation-exposed survivors was 41.3% (95% CI, 37.2% to 45.4%) at 15 years compared with 25.7% (95% CI, 16.5% to 34.9%) for those not treated with radiation. Radiation-exposed survivors who developed an SN1 of nonmelanoma skin cancer (NMSC) had a cumulative incidence of subsequent malignant neoplasm (SMN; ie, malignancies excluding NMSC) of 20.3% (95% CI, 13.0% to 27.6%) at 15 years compared with only 10.7% (95% CI, 7.2% to 14.2%) for those who were exposed to radiation and whose SN1 was an invasive SMN (excluding NMSC). Conclusion Multiple SNs are common among aging survivors of childhood cancer. SN1 of NMSC identifies a population at high risk for invasive SMN. Survivors not exposed to radiation who develop multiple SNs represent a population of interest for studying genetic susceptibility to neoplasia.

Visual complications in childhood cancer survivors: A Childhood Cancer Survivor Study report

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 9006-9006
Author(s):  
K. Whelan ◽  
A. Mertens ◽  
R. Castleberry ◽  
P. Mitby ◽  
T. Kawashima ◽  
...  
Keyword(s):  
Childhood Cancer ◽  
Childhood Cancer Survivors ◽  
Dry Eyes ◽  
Craniospinal Radiation ◽  
Childhood Cancer Survivor Study ◽  
Time Periods ◽  
Total Body ◽  
Long Term Survivors ◽  
Visual Conditions

9006 Background: The Childhood Cancer Survivor Study (CCSS) is an NIH funded project (U01-CA 55727) designed to study the effects of childhood cancer treatment on long- term survivors. Previous studies have found associations between certain cancer therapies and visual complications. Methods: The CCSS is a retrospective cohort study investigating health outcomes of long-term survivors (> 5 years) diagnosed and treated between 1970 and 1986 compared to a randomly selected sibling cohort. Questionnaires were completed by 14,362 survivors of childhood cancer and 3,901 sibling controls. Analysis determined the first occurrence of 8 visual conditions in 3 time periods: during therapy, end of therapy to 5 years post diagnosis, and greater than or equal to 5 years post diagnosis. Multivariate analyses, adjusting for current age and gender, determined the relative risks (RR) and 95% confidence interval (CI) of visual conditions by treatment exposure. Results: Survivors had statistically significant increases in the RR of cataracts, glaucoma, legal blindness, double vision, retinal condition, and dry eyes, across all time periods, when compared to siblings. During the time period of 5 or more years post-diagnosis, statistically significant positive associations were present for cataracts and other head radiation, craniospinal radiation, total body radiation, and prednisone; glaucoma and craniospinal radiation; double vision and craniospinal radiation; legally blind and other head radiation and craniospinal radiation; and dry eyes and other head radiation, total body radiation, and dexamethasone. There were no statistically significant associations between treatment factors and retinal conditions. Conclusions: Childhood cancer survivors are at risk of developing visual complications and treatment related factors are important determinants of this risk. Follow-up is needed to evaluate the impact of visual conditions on quality of life. [Table: see text] No significant financial relationships to disclose.

scholarly journals Generalizability of “GWAS hits” in clinical populations: Lessons from childhood cancer survivors

2020 ◽  
Author(s):  
Cindy Im ◽  
Na Qin ◽  
Zhaoming Wang ◽  
Weiyu Qiu ◽  
Carrie R. Howell ◽  
...  
Keyword(s):  
Childhood Cancer ◽  
Childhood Cancer Survivors ◽  
Clinical Settings ◽  
Cancer Therapies ◽  
Childhood Cancer Survivor Study ◽  
Meta Analyses ◽  
Methylation Patterns ◽  
Long Term Survivors ◽  
Limited Generalizability

ABSTRACTWith mounting interest in translating GWAS hits from large meta-analyses (meta-GWAS) in diverse clinical settings, evaluating their generalizability in target populations is crucial. Here we consider long-term survivors of childhood cancers from the St. Jude Lifetime Cohort Study and show the limited generalizability of 1,376 robust SNP associations reported in the general population across 12 complex anthropometric and cardiometabolic phenotypes (N=2,231; observed-to-expected replication ratio=0.68, P=2.4×10−9). An examination of five comparable phenotypes in a second independent cohort of survivors from the Childhood Cancer Survivor Study corroborated the overall limited generalizability of meta-GWAS hits to survivors (N=4,212, observed-to-expected replication ratio=0.53, P=1.1×10−16). Meta-GWAS hits were less likely to be replicated in survivors exposed to cancer therapies associated with phenotype risk. Examination of complementary DNA methylation data in a subset of survivors revealed that treatment-related methylation patterns at genomic sites linked to meta-GWAS hits may disrupt established genetic signals in survivors.

scholarly journals Longitudinal pain and pain interference in long‐term survivors of childhood cancer: A report from the Childhood Cancer Survivor Study

Cancer ◽  
2020 ◽  
Vol 126 (12) ◽  
pp. 2915-2923 ◽  
Author(s):  
Cynthia W. Karlson ◽  
Nicole M. Alberts ◽  
Wei Liu ◽  
Tara M. Brinkman ◽  
Robert D. Annett ◽  
...  
Keyword(s):  
Childhood Cancer ◽  
Cancer Survivor ◽  
Childhood Cancer Survivor ◽  
Pain Interference ◽  
Childhood Cancer Survivor Study ◽  
Survivors Of Childhood Cancer ◽  
Long Term Survivors

scholarly journals Intestinal Obstruction in Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study

2015 ◽  
Vol 33 (26) ◽  
pp. 2893-2900 ◽  
Author(s):  
Arin L. Madenci ◽  
Stacey Fisher ◽  
Lisa R. Diller ◽  
Robert E. Goldsby ◽  
Wendy M. Leisenring ◽  
...  
Keyword(s):  
Intestinal Obstruction ◽  
Childhood Cancer ◽  
Cancer Survivor ◽  
Cancer Diagnosis ◽  
Cumulative Incidence ◽  
Childhood Cancer Survivor ◽  
Cancer Type ◽  
Childhood Cancer Survivor Study ◽  
Survivors Of Childhood Cancer

Purpose For adult survivors of childhood cancer, knowledge about the long-term risk of intestinal obstruction from surgery, chemotherapy, and radiotherapy is limited. Methods Intestinal obstruction requiring surgery (IOS) occurring 5 or more years after cancer diagnosis was evaluated in 12,316 5-year survivors in the Childhood Cancer Survivor Study (2,002 with and 10,314 without abdominopelvic tumors) and 4,023 sibling participants. Cumulative incidence of IOS was calculated with second malignant neoplasm, late recurrence, and death as competing risks. Using piecewise exponential models, we assessed the associations of clinical and demographic factors with rate of IOS. Results Late IOS was reported by 165 survivors (median age at IOS, 19 years; range, 5 to 50 years; median time from diagnosis to IOS, 13 years) and 14 siblings. The cumulative incidence of late IOS at 35 years was 5.8% (95% CI, 4.4% to 7.3%) among survivors with abdominopelvic tumors, 1.0% (95% CI, 0.7% to 1.4%) among those without abdominopelvic tumors, and 0.3% (95% CI, 0.1% to 0.5%) among siblings. Among survivors, abdominopelvic tumor (adjusted rate ratio [ARR], 3.6; 95% CI, 1.9 to 6.8; P < .001) and abdominal/pelvic radiotherapy within 5 years of cancer diagnosis (ARR, 2.4; 95% CI, 1.6 to 3.7; P < .001) increased the rate of late IOS, adjusting for diagnosis year; sex; race/ethnicity; age at diagnosis; age during follow-up (as natural cubic spline); cancer type; and chemotherapy, radiotherapy, and surgery within 5 years of cancer diagnosis. Developing late IOS increased subsequent mortality among survivors (ARR, 1.8; 95% CI, 1.1 to 2.9; P = .016), adjusting for the same factors. Conclusion The long-term risk of IOS and its association with subsequent mortality underscore the need to promote awareness of this complication among patients and providers.

scholarly journals Perceived positive impact of cancer among long-term survivors of childhood cancer: a report from the childhood cancer survivor study

2011 ◽  
Vol 21 (6) ◽  
pp. 630-639 ◽  
Author(s):  
Brad J. Zebrack ◽  
Margaret L. Stuber ◽  
Kathleen A. Meeske ◽  
Sean Phipps ◽  
Kevin R. Krull ◽  
...  
Keyword(s):  
Childhood Cancer ◽  
Cancer Survivor ◽  
Positive Impact ◽  
Childhood Cancer Survivor ◽  
Childhood Cancer Survivor Study ◽  
Survivors Of Childhood Cancer ◽  
Long Term Survivors
Sign in / Sign up

Export Citation Format

Share Document